RESUMO
Two new sterols, columnaristerols B (1) and C (2), along with two known analogues, 5,6-epoxylitosterol (3) and litosterol (4), were obtained from the octocoral Nephthea columnaris. The structures of new sterols 1 and 2 were elucidated by using spectroscopic methods and comparing the spectroscopic data with those of known related metabolites. Sterol 3 was found to suppress superoxide anion production and elastase secretion by human neutrophils.
Assuntos
Antozoários/química , Neutrófilos/efeitos dos fármacos , Esteróis/química , Animais , Antozoários/metabolismo , Anti-Inflamatórios/química , Anti-Inflamatórios/metabolismo , Anti-Inflamatórios/farmacologia , Células Cultivadas , Humanos , Modelos Moleculares , Estrutura Molecular , Esteróis/metabolismo , Esteróis/farmacologiaRESUMO
A new marine sterol, 4a-methylergosta-22(E),24(28)-dien-3 P-ol (1), was isolated from the octocoral Nephthea columnaris. The structure of I was elucidated on the basis of spectroscopic and mass spectrometric methods.
Assuntos
Antozoários/química , Esteróis/química , Animais , Estrutura MolecularRESUMO
Columnaristerol A (1), a rare natural 19-norsterol possessing a 10ß-hydroxy group was isolated from the Formosan octocoral Nephthea columnaris, and its structure was elucidated by spectroscopic methods. Sterol 1 was found to be a cytotoxic agent that exhibited in vitro moderate cytotoxic activity against MOLT-4 and SUP-T1 human leukemia-lymphoma cell lines.