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In late June 2021 a heatwave of unprecedented magnitude impacted the Pacific Northwest region of Canada and the United States. Many locations broke all-time maximum temperature records by more than 5 °C, and the Canadian national temperature record was broken by 4.6 °C, with a new record temperature of 49.6 °C. Here, we provide a comprehensive summary of this event and its impacts. Upstream diabatic heating played a key role in the magnitude of this anomaly. Weather forecasts provided advanced notice of the event, while sub-seasonal forecasts showed an increased likelihood of a heat extreme with lead times of 10-20 days. The impacts of this event were catastrophic, including hundreds of attributable deaths across the Pacific Northwest, mass-mortalities of marine life, reduced crop and fruit yields, river flooding from rapid snow and glacier melt, and a substantial increase in wildfires-the latter contributing to landslides in the months following. These impacts provide examples we can learn from and a vivid depiction of how climate change can be so devastating.
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PURPOSE OF REVIEW: Stationary waves are planetary-scale longitudinal variations in the time-averaged atmospheric circulation. Here, we consider the projected response of Northern Hemisphere stationary waves to climate change in winter and summer. We discuss how the response varies across different metrics, identify robust responses, and review proposed mechanisms. RECENT FINDINGS: Climate models project shifts in the prevailing wind patterns, with corresponding impacts on regional precipitation, temperature, and extreme events. Recent work has improved our understanding of the links between stationary waves and regional climate and identified robust stationary wave responses to climate change, which include an increased zonal lengthscale in winter, a poleward shift of the wintertime circulation over the Pacific, a weakening of monsoonal circulations, and an overall weakening of stationary wave circulations, particularly their divergent component and quasi-stationary disturbances. SUMMARY: Numerous factors influence Northern Hemisphere stationary waves, and mechanistic theories exist for only a few aspects of the stationary wave response to climate change. Idealized studies have proven useful for understanding the climate responses of particular atmospheric circulation features and should be a continued focus of future research.
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Histone H3 has specific sites of post-translational modifications that serve as epigenetic signals to cellular machinery to direct various processes. Mutational mimics of these modifications (glutamine for acetylation, methionine and leucine for methylation, and glutamic acid for phosphorylation) were constructed at the relevant sites of the major histone variant, H3.2, and their effects on the conformational equilibrium of the H3/H4 tetramer at physiological ionic strength were determined when bound to or free of DNA. The deposition vehicle used for this analysis was NAP1, nucleosome assembly protein 1. Acetylation mimics in the N-terminus preferentially stabilized the left-handed conformer (DNA negatively supercoiled), and mutations within the globular region preferred the right-handed conformer (DNA positively supercoiled). The methylation mimics in the N-terminus tended to maintain characteristics similar to those of wild-type H3/H4; i.e., the conformational equilibrium maintains similar levels of both left- and right-handed conformers. Phosphorylation mimics facilitated a mixed effect, i.e., when at serines, the left-handed conformer, and at threonines, a mixture of both conformers. When double mutations were present, the conformational equilibrium was shifted dramatically, either leftward or rightward depending on the specific sites. In contrast, these mutations tended not to affect the direction and extent of supercoiling for variants H3.1 and H3.3. Variant H3.3 promoted only the left-handed conformer, and H3.1 tended to maintain both conformers. Additional experiments indicate the importance of a propagation mechanism for ensuring the formation of a particular superhelical state over an extended region of the DNA. The potential relevance of these results to the maintenance of epigenetic information on a gene is discussed.
