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1.
Obstet Gynecol ; 142(5): 1044-1054, 2023 11 01.
Artigo em Inglês | MEDLINE | ID: mdl-37826848

RESUMO

OBJECTIVE: To explore how markers of health care disparity are associated with access to care and outcomes among patients seeking and undergoing hysterectomy for benign indications. DATA SOURCES: PubMed, EMBASE, and ClinicalTrials.gov were searched through January 23, 2022. METHODS OF STUDY SELECTION: The population of interest included patients in the United States who sought or underwent hysterectomy by any approach for benign indications. Health care disparity markers included race, ethnicity, geographic location, insurance status, and others. Outcomes included access to surgery, patient level outcomes, and surgical outcomes. Eligible studies reported multivariable regression analyses that described the independent association between at least one health care disparity risk marker and an outcome. We evaluated direction and strengths of association within studies and consistency across studies. TABULATION, INTEGRATION, AND RESULTS: Of 6,499 abstracts screened, 39 studies with a total of 46 multivariable analyses were included. Having a Black racial identity was consistently associated with decreased access to minimally invasive, laparoscopic, robotic, and vaginal hysterectomy. Being of Hispanic ethnicity and having Asian or Pacific Islander racial identities were associated with decreased access to laparoscopic and vaginal hysterectomy. Black patients were the only racial or ethnic group with an increased association with hysterectomy complications. Medicare insurance was associated with decreased access to laparoscopic hysterectomy, and both Medicaid and Medicare insurance were associated with increased likelihood of hysterectomy complications. Living in the South or Midwest or having less than a college degree education was associated with likelihood of prior hysterectomy. CONCLUSION: Studies suggest that various health care disparity markers are associated with poorer access to less invasive hysterectomy procedures and with poorer outcomes for patients who are undergoing hysterectomy for benign indications. Further research is needed to understand and identify the causes of these disparities, and immediate changes to our health care system are needed to improve access and opportunities for patients facing health care disparities. SYSTEMATIC REVIEW REGISTRATION: PROSPERO, CRD42021234511.


Assuntos
Disparidades em Assistência à Saúde , Medicare , Idoso , Feminino , Humanos , Estados Unidos , Histerectomia/métodos , Etnicidade , Histerectomia Vaginal , Estudos Retrospectivos
2.
Female Pelvic Med Reconstr Surg ; 26(5): 299-305, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-32324683

RESUMO

Although the peak incidence of surgery for pelvic floor disorders does not occur until after menopause, an increasing number of younger women are seeking treatment for these problems. Whereas most surgeons would recommend delaying surgery until the completion of childbearing, published cases and case series address outcomes after subsequent pregnancies in women who have been treated for urinary incontinence and pelvic organ prolapse. This document synthesizes the available evidence on the impact of pregnancy on women with prior treatment for pelvic floor disorders and on the impact of these prior treatments on subsequent pregnancy. Pregnancy after the repair of obstetrical anal sphincter laceration is also discussed. Consensus recommendations are presented based on available literature review and expert involvement.


Assuntos
Distúrbios do Assoalho Pélvico/cirurgia , Procedimentos de Cirurgia Plástica/efeitos adversos , Complicações na Gravidez/etiologia , Parto Obstétrico/efeitos adversos , Feminino , Humanos , Distúrbios do Assoalho Pélvico/complicações , Gravidez , Recidiva , Fatores de Risco , Slings Suburetrais/efeitos adversos
3.
Int Urogynecol J ; 30(9): 1433-1454, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31256222

RESUMO

INTRODUCTION AND HYPOTHESIS: Several posterior compartment surgical approaches are used to address posterior vaginal wall prolapse and obstructed defecation. We aimed to compare outcomes for both conditions among different surgical approaches. METHODS: A systematic review was performed comparing the impact of surgical interventions in the posterior compartment on prolapse and defecatory symptoms. MEDLINE, Embase, and ClinicalTrials.gov were searched from inception to 4 April 2018. Randomized controlled trials, prospective and retrospective comparative and single-group studies of women undergoing posterior vaginal compartment surgery for vaginal bulge or bowel symptoms were included. Studies had to include both anatomical and symptom outcomes both pre- and post-surgery. RESULTS: Forty-six eligible studies reported on six surgery types. Prolapse and defecatory symptoms improved with native-tissue transvaginal rectocele repair, transanal rectocele repair, and stapled transanal rectocele repair (STARR) surgeries. Although prolapse was improved with sacrocolpoperineopexy, defecatory symptoms worsened. STARR caused high rates of fecal urgency postoperatively, but this symptom typically resolved with time. Site-specific posterior repairs improved prolapse stage and symptoms of obstructed defecation. Compared with the transanal route, native-tissue transvaginal repair resulted in greater improvement in anatomical outcomes, improved obstructed defecation symptoms, and lower chances of rectal injury, but higher rates of dyspareunia. CONCLUSIONS: Surgery in the posterior vaginal compartment typically has a high rate of success for anatomical outcomes, obstructed defecation, and bulge symptoms, although these may not persist over time. Based on this evidence, to improve anatomical and symptomatic outcomes, a native-tissue transvaginal rectocele repair should be preferentially performed.


Assuntos
Constipação Intestinal/cirurgia , Procedimentos Cirúrgicos em Ginecologia/métodos , Prolapso de Órgão Pélvico/cirurgia , Retocele/cirurgia , Cirurgia Endoscópica Transanal/métodos , Vagina/cirurgia , Constipação Intestinal/etiologia , Feminino , Humanos , Prolapso de Órgão Pélvico/complicações , Guias de Prática Clínica como Assunto , Estudos Prospectivos , Ensaios Clínicos Controlados Aleatórios como Assunto , Retocele/complicações , Estudos Retrospectivos
4.
Female Pelvic Med Reconstr Surg ; 25(2): 149-153, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30807418

RESUMO

OBJECTIVE: In women with pelvic floor disorders, we sought to determine time-to-teach (TTT) correct pelvic floor muscle (PFM) contraction, prevalence of inappropriate muscle contractions, and the association between TTT with PFM strength (PFMS). METHODS: From August 2017 to April 2018, patients from 2 pelvic floor disorder clinics participated in a prospective study examining PFMS. Assessment of PFMS was performed to obtain TTT, inappropriate accessory muscle, and Modified Oxford Grading Scale scores for pelvic floor muscle contractions 1 to pelvic floor muscle contractions 2. RESULTS: Of 100 women, 77 were from low-resource setting and 23 from high-resource setting. Mean TTT overall was 64.1 seconds (±26.0; range, 9-160 seconds), and mean TTT between settings was not significant. Mean overall TTT was significantly less than 90 seconds. Seventy-one women (71%) demonstrated at least 1 inappropriate accessory muscle, and of those, up to 50% of patients contracting 2 accessory muscle groups with abdominal muscles most frequently contracted at baseline. Thirty-nine percent of patients had a PFM contraction of at least 3 at baseline compared with 82% of patients upon completion of teaching, with 60% of women with scores of 4 or 5. The mean difference overall between baseline and pelvic floor muscle contractions 3 was 1.27 (confidence interval, 1.08-1.46; P < 0.001), and this increase was significant. CONCLUSIONS: One-time PFMS teaching can be done in a time-proficient fashion and is translatable across high-resource and low-resource settings. Most patients show improvement in PFMS immediately and can quickly acquire this learned skill for proper home practice.


Assuntos
Terapia por Exercício , Educação de Pacientes como Assunto , Diafragma da Pelve/fisiopatologia , Prolapso de Órgão Pélvico/terapia , Incontinência Urinária/terapia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Exame Ginecológico , Humanos , Pessoa de Meia-Idade , Contração Muscular , Força Muscular , Prolapso de Órgão Pélvico/fisiopatologia , Estudos Prospectivos , Fatores de Tempo , Incontinência Urinária/fisiopatologia
5.
Female Pelvic Med Reconstr Surg ; 25(2): 154-156, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30807419

RESUMO

OBJECTIVE: In women who undergo provider-guided vaginal biofeedback of pelvic floor muscle strength, we sought to determine whether the level of the provider correlates with the patient's ability to achieve adequate pelvic floor muscle contractions (PFMCs). METHODS: From August 2017 to April 2018, patients from 2 urogynecology clinics were recruited to participate in an institutional review board-approved, prospective study examining PFMCs. Pelvic examination and teaching session were done by providers who had specific training on how to assess pelvic floor muscle strength using the validated, modified Oxford scale. Patients were asked to perform a baseline PFMC during a 2-digit pelvic examination. Thereafter, patients were counseled to relax their muscles, identify the levator ani muscles during provider teaching, and perform 3 consecutive provider-guided PFMCs. The strength of each PFMC was measured, and the time-to-teach (TTT) was recorded. The level of provider and TTT were correlated with PFMC1 to PFMC3 using Spearman correlation coefficient. RESULTS: One hundred women participated. Obstetrics/gynecology (OB/GYN) residents (post-graduate years 1-4) evaluated 20 patients; female pelvic medicine and reconstructive surgery fellowship trainees (post-graduate years 5-7), 38 patients; OB/GYN nurse practitioners, 18 patients; generalist OB/GYN faculty, 9 patients; and female pelvic medicine and reconstructive surgery faculty, 15 patients. There was no correlation between level of provider and TTT or between level of provider and strength of PFMC1, PFMC2, or PFMC3. CONCLUSIONS: At the time of pelvic floor muscle assessment, the level of provider does not impact teaching time or PFMC1 to PFMC3. Teaching pelvic floor muscle exercise is a cost-effective, low-resource tool to improve patient care, and providers of any level should be encouraged to teach pelvic floor muscle exercise to patients at the time of office examination.


Assuntos
Competência Clínica , Ginecologia , Pessoal de Saúde , Obstetrícia , Educação de Pacientes como Assunto/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Terapia por Exercício/educação , Docentes , Bolsas de Estudo , Feminino , Exame Ginecológico , Ginecologia/educação , Humanos , Internato e Residência , Pessoa de Meia-Idade , Contração Muscular , Força Muscular , Profissionais de Enfermagem , Obstetrícia/educação , Diafragma da Pelve/fisiologia , Prolapso de Órgão Pélvico/fisiopatologia , Prolapso de Órgão Pélvico/terapia , Estudos Prospectivos , Fatores de Tempo , Incontinência Urinária/fisiopatologia , Incontinência Urinária/terapia
6.
Female Pelvic Med Reconstr Surg ; 25(4): 289-293, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-29300258

RESUMO

OBJECTIVES: The aims of this study were to determine the efficacy of phenazopyridine when used intraoperatively to assess ureteral patency and to investigate factors that may influence its efficacy. METHODS: This is a retrospective chart review performed at the Olive View-UCLA Medical Center, a Los Angeles County teaching hospital, from January 2014 through July 2016. Patients undergoing cystoscopy at the time of gynecologic surgery were identified via department case logs. All women receiving preoperative oral phenazopyridine were included. If ureteral flow was unable to be visualized with phenazopyridine alone, the medication was deemed ineffective, and sodium fluorescein was given intraoperatively. Patients were divided into a phenazopyridine effective or phenazopyridine ineffective group. Patient demographics, renal function, intraoperative fluids and urine output, estimated blood loss, timing and dose of medication administration, and complications were gathered from the chart and compared between groups using Fisher exact test, 2-sample t test, Wilcoxon test, and logistic regression for multivariable analysis. P < 0.05 was determined to be significant. RESULTS: Preoperative phenazopyridine was effective in 190 (91.8%) of 207 patients. It was ineffective in 17 patients who then required intraoperative sodium fluorescein. The group in which phenazopyridine was effective was more likely to have been given a 200-mg (vs 100-mg) dose (P = 0.02) and had lower intraoperative urine output (median, 450 vs 800 mL; P = 0.002). CONCLUSIONS: Preoperative oral phenazopyridine is effective in more than 90% of cases to detect during gynecologic surgery. A higher phenazopyridine dose and lower intraoperative urine output were associated with increased efficacy.


Assuntos
Corantes , Complicações Intraoperatórias/diagnóstico , Fenazopiridina , Ferida Cirúrgica/diagnóstico , Ureter/lesões , Administração Oral , Adulto , Idoso , Corantes/administração & dosagem , Cistoscopia , Feminino , Fluoresceína , Procedimentos Cirúrgicos em Ginecologia/efeitos adversos , Humanos , Complicações Intraoperatórias/etiologia , Período Intraoperatório , Pessoa de Meia-Idade , Fenazopiridina/administração & dosagem , Período Pré-Operatório , Estudos Retrospectivos , Ferida Cirúrgica/etiologia , Urina
7.
Female Pelvic Med Reconstr Surg ; 23(5): 310-314, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28145915

RESUMO

OBJECTIVE: The aim of the study was to investigate the association between severity of anterior vaginal or apical prolapse and postvoid residual volume (PVR). METHODS: The charts of all women who presented to Urogynecology Clinic at Olive View-UCLA Medical Center for a 2-year period were reviewed. Demographic data, the degree of prolapse pelvic organ prolapse quantification points Aa, Ba, and C, and PVR were recorded. Patients with incomplete pelvic organ prolapse quantification assessment or improperly measured PVR were excluded. RESULTS: Three hundred fifty-two patients were included. Median age was 54 years (range, 26-80). Mean gravidity and parity were 4.4 and 3.7, respectively. Mean body mass index was 29.9 kg/m. One hundred forty-nine women had previous pelvic surgery. Median PVR was 25 mL, and 40 patients (11.4%) had a PVR of 100 mL or greater.Considering 15 potential PVR predictors, we found that the position of apex/cervix (point C) significantly correlated with an increase in PVR and also after controlling for the other significant covariates (rate of change b = 4.7% increase in PVR/cm, P = 0.0007). The other significant (P < 0.05) covariates were gravidity (5.7% per pregnancy), postmenopausal status (32.4%), and vaginal surgical history (61.4%). This was not true, however, for the anterior vaginal position (points Aa, Ba; P > 0.15). There was no difference in mean PVR in patients with versus without a hysterectomy (P = 0.236). CONCLUSIONS: Elevated PVR values have long been linked with prolapse of the anterior vaginal wall. We found that there is a linear association between PVR and the anatomic position of the apex. There was no association of PVR with the position of the anterior vaginal wall.


Assuntos
Retenção Urinária/etiologia , Prolapso Uterino/fisiopatologia , Vagina/fisiopatologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos de Casos e Controles , Feminino , Humanos , Pessoa de Meia-Idade , Paridade , Gravidez , Estudos Retrospectivos , Fatores de Risco , Índice de Gravidade de Doença , Urina , Prolapso Uterino/classificação , Prolapso Uterino/patologia , Prolapso Uterino/cirurgia
8.
Int Urogynecol J ; 26(4): 597-604, 2015 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25516231

RESUMO

INTRODUCTION AND HYPOTHESIS: Limited data exist on women's experience with pelvic organ prolapse (POP) symptoms. We aimed to describe factors that prevent disease understanding among Spanish-speaking and English-speaking women. METHODS: Women with POP were recruited from female urology and urogynecology clinics in Los Angeles, California, and Albuquerque, New Mexico. Eight focus groups were conducted, four in Spanish and four in English. Topics addressed patients' emotional responses when noticing their prolapse, how they sought support, what verbal and written information was given, and their overall feelings of the process. Additionally, patients were asked about their experience with their treating physician. All interview transcripts were analyzed using grounded theory qualitative methods. RESULTS: Qualitative analysis yielded two preliminary themes. First, women had misconceptions about what POP is as well as its causes and treatments. Second, there was a great deal of miscommunication between patient and physician which led to decreased understanding about the diagnosis and treatment options. This included the fact that women were often overwhelmed with information which they did not understand. The concept emerged that there is a strong need for better methods to achieve disease and treatment understanding for women with POP. CONCLUSIONS: Our findings emphasize that women with POP have considerable misconceptions about their disease. In addition, there is miscommunication during the patient-physician interaction that leads to further confusion among Spanish-speaking and English-speaking women. Spending more time explaining the diagnosis of POP, rather than focusing solely on treatment options, may reduce miscommunication and increase patient understanding.


Assuntos
Barreiras de Comunicação , Idioma , Educação de Pacientes como Assunto , Prolapso de Órgão Pélvico/diagnóstico , Prolapso de Órgão Pélvico/terapia , Mal-Entendido Terapêutico , Adulto , Idoso , Idoso de 80 Anos ou mais , Compreensão , Feminino , Grupos Focais , Humanos , Los Angeles , Pessoa de Meia-Idade , New Mexico , Prolapso de Órgão Pélvico/psicologia , Relações Médico-Paciente , Pesquisa Qualitativa
9.
Female Pelvic Med Reconstr Surg ; 19(3): 157-64, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23611934

RESUMO

OBJECTIVES: The purpose of our study was to evaluate barriers in communication and disease understanding among office staff and interpreters when communicating with Spanish-speaking women with pelvic floor disorders. METHODS: We conducted a qualitative study to evaluate barriers to communication with Spanish-speaking women with pelvic floor disorders among office staff and interpreters. Sixteen office staff and interpreters were interviewed; interview questions focused on experiences with Spanish-speaking patients with pelvic floor disorders in the clinic setting. Interview transcripts were analyzed qualitatively using grounded theory methodology. RESULTS: Analysis of the interview transcripts revealed several barriers in communication as identified by office staff and interpreters. Three major classes were predominant: patient, interpreter, and system-related barriers. Patient-related barriers included a lack of understanding of anatomy and medical terminology and inhibited discussions due to embarrassment. Provider-related barriers included poor interpreter knowledge of pelvic floor vocabulary and the use of office staff without interpreting credentials. System-related barriers included poor access to information. From these preliminary themes, an emergent concept was revealed: it is highly likely that Spanish-speaking women with pelvic floor disorders have poor understanding of their condition owing to multiple obstacles in communication. CONCLUSIONS: There are many levels of barriers to communications with Latin women treated for pelvic floor disorders, arising from the patient, interpreter, and the system itself. These barriers contribute to a low level of understanding of their diagnosis, treatment options, and administered therapies.


Assuntos
Barreiras de Comunicação , Hispânico ou Latino , Idioma , Distúrbios do Assoalho Pélvico , Feminino , Humanos , Masculino , Tradução , Estados Unidos
10.
Artigo em Inglês | MEDLINE | ID: mdl-23442506

RESUMO

OBJECTIVE: This study aimed to assess the effect of the initial visit with a specialist on disease understanding among Spanish-speaking women with pelvic floor disorders. METHODS: Spanish-speaking women with referrals suggestive of urinary incontinence (UI) and/or pelvic organ prolapse (POP) were recruited from public urogynecology clinics. Patients participated in a health literacy assessment and interview before and after their physician encounter. All interviews were analyzed using Grounded Theory qualitative methods. RESULTS: Twenty-seven women with POP (n = 6), UI (n = 11), and POP/UI (n = 10) were enrolled in this study. The mean age was 55.5 years, and most women had marginal levels of health literacy. From our qualitative analysis, 3 concepts emerged. First, was that patients had poor understanding of their diagnosis before and after the encounter regardless of how extensive the physician's explanation or level of Spanish-proficiency. Second, patients were overwhelmed with the amount of information given to them. Lastly, patients ultimately put their trust in the physician, relying on them for treatment recommendations. CONCLUSIONS: Our findings emphasize the difficulty Spanish-speaking women with low health literacy have in understanding information regarding pelvic floor disorders. In this specific population, the physician has a major role in influencing patients' treatment decisions and helping them overcome fears they may have about their condition.


Assuntos
Comunicação , Compreensão , Hispânico ou Latino , Distúrbios do Assoalho Pélvico , Adulto , Idoso , Aconselhamento , Tomada de Decisões , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Letramento em Saúde , Humanos , Pessoa de Meia-Idade , Distúrbios do Assoalho Pélvico/diagnóstico , Distúrbios do Assoalho Pélvico/terapia , Relações Médico-Paciente
11.
Int Urogynecol J ; 24(6): 939-46, 2013 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-23208002

RESUMO

INTRODUCTION AND HYPOTHESIS: Little is known about women's experience with conservative management of pelvic organ prolapse. We sought to understand the experiences of Spanish-speaking women who choose a pessary. METHODS: Spanish-speaking women from a urogynecological pessary clinic were recruited for this study. Interviews were conducted and the women were asked about their pessary experience including questions involving symptom relief, pessary management, and quality of life. All interview transcripts were analyzed using the qualitative methods of grounded theory. RESULTS: Sixteen Spanish-speaking women who had been using a pessary for at least 1 month were enrolled in this study. Grounded theory methodology yielded several preliminary themes, in which one major concept emerged as a pessary adjustment process. In this process patients had to first decide to use a pessary, either because of physician's recommendations or out of personal choice. Second, the patients entered an adjustment period in which they learned to adapt to the pessary, both physically and mentally. Lastly, if the patients properly adjusted to wearing a pessary they experienced relief of bothersome symptoms. CONCLUSIONS: Our findings demonstrate that Spanish-speaking women go through a process in order to adjust to a pessary. Furthermore, the physician plays a major role in not only determining a woman's decision to use a pessary, but also whether she can adjust to wearing the pessary. This process is most successful when patients receive comprehensive management from a healthcare team of physicians and nurses who can provide individualized and continuous pessary care.


Assuntos
Hispânico ou Latino/etnologia , Prolapso de Órgão Pélvico/etnologia , Prolapso de Órgão Pélvico/terapia , Pessários , Idoso , Idoso de 80 Anos ou mais , Tomada de Decisões , Gerenciamento Clínico , Feminino , Hispânico ou Latino/psicologia , Humanos , Entrevistas como Assunto , Pessoa de Meia-Idade , Prolapso de Órgão Pélvico/psicologia , Relações Médico-Paciente , Qualidade de Vida/psicologia , Resultado do Tratamento
12.
Obstet Gynecol Clin North Am ; 36(3): 445-62, 2009 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-19932409

RESUMO

Pelvic floor disorders are common health issues for women and have a great impact on quality of life. These disorders can present with a wide spectrum of symptoms and anatomic defects. This article reviews the clinical approach and office evaluation of patients with pelvic floor disorders, including pelvic organ prolapse, urinary dysfunction, anal incontinence, sexual dysfunction, and pelvic pain. The goal of treatment is to provide as much symptom relief as possible. After education and counseling, patients may be candidates for non-surgical or surgical treatment, and expectant management.


Assuntos
Prolapso de Órgão Pélvico/diagnóstico , Incontinência Fecal/diagnóstico , Incontinência Fecal/etiologia , Feminino , Humanos , Visita a Consultório Médico , Diafragma da Pelve , Prolapso de Órgão Pélvico/fisiopatologia , Dor Pélvica/diagnóstico , Dor Pélvica/etiologia , Disfunções Sexuais Fisiológicas/diagnóstico , Disfunções Sexuais Fisiológicas/etiologia , Transtornos Urinários/diagnóstico , Transtornos Urinários/etiologia
13.
Biol Reprod ; 80(3): 407-14, 2009 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-18987327

RESUMO

Two mouse models of pelvic organ prolapse have been generated recently, both of which have null mutations in genes involved in elastic fiber synthesis and assembly (fibulin 5 and lysyl oxidase-like 1). Interestingly, although these mice exhibit elastinopathies early in life, pelvic organ prolapse does not develop until later in life. In this investigation we developed and validated a tool to quantify the severity of pelvic organ prolapse in mice, and we used this tool prospectively to study the role of fibulin 5, aging, and vaginal proteases in the development of pelvic organ prolapse. The results indicate that >90% of Fbln5(-/-) mice develop prolapse by 6 mo of age, even in the absence of vaginal delivery, and that increased vaginal protease activity precedes the development of prolapse.


Assuntos
Proteínas da Matriz Extracelular/metabolismo , Metaloproteinase 2 da Matriz/metabolismo , Metaloproteinase 9 da Matriz/metabolismo , Proteínas Recombinantes/metabolismo , Índice de Gravidade de Doença , Prolapso Uterino/metabolismo , Vagina/metabolismo , Envelhecimento/metabolismo , Animais , Tecido Elástico/metabolismo , Proteínas da Matriz Extracelular/genética , Feminino , Camundongos , Camundongos Knockout , Modelos Animais , Variações Dependentes do Observador , Proteínas Recombinantes/genética , Prolapso Uterino/fisiopatologia , Vagina/fisiopatologia
14.
Biol Reprod ; 78(3): 521-8, 2008 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-18003950

RESUMO

Recent evidence indicates that failure of elastic fiber assembly and synthesis is involved in the pathophysiology of pelvic organ prolapse in mice. It has been long been hypothesized that parturition-induced activation of proteases in the vaginal wall and its supportive tissues may contribute to pelvic organ prolapse in women. In this investigation, we determined the expression of matrix metalloproteases with elastase activity (matrix metalloproteinase [MMP] 2, MMP9, and MMP12) and their inhibitors in the vaginal wall of nonpregnant, pregnant, and postpartum mice. Data obtained using mRNA levels and enzyme activity measurements indicate that MMP2, MMP9, and 21- to 24-kDa caseinolytic serine proteases are regulated in vaginal tissues from pregnant and postpartum mice. Although suppressed during pregnancy and the early postpartum time period, MMP2 and MMP9 enzyme activities are increased after 48 h, a time when mRNA levels of protease inhibitors (tissue inhibitor of MMP2 [Timp2], cystatin C [Cst3], and alpha-1 antitrypsin [Serpina1]) are decreased. We conclude that recovery of the vaginal wall from pregnancy and parturition requires increased elastic fiber assembly and synthesis to counteract the marked increase in elastolytic activity of the postpartum vagina.


Assuntos
Regulação Enzimológica da Expressão Gênica , Metaloproteinases da Matriz/genética , Metaloproteinases da Matriz/metabolismo , Elastase Pancreática/metabolismo , Parto/genética , Período Pós-Parto/genética , Vagina/enzimologia , Animais , Feminino , Metaloproteinase 2 da Matriz/genética , Metaloproteinase 2 da Matriz/metabolismo , Metaloproteinase 9 da Matriz/genética , Metaloproteinase 9 da Matriz/metabolismo , Camundongos , Camundongos Endogâmicos C57BL , Elastase Pancreática/genética , Parto/metabolismo , Período Pós-Parto/metabolismo , Gravidez , Inibidor Tecidual de Metaloproteinase-1/genética , Inibidor Tecidual de Metaloproteinase-1/metabolismo , Inibidor Tecidual de Metaloproteinase-2/genética , Inibidor Tecidual de Metaloproteinase-2/metabolismo , Vagina/metabolismo
15.
Am J Obstet Gynecol ; 197(6): 658.e1-5, 2007 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-18060970

RESUMO

OBJECTIVE: The objective of the study was to characterize the anatomy of the internal iliac artery (IIA) and its posterior division branches and to correlate these findings to IIA ligation. STUDY DESIGN: Dissections were performed in 54 female cadavers. RESULTS: Average length of IIA was 27.0 (range, 0-52) mm. Posterior division arteries arose from a common trunk in 62.3% (66 of 106) of pelvic halves. In the remaining specimens, branches arose independently from the IIA, with the iliolumbar noted as the first branch in 28.3%, lateral sacral in 5.7%, and superior gluteal in 3.8%. The average width of the first branch was 5.0 (range, 2-12) mm. In all dissections, posterior division branches arose from the dorsal and lateral aspect of IIA. The internal iliac vein was lateral to the artery in 70.6% (12 of 17) of specimens on the left and 93.3% (14 of 15) on the right. CONCLUSION: Ligation of the IIA 5 cm distal from the common iliac bifurcation would spare posterior division branches in the vast majority of cases. Understanding IIA anatomy is essential to minimize intra-operative blood loss and other complications.


Assuntos
Artéria Ilíaca/anatomia & histologia , Idoso , Idoso de 80 Anos ou mais , Cadáver , Dissecação , Feminino , Humanos , Artéria Ilíaca/cirurgia , Ligadura , Pessoa de Meia-Idade
16.
Am J Obstet Gynecol ; 197(6): 660.e1-6, 2007 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-18060971

RESUMO

OBJECTIVE: The objective of the study was to further characterize the anatomy of the coccygeus muscle-sacrospinous ligament (C-SSL) complex and to correlate the findings with sacrospinous ligament fixations (SSLF). STUDY DESIGN: Dissections were performed in 21 female cadavers. RESULTS: In all dissections, nerves originating from S3, S4, S5, or a combination passed over the anterior surface of the C-SSL at its midsegment, and either the pudendal or third sacral nerve coursed on the superior border of C-SSL at its midpoint. In 100% of specimens, the internal pudendal artery (IPA) passed behind or just medial to the ischial spine. The average distance of the inferior gluteal artery (IGA) from the ischial spine and the superior border of the C-SSL was 24.2 (range, 15-35) mm and 3.4 (range, 1-5) mm, respectively. CONCLUSION: Nerves to the coccygeus and levator ani coursed over the midportion of the C-SSL where SSLF sutures are placed. The pudendal nerve and IGA were in proximity to the superior border of the C-SSL at its midportion, whereas the IPA passed behind the ischial spine, lateral to the recommended site for suture placement.


Assuntos
Ligamentos/anatomia & histologia , Região Sacrococcígea/anatomia & histologia , Idoso , Idoso de 80 Anos ou mais , Cadáver , Feminino , Procedimentos Cirúrgicos em Ginecologia , Humanos , Ligamentos/irrigação sanguínea , Ligamentos/inervação , Ligamentos/cirurgia , Região Sacrococcígea/irrigação sanguínea , Região Sacrococcígea/inervação
17.
Am J Obstet Gynecol ; 197(6): 668.e1-4, 2007 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-18060975

RESUMO

OBJECTIVE: The objective of the study was to examine the relationship of the ureter to paravaginal defect repair (PVDR) sutures and to evaluate the anatomy of distal ureter, trigone, and urethra relative to the anterior vaginal wall. STUDY DESIGN: Dissections of the retropubic space were performed in 24 unembalmed female cadavers following placement of PVDR sutures. Lengths of the vagina, urethra, and trigone were recorded. RESULTS: The mean distance between apical PVDR sutures and the ureter was 22.8 (range, 5-36) mm. The average lengths of the urethra, trigone, and vagina were 3 cm, 2.8 cm, and 8.4 cm, respectively. The trigone was positioned over the middle third of the anterior vaginal wall in all specimens and the distal ureters traversed the anterolateral vaginal fornices. CONCLUSION: The ureters may be injured during paravaginal defect repairs, anterior colporrhaphies, and other procedures involving dissection in the upper third of the vagina. Cystotomy during vaginal hysterectomies is most likely to occur 2-3 cm above the trigone.


Assuntos
Procedimentos Cirúrgicos em Ginecologia/efeitos adversos , Técnicas de Sutura/efeitos adversos , Ureter/anatomia & histologia , Uretra/anatomia & histologia , Bexiga Urinária/anatomia & histologia , Vagina/anatomia & histologia , Idoso , Idoso de 80 Anos ou mais , Cadáver , Feminino , Humanos , Histerectomia Vaginal/efeitos adversos
18.
Am J Obstet Gynecol ; 197(6): 672.e1-6, 2007 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-18060977

RESUMO

OBJECTIVE: The objective of the study was to characterize anatomic relationships of uterosacral ligament suspension (USLS) sutures. STUDY DESIGN: The relationship of USLS sutures to the ureters, rectal lumen, and sidewall neurovascular structures was examined in 15 unembalmed female cadavers. RESULTS: The mean distance of the proximal sutures to the ureters and rectal lumen was 14 mm (range, 0-33) and 10 mm (range, 0-33), respectively. The mean distance of the distal sutures to the ureters was 14 mm (range, 4-33) and to the rectal lumen 13 mm (range, 3-23). Right sutures were noted at the level of S1 in 37.5%, S2 in 37.5%, and S3 in 25% of specimens. Left sutures were noted at the level of S1 in 50%, S2 in 29.2%, and S3 in 20.8% of cadavers. Of 48 sutures passed, 1 entrapped the S3 nerve. Sutures perforated the pelvic sidewall vessels in 4.1% of specimens. CONCLUSION: USLS sutures can directly injure the ureters, rectum, and neurovascular structures in the pelvic walls.


Assuntos
Ligamentos/cirurgia , Reto/anatomia & histologia , Ureter/anatomia & histologia , Útero/cirurgia , Idoso , Idoso de 80 Anos ou mais , Vasos Sanguíneos/lesões , Cadáver , Feminino , Procedimentos Cirúrgicos em Ginecologia/efeitos adversos , Humanos , Plexo Lombossacral/lesões , Reto/lesões , Região Sacrococcígea/irrigação sanguínea , Região Sacrococcígea/inervação , Técnicas de Sutura , Ureter/lesões
19.
Am J Obstet Gynecol ; 195(6): 1736-41, 2006 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-17132475

RESUMO

OBJECTIVE: The purpose of this study was to characterize the vascular anatomy of the female presacral space (PSS) and to correlate findings to the abdominal sacrocolpopexy. STUDY DESIGN: Detailed dissections of the PSS were performed in 52 unembalmed female cadavers. RESULTS: The closest cephalad vessel to the mid sacral promontory (MSP) was the left common iliac vein (LCIV), mean distance 27 mm (9-52 mm). The closest vessel lateral to MSP was also the LCIV, mean distance 22 mm (9-35 mm). The average distance of the middle sacral artery and vein to the MSP was 4 mm (0-15 mm) and 7 mm (0-17 mm), respectively. The mean distance of the sacral venous plexuses to the MSP was 34 mm (4-86 mm). CONCLUSION: Anatomic location of the vascular boundaries and contents of the PSS is highly variable. Careful dissection and exposure of the anterior longitudinal ligament of the sacrum before suture placement should minimize potentially life-threatening vascular complications.


Assuntos
Região Sacrococcígea/irrigação sanguínea , Idoso , Idoso de 80 Anos ou mais , Artérias/anatomia & histologia , Vasos Sanguíneos/anatomia & histologia , Cadáver , Feminino , Humanos , Veia Ilíaca/anatomia & histologia , Pessoa de Meia-Idade , Veias/anatomia & histologia
20.
J Vasc Surg ; 35(6): 1218-25, 2002 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-12042734

RESUMO

BACKGROUND: The current status and future needs of peripheral endovascular utilization and training have not been well defined. This topic is particularly relevant to the future of four specialties: interventional cardiology, cardiothoracic surgery, interventional radiology, and peripheral vascular surgery. We attempt to analyze the current numbers of cardiovascular patients and procedures and the numbers of treating physicians and surgeons to make predictions and recommendations for the future. METHODS: The numbers of cardiovascular patients and procedures were obtained from the Healthcare Cost and Utilization Project Trend Query web site. The number of endovascular abdominal aortic aneurysm repairs was obtained with telephone or e-mail contact with the aortic endograft manufacturers. The numbers of different cardiovascular specialists were obtained with contact with different cardiovascular professional societies and the American Board of Specialists via telephone, e-mail, or web site. The numbers of accredited US cardiovascular fellowship programs and first year spots were obtained from the Graduate Medical Education Directory 2000 to 2001. Finally, the numbers of endovascular fellowship programs and first year spots were obtained with contact with the individual programs. RESULTS: The numbers of cardiovascular patients and procedures have risen from 1993 to 1997. This trend is expected to continue as the population ages. Despite the rapid rise of endovascular procedures, the number of open cases has continued to rise as well. However, the number of cardiovascular specialists is predicted to remain stable. Specific numbers and trends are depicted in the manuscript. CONCLUSION: Our analysis shows that a critical shortage of endovascular trained specialists will exist in the future. More surgeons need to receive endovascular training to meet these future needs.


Assuntos
Cardiologia/tendências , Doenças Vasculares Periféricas/terapia , Radiografia Intervencionista/tendências , Especialidades Cirúrgicas , Cirurgia Torácica/tendências , Procedimentos Cirúrgicos Vasculares/tendências , Humanos , Especialidades Cirúrgicas/tendências , Estados Unidos , Recursos Humanos
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