2,4,6-Triphenylphosphinine and 2,4,6-triphenylposphabarrelene revisited: synthesis, reactivity and coordination chemistry.

The synthesis of 2,4,6-triphenylphosphinine has been revisited and a general protocol for the preparation of such low-coordinate phosphorus compounds in good to excellent yields could be established. This allows to investigate several aspects of the chemistry of 2,4,6-triarylphosphinine, such as the reaction with in situ generated benzyne to give 2,4,6-triphenylphosphabarrelene. The corresponding 2,4,6-triphenylphosphabarrelene-selenide could be characterized crystallographically for the first time and the structural and electronic properties of this cage-compound in comparison to classical triarylphosphines could be evaluated. Moreover, [(L)W(CO)5)] complexes of both 2,4,6-triphenylphosphinine and 2,4,6-triphenylphosphabarrelene were prepared and characterized by means of X-ray crystallography. This allowed for the first time a direct structural comparison of these related phosphorus compounds, coordinated to the same metal fragment.

[Inhalation therapy of upper respiratory tract diseases in metallurgists at the Ciechocinek health resort]. / Leczenie inhalacyjne schorzen górnych dróg oddechowych u hutników w uzdrowisku Ciechocinek.

Since 1972, 265 metallurgists of the Warsaw Steel-works have been treated at the ENT Department, Research Centre in Ciechocinek, for chronic atropic catarrh of upper respiratory tract mucous membrane. The treatment involved saline inhalations, respiratory exercises at a saline pool and in the open air near chimney coolers. Pathological changes were found in the mucous membrane of the metallurgists working over 5 years at high temperature and in great dustiness, and the ailments were getting intensified with the length of employment. The treatment was effective. Analysis of the collected material demonstrates that the treatment should be started already during the first 5 years of metallurgist's work. It should be meant as prophylaxis of upper respiratory tract diseases.

[Use of tissue adhesives in the reconstruction of the frontal sinus]. / Zastosowanie kleju do tkanek w rekonstrukcji zatoki czolowej.

Fractures of the anterior wall of the frontal sinus, complicated by impression of bone fragments, can cause serious functional and cosmetic disturbances. Surgeons often remove those fragments and obliterate the sinus. But disfigurement from the operation will be worse than that caused by original lesion and can only be corrected by further plastic surgery. Some surgeons use the technique of joining bone fragments by metal or thread sutures but it is only possible when the fragment are not too small. We present four patients treated over a period of 1975-1979 with the reconstruction of the frontal sinus from its fragments using cyanoacrylic tissue adhesive (Chirurcoll-Polfa). One patient was operated immediately after an accident, two patients one month after a trauma and another after six months. The adhesive tissue was applied in single drops directly on the edges of dry surface of bone fragments. The fragments can be joined only in some points because the tissue adhesive can not make an isolation layer between them. The tissue adhesive speeds up the processes of ossification. We observed no interference with wound healing, no detrimental effect of this method in the postoperative course and no pathologic local and general reactions. The adhesive tissue makes manipulation in the operative field easier. The functional and esthetic results were satisfactory and further corrective surgery was not necessary.

Incubations of testis myo-inositol-1-phosphate synthase with D-(5-18O)glucose 6-phosphate and with H218O show no evidence of Schiff base formation.

myo-Inositol-1-P synthase (EC 5.5.1.4) purified from rat testis and from bovine testis was allowed to react with D-[5-18O]glucose-6-P. myo-Inositol, obtained in these reactions, retained all of the 18O originally in the glucose-6-P. When these enzyme preparations were incubated with unlabeled glucose-6-P in a medium enriched in H2 18O no uptake of the oxygen isotope occurred that could be ascribed to the myo-inositol-1-P synthase reaction. By these criteria this enzyme, which is considered to use an aldolase mechanism in the cyclization step, cannot form a Schiff base during the reaction. In addition, these enzymes are not inhibited by 10 mM EDTA. One interpretation of this evidence is that the myo-inositol-1-P synthases we have studied are neither Class I nor Class II aldolases, and simply use base catalysis in the cyclization step.