RESUMO
A preparation of immunoglobulin G isolated from a pool of immune sera derived from rabbits with long-term syphilis was shown to possess a high degree of purity as judged by immunodiffusion and protein electrophoresis. The antitreponemal power of the preparation of immunoglobulin G and that of the immune serum pool from which it was derived were found to be equivalent in both the skin protection and the systemic protection test. The observation that neither normal serum nor a pool of serum derived from animals "immunized" with Salmonella typhi, Escherichia coli, Streptococcus pyogenes, or zymosan was protective indicates that the protective power of the immune serum studied was due to specific antibodies residing principally, if not entirely, in the immunoglobulin G fraction of the serum.
Assuntos
Soros Imunes/farmacologia , Imunização Passiva , Imunoglobulina G , Sífilis/prevenção & controle , Animais , Anticorpos Antibacterianos/administração & dosagem , Eletroforese das Proteínas Sanguíneas , Eritema/etiologia , Imunodifusão , Masculino , Coelhos , Treponema pallidum/imunologiaRESUMO
The influence of prolonged treatment with serial doses of immune serum initiated either 2 or 48 h before intracutaneous challenge with Treponema pallidum on the subsequent appearance and development of lesions was studied. Whereas treatment with large doses of immune serum initiated 48 h before treponemal challenge caused a delay of 9 to 20 days in the onset of lesions and marked suppression of lesion development. Treatment initiated 2 h before treponemal challenge failed to delay the onset of lesions and only moderately suppressed their development. Lesion development was suppressed as long as treatment was continued. The significance of the results is discussed.
Assuntos
Soros Imunes/farmacologia , Imunização Passiva , Sífilis/prevenção & controle , Animais , Masculino , Coelhos , Sífilis/imunologia , Treponema pallidum/patogenicidadeAssuntos
Tatus , Hanseníase , Infecções por Mycobacterium/veterinária , Xenarthra , Animais , Modelos Animais de Doenças , PesquisaAssuntos
Fusão Celular , Linfocinas , Macrófagos/imunologia , Fagocitose , Animais , Vacina BCG , Líquidos Corporais/imunologia , Candida albicans/imunologia , Testes Imunológicos de Citotoxicidade , Reação de Imunoaderência , Pulmão/imunologia , Alvéolos Pulmonares/citologia , Coelhos , Staphylococcus/imunologiaRESUMO
Passive transfer of humoral immunity to experimental syphilis in rabbits was accomplished with large doses of hyperimmune serum. When the serum was administered before inoculation of Treponema pallidum, the onset of chancres was delayed; when it was given early in the course of infection, a transient period of arrest and healing of the chancres was imposed.
