Shrinkage Volume, Compressive Strength, and Surface Roughness Y-TTRIA Stabilized Tetragonal Zirconia Polycrystal (Y-TZP) Using Binders Variation PVA:PEG as an Alternative Dental Implants Materials.

OBJECTIVE: Yttria-stabilized tetragonal zirconia polycrystal (Y-TZP) is one of the materials that can be used as an alternative material for dental implants because of its good mechanical, biocompatible, and aesthetic properties. The binder used for ceramic processing to help bond is polyvinyl alcohol (PVA), which can increase the density of the ceramic material, and polyethylene glycol (PEG), which is used as a plasticizer for PVA, so it is pretty soft when pressed. MATERIALS AND METHODS: The sample was divided into five groups for volume shrinkage and compressive strength examination consisting of K1 (PVA 100%), K2 (PEG 100%), P1 (PVA:PEG 95:5), P2 (PVA:PEG 90:10), and P3 (PVA:PEG 85:15) and four groups on the surface roughness test, namely, K (PVA:PEG 1%), P1 (PVA:PEG 2%), P2 (PVA:PEG 3%), and P3 (PVA:PEG 4%). PVA:PEG binder with various concentrations was mixed with Y-TZP. The mixture was pressed using a uniaxial pressing method and continued by sintering at 1200°C for 4 hours. STATISTICAL ANALYSIS: Least significant difference (LSD) test result showed that there was a significant difference in the compressive strength value and shrinkage volume between groups K1 and K2 and P3, and groups K2 with P1, P2, and P3. Post hoc LSD surface roughness test showed a significant difference between groups K with P2 and P3 and P1 and P3 (p < 0.05). There were no significant differences (p > 0.05) between K with P1 and P2 with P3. RESULTS: The Y-TZP group with the PVA binder mixture had the highest compressive strength, while the highest volume shrinkage was found in the PEG group. The next highest compressive strength and volume shrinkage values were found in the PVA:PEG group with a ratio of 95:5, 102.44 MPa, and 12.5%. The best PVA:PEG ratio of 95:5 is used to make surface roughness measurement samples. The best results showed that mixing Y-TZP with 4% PVA:PEG binder had the highest surface roughness compared to other PVA:PEG binders, namely 1.3450 µm. CONCLUSION: From this study, it can be concluded that the best PVA:PEG percentage ratio to produce volume shrinkage and compressive strength is 95:5. The higher the concentration of PVA:PEG (95:5) binder mixed with Y-TZP, the higher the porosity will be.

Glycemic control as the main determinant factor of serum VEGF levels in type 2 diabetes mellitus patients.

Introduction. Diabetes mellitus (DM) is a main endocrine disorder that may cause vascular complications as the disease progresses. Vascular endothelial growth factor (VEGF) has been linked to the development of micro and macrovascular diabetic complications. This study aimed to assess several factors including blood pressure, body mass index, lipid profile, kidney function, and glycemic control that may provide the rise of serum VEGF levels in type 2 DM subjects. Methods. This cross-sectional study was carried out among 65 type 2 DM subjects. Systole, diastole, mean arterial pressure (MAP), and body mass index (BMI) were measured. The levels of serum VEGF were measured by Enzyme-linked immunosorbent assay (ELISA), Hemoglobin A1c (HbA1c) levels were measured by latex agglutination inhibition test, while serum glucose, lipid profiles, urea, and creatinine levels were tested by enzymatic photometric method. Results. The levels of serum VEGF had a significant correlation with BMI (p = 0.001, r = 0.397), fasting plasma glucose (FPG) (p = 0.001, r = 0.418), HbA1c (p < 0.001, r = 0.600), systole (p = 0.001), r = 0.397), diastole (p = 0.021, r = 0.286), and MAP (p = 0.001, r = 0.001). Further multivariate linear regression analysis revealed that HbA1c logarithm (log) was the determinant factor of VEGF levels (p < 0.001, ß = 0.631, Adjusted R2 = 38.9%) Conclusion. HbA1c is the main determinant factor of serum VEGF levels among type 2 DM patients.

Date palm (Phoenix dactylifera) consumption as a nutrition source for mild anemia.

OBJECTIVE: The purpose of this review is to describe an intervention that utilizes dates as a source of nutrition for pregnant women to increase hemoglobin levels in the blood in anemia incidence. The findings in this study are related to the use of dates to increase hemoglobin levels in the blood in pregnant women. METHODS: This study uses search databases used in PubMed, Science Direct, and Google Scholar. The keywords used in the initial search for articles are dates and hemoglobin obtained as many as 189 articles. At the time of using the keywords dates, hemoglobin, anemia by obtaining 15 articles and which are used only 10 articles according to the analysis of the purpose, suitability of the topic, the method of research used, sample size, research ethics, the results of each article, as well as limitations that occur. RESULT: Anemia in pregnant women causes hemoglobin (Hb) levels to decrease in the blood; the capacity of oxygen transfer to meet the needs of vital organs in the mother and fetus is reduced. All literature reviewed shows that administration of dates increases hemoglobin levels; only one literature shows no influence of consumes date juice on hemoglobin level. The majority of the literature reviewed is mild anemia. CONCLUSION: There are effective results in the implementation of health promotion of increased hemoglobin levels in the blood in pregnant women by utilizing dates as a source of nutrition.

Preeclampsia and normotensive pregnancy with tribal differences in South Sulawesi: Comparison of serum interleukin-10 (IL-10) levels.

OBJECTIVE: This study aims to compare the average levels of IL-10 with preeclampsia and normotensive in four different tribe populations in South Sulawesi, including Makassar, Bugis, Mandar, and Toraja. METHOD: This research is a cross-sectional study conducted in March-May 2020 in several Health Centre and Hospitals in four areas, namely in the UNHAS Hospital, Jumpandang Baru Health Center, Barabaraya Health Center, Mattirobulu Health Center, Salo Health Center, Lasinrang Pinrang General Hospital, Totoli Health Center, Majene Regional General Hospital, Makale Health Center, Elim General Hospital, Lakipadada Tana Toraja Regional General Hospital. Samples in this study were 88 pregnant women with gestational age >20 weeks which were divided into two groups, namely 44 cases (preeclampsia) and 44 control groups (normotensive). The criteria for the sample in this study are single pregnancy, no systemic disease, and are native Makassar, Bugis, Mandar, and Toraja tribes. Data collected included age, education, occupation, parity, Body Mass Index (BMI), history of preeclampsia. Serum IL-10 levels were examined using the Human Interleukin 10 ELISA Kit. RESULTS: There were significant differences in IL-10 levels in preeclampsia pregnant women in the Makassar, Bugis, Mandar, and Toraja tribes (p=0.020, p<0.05). In contrast to the control group, there was no difference in IL-10 levels in normotensive pregnant women in the Makassar, Bugis, Mandar, and Toraja tribes (p=0.505, p>0.05). The Bugis, Mandar, and Toraja tribes show significant differences in IL-10 levels between preeclampsia pregnant women and normotensive pregnant women with mean rating values of pregnant women who have preeclampsia have lower IL-10 levels than normotensive pregnant women, while the Makassar tribe has valued insignificant difference in IL-10 levels between preeclampsia and normotensive (p=0.309, p>0.05). CONCLUSION: There are differences in IL-10 levels in preeclampsia pregnant women in Makassar, Bugis, Mandar, and Toraja tribes. The mean concentration of IL-10 in pregnant women with preeclampsia was significantly lower than in controls.

Date palm (Phoenix dactylifera) consumption as a nutrition source for mild anemia

Objective: The purpose of this review is to describe an intervention that utilizes dates as a source of nutrition for pregnant women to increase hemoglobin levels in the blood in anemia incidence. The findings in this study are related to the use of dates to increase hemoglobin levels in the blood in pregnant women. Methods: This study uses search databases used in PubMed, Science Direct, and Google Scholar. The keywords used in the initial search for articles are dates and hemoglobin obtained as many as 189 articles. At the time of using the keywords dates, hemoglobin, anemia by obtaining 15 articles and which are used only 10 articles according to the analysis of the purpose, suitability of the topic, the method of research used, sample size, research ethics, the results of each article, as well as limitations that occur. Result: Anemia in pregnant women causes hemoglobin (Hb) levels to decrease in the blood; the capacity of oxygen transfer to meet the needs of vital organs in the mother and fetus is reduced. All literature reviewed shows that administration of dates increases hemoglobin levels; only one literature shows no influence of consumes date juice on hemoglobin level. The majority of the literature reviewed is mild anemia. Conclusion: There are effective results in the implementation of health promotion of increased hemoglobin levels in the blood in pregnant women by utilizing dates as a source of nutrition. (AU)

Preeclampsia and normotensive pregnancy with tribal differences in South Sulawesi: Comparison of serum interleukin-10 (IL-10) levels

Objective: This study aims to compare the average levels of IL-10 with preeclampsia and normotensive in four different tribe populations in South Sulawesi, including Makassar, Bugis, Mandar, and Toraja. Method: This research is a cross-sectional study conducted in March–May 2020 in several Health Centre and Hospitals in four areas, namely in the UNHAS Hospital, Jumpandang Baru Health Center, Barabaraya Health Center, Mattirobulu Health Center, Salo Health Center, Lasinrang Pinrang General Hospital, Totoli Health Center, Majene Regional General Hospital, Makale Health Center, Elim General Hospital, Lakipadada Tana Toraja Regional General Hospital. Samples in this study were 88 pregnant women with gestational age >20 weeks which were divided into two groups, namely 44 cases (preeclampsia) and 44 control groups (normotensive). The criteria for the sample in this study are single pregnancy, no systemic disease, and are native Makassar, Bugis, Mandar, and Toraja tribes. Data collected included age, education, occupation, parity, Body Mass Index (BMI), history of preeclampsia. Serum IL-10 levels were examined using the Human Interleukin 10 ELISA Kit. Results: There were significant differences in IL-10 levels in preeclampsia pregnant women in the Makassar, Bugis, Mandar, and Toraja tribes (p = 0.020, p < 0.05). In contrast to the control group, there was no difference in IL-10 levels in normotensive pregnant women in the Makassar, Bugis, Mandar, and Toraja tribes (p = 0.505, p > 0.05). The Bugis, Mandar, and Toraja tribes show significant differences in IL-10 levels between preeclampsia pregnant women and normotensive pregnant women with mean rating values of pregnant women who have preeclampsia have lower IL-10 levels than normotensive pregnant women, while the Makassar tribe has valued insignificant difference in IL-10 levels between preeclampsia and normotensive (p = 0.309, p > 0.05). (AU)

Anthropometric features in predicting insulin resistance among non-menopausal Indonesian adult females.

INTRODUCTION: The prevalence of obesity is increasing worldwide in high, low, and middle-income countries such as Indonesia. Obesity rate is higher in females in Indonesia. Obesity has important contribution in the occurrence of insulin resistance (IR) and type 2 diabetes mellitus. Several anthropometric measurements such as waist circumference (WC), body mass index (BMI), body mass (BM), total body fat percentage (Fat%) and visceral fat (VF) are related to IR. This study aimed to investigate which of those measurements could be used as a better predictor of IR in non-menopausal Indonesian adult females. METHODS: Total of 80 non-menopausal Indonesian adult females ranging from 21 to 40 years were recruited in this study. Insulin resistance was measured by using Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) equation. Subjects with HOMA-IR index >75th percentile with cut-off 2.74 were defined as IR. Waist circumference, BMI and BM were measured, while TF and VF were measured by bioelectrical impedance analysis (BIA). RESULTS: HOMA-IR had significant correlation with WC (r = 0.563, p < 0.001), BMI (r = 0.537, p < 0.001), BM (r = 0.515, p < 0.001), VF (r = 0.515, p < 0.001), Fat% (r = 0.490, p < 0.001). The area under curve of VF (0.809), BMI (0.807), WC (0.805), and BM (0.799) are slightly larger than and Fat% (0.766). CONCLUSION: Insulin resistance had strong correlation with all anthropometric measurements, but the correlation was less significant with Fat%.

Effect of PVA-PEG Binders on Surface Roughness of Y-TZP Zirconia

@#Introduction: Y-TZP Zirconia is a ceramic used for dental implants because it has good biocompatibility and aesthetic properties, and it is affordable. Y-TZP formed from powder using uniaxial pressing with some added binder. The binders used are PVA, PEG and a combination of both. This combination reduce hardness and improve plasticity properties. Significantly increasing of the binder concentration and the surface roughness of the implant increases the porosity of the material as a place for the osseointegration process. Thus, the purpose of this study was to examine the different effect of PVA-PEG binders on the surface roughness of Y-TZP zirconia. Methods: Twelve samples were divided into three treatment groups: 100% PVA, 100% PEG and 4% PVA-PEG added to Y-TZP powder at a ratio of 95:5 (wt.%). The mixture was pressed using a uniaxial pressing machine, sintered and measured: the data was then analyzed using one-way ANOVA and Post Hoc LSD. Results: The result of the ANOVA showed that there were significant differences in the surface roughness of the Y-TZP with three different binders (P<0.05). The average surface roughness of the three binders are as follows: PVA 100% (0.8025±0.23472), PEG 100% (1.2325±0.23866), 4% of PVA-PEG (1.3450±0.27695). The LSD showed that there was significant differences between PVA 100% and PEG 100% (P<0.05), PVA 100% and 4% PVA-PEG (P<0.05). There was no significant difference between PEG 100% and 4% PVA-PEG (P>0.05). Conclusion: 4% PVA-PEG binders combination has effects on the surface roughness of Y-TZP zirconia