Risk factors of peripheral arterial disease: a case control study in Sri Lanka.

BACKGROUND: Peripheral artery disease (PAD) is an important global health problem and contributes to notable proportion of morbidity and mortality. This particular manifestation of systemic atherosclerosis is largely under diagnosed and undertreated. For sustainable preventive strategies in a country, it is mandatory to identify country-specific risk factors. We intended to assess the risk factors of PAD among adults aged 40-74 years. METHODS: This case control study was conducted in 2012-2013 in Sri Lanka. Seventy-nine cases and 158 controls in the age group of 40-74 years were selected for the study in order to have case to control ratio 1:2. The criterion for selecting cases and control was based on Ankle brachial pressure index (ABPI). Cases were selected from those who had ABPI 0.85 or less (ABPI ≤0.85) in either lower limb. Controls were selected from those ABPI score between 1.18 and 1.28 in both lower limbs. Only newly identified individuals with PAD were selected as cases. Controls were selected from the same geographical location and within the 5 year age group as cases. RESULTS: The history of diabetes mellitus more than 10 years (OR 5.8, 95% CI 2.2-14.2), history of dyslipidemia for more than 10 years (OR 4.9, 95% CI 2.1-16.2), history of hypertension for more than 10 years (OR 3.8, 95% CI 1.8-12.7) and smoking (OR 2.9, 95% CI 1.2-6.9), elevated HsCRP (OR 3.7, 95% CI 1.2-12.0) and hyperhomocysteinemia (OR 3.0, 95% CI 1.1-8.1) were revealed as country specific significant risk factor of PAD. CONCLUSIONS: Diabetes mellitus, hypertension, dyslipidemia, smoking as well as elevated homocysteine and HsCRP found as risk factors of PAD. Longer the duration or higher level exposure to these risk factors has increased the risk of PAD. These findings emphasis the need for routine screening of PAD among patients with the identified risk factors.

Gaps in awareness of peripheral arterial disease in Sri Lanka: a cross sectional study.

BACKGROUND: Peripheral arterial disease (PAD) is an emerging problem in Sri Lanka, particularly with the ageing population. A considerable number of patients are detected at a late stage with severe limb ischemia or chronic non-healing leg ulceration. Public awareness about PAD is important in developing preventive strategies. METHODS: A cross sectional study was conducted to assess awareness of PAD among adults aged 40-74 years in a district in Sri Lanka. In total, 2912 adults were selected for the study using a multistage probability proportionate to size sampling technique. Data were collected by an interviewer-administered questionnaire. Participants who were aware of PAD were asked about common risk factors, possible consequences of untreated PAD, and sources of information. Multivariate logistic regression analysis was used to assess the independent predictors of PAD awareness. RESULTS: We found that 4.1 % of participants were aware of PAD (95 % confidence interval: 3.4-4.8), which was significantly lower than awareness of other cardiovascular diseases such as cerebrovascular accidents (67.3 %) and myocardial infarction (57.6 %) (p < 0.001). Being male, an urban resident, and having a higher level of education were independent predictors of high PAD awareness. CONCLUSIONS: Our findings suggest that a comprehensive PAD awareness program that covers risk factors, consequences, and preventative strategies is needed to enhance public awareness of PAD.

ABPI against Colour Duplex Scan: A Screening Tool for Detection of Peripheral Arterial Disease in Low Resource Setting Approach to Validation.

Background. In Sri Lanka the ABPI has not been used as a screening tool to detect peripheral arterial disease (PAD) in epidemiological studies. This study was conducted to determine the best cutoff value of ABPI to detect PAD in Sri Lankan population. Methods. The ABPI measured by arterial Doppler to detect PAD was validated against colour duplex scan as the criterion using 165 individuals referred to vascular laboratory, National Hospital Sri Lanka. In all selected individuals ABPI was measured and lower limb colour duplex scan was performed. Narrowing of luminal diameter of lower limb arteries 50% or more was considered as haemodynamically significant and having PAD. The discriminative performance of the ABPI was assessed using Receiver Operator Characteristic (ROC) curve and calculating the area under the curve (AUC). The sensitivity and specificity of different threshold levels of ABPI and the best cutoff value of ABPI to detect PAD were determined. Results. ABPI 0.89 was determined as the best cutoff value to identify individuals with PAD. At this level of ABPI high sensitivity (87%), specificity (99.1%), positive predictive value (98.9%), and negative predictive value (88.4%) were observed. Conclusion. ABPI ≤ 0.89 could be used as the best cut off value to detect PAD.

Challenges in the management of extremity vascular injuries: A wartime experience from a tertiary centre in Sri Lanka.

BACKGROUND: Management of peripheral vascular injuries often present critical challenges in resource limited settings of developing countries. The additional burden from a military conflict poses further challenges. Delays in presentation often result in the loss of limb and even life, in what is usually a young active population. The objective of this report is to analyse the early outcome of vascular intervention at a tertiary referral centre in Sri Lanka. METHODS: A retrospective descriptive review of eighty one consecutive extremity vascular injuries in seventy patients during a seven month period was performed with regards to the cause of injury, types of presentations, ischaemia time, interventional procedures, complications and early outcome. RESULTS: Mean age was 31.2 years (9-72 years) and 96% were males. Injuries were caused by blasts in 41%, cuts in 26%, gunshots in 17% and road traffic injuries in 9%. Indications for revascularization were acute ischaemia in 44%, active bleeding in 43% and pseudo-aneurysms in 13%. Six patients underwent primary amputations due to non-viable limbs. 64 patients underwent vascular intervention. Fifty one percent needed vein grafts while 46% had direct repairs. Bleeding was often (73%) from upper extremity injuries. Median time to revascularization was 5.5 (2-16) hours with all limbs salvaged. Acute ischaemia (40%) was often from popliteal injuries. Median time to revascularization was 10 (5-18) hours and viability was prejudged at fasciotomy. 92% of revascularized limbs were salvaged. There was no perioperative mortality. CONCLUSIONS: Results from vascular repairs are encouraging despite significant delays.

Blunt carotid injury from a penetrating stick: an unexpected injury.

Unattended blunt carotid injury (BCI) has stroke high risk of stroke and screening based on injury probability is recommended. Penetrating forces are not considered high risk and concomitant BCI would go unattended. The authors report a case of a 48-year-old man who fell out of a tree on to an upright stick that penetrated his lateral neck. He presented with impalement, which was removed after surgically laying open the entire wound. The carotid sheath had been breached and the internal jugular vein was bleeding. The adjacent common carotid artery was intact and pulsating with no external evidence of injury. However, injury proximity led to vascular imaging that demonstrated intimal disruption without thrombus or stenosis. Although he remained asymptomatic on heparin, the injury progressed to cause significant lumen stenosis. Endovascular stenting re-established the vessel lumen and he remains well on aspirin 9 months later. Awareness that penetrating neck trauma may cause BCIs is important.

Minimal access is not maximal safety: pelviureteric necrosis following percutaneous chemical lumbar sympathectomy.

Lumbar sympathectomy remains popular in the treatment of a variety of painful and circulatory conditions of the lower extremities. Although percutaneous chemical lumbar sympathectomy (PCLS) under radiographic guidance is minimally invasive and has decreased the need for open surgical sympathectomy, inadvertent damage to neighbouring structures is a matter for concern. We report the case of a 38-year-old man with thromboangiitis obliterans who had PCLS under radiographic guidance for relief of ischaemic rest pain that was complicated by necrotic disruption of the left pelviureteric region. The kidney was salvaged with an ureterocalycostomy and he remains well 4 years later. Such complications point to imprecise and unpredictable spread of the injected chemical too far beyond the needle tip. It is possible that such complications are often under reported and, therefore, not taken into consideration during informed consent. Precise neurolysis with laser and radiofrequency may be a safer alternative.

Relationship of carotid plaque echomorphology to presenting symptom.

BACKGROUND: Attempts to stratify carotid plaques according to clinical risk using single longitudinal view (SLV) echomorphology have not been uniformly successful. We compared SLV grey scale median measurements (SLV-GSM) with a newer technique of multiple cross-sectional view echomorphology (MCSV-GSM) in carotid plaques from 3 patient groups (asymptomatic, ocular, and hemispheric symptoms). METHODS: SLV and MCSV images were obtained from 109 carotid stenoses (70-99%; 41 hemispheric, 17 ocular, 51 asymptomatic). SLV-GSM and MCSV-GSM(min) (lowest plaque MCSV image GSM) were determined to assess echolucency whilst MCSV-GSM(max-min) (highest minus lowest MCSV-GSM) assessed heterogeneity. RESULTS: Echolucency was greater (lower GSM) in plaques causing hemispheric symptoms versus asymptomatic plaques (MCSV-GSM(min), P = .002; SLV-GSM, P = .002). Only MCSV imaging detected differences in echolucency between asymptomatic plaques and those causing ocular symptoms (SLV-GSM, p = 0.84; MCSV-GSM(min), p = .003). Symptomatic plaques showed greater heterogeneity versus asymptomatic plaques, significantly in those causing ocular symptoms (hemispheric P = .126; AF P = .011). CONCLUSIONS: Both SLV and MCSV echomorphology confirm increased echolucency in plaques causing hemispheric symptoms. Plaques causing ocular symptoms could only be distinguished from asymptomatic plaques with MCSV assessment (increased echolucency and heterogeneity). This suggests that amaurosis fugax may be associated with a more focal plaque instability that is best detected with MCSV imaging.

Jugular venous neurone specific enolase (NSE) increases following carotid endarterectomy under general, but not local, anaesthesia.

INTRODUCTION: Previous studies indicate that local (LA) rather than general anaesthesia (GA) for carotid endarterectomy (CEA) is associated with reflex hypertension and preservation of cerebral cytochrome oxidase after carotid clamping. The hypothesis that LA offers protection against ischaemic cerebral injury has been investigated by measuring ipsilateral jugular venous neurone specific enolase (NSE: neuronal glycolytic enzyme) and S-100B (glial cell protein) during and after CEA. METHODS: 27 patients with symptomatic carotid artery disease (70-99% stenosis) underwent CEA, 14 under LA and 13 under GA. Jugular venous blood samples were assayed for NSE and S-100B before carotid clamping and at 5min before and 5min, 2, 4, 6, 8, 12 and 24h after clamp release. RESULTS: No neurological complications occurred. S-100B levels were low and did not increase from baseline in either group. Pre-clamp NSE levels were similar in both groups (LA: 17.6 (15.2-20.7)microg/l, GA: 21.5 (11.3-26.2)microg/l; p=0.37) but increased significantly 2h after clamp release in GA patients (LA: 25.5 (16.6-27.8)microg/l, GA: 48.2 (31.4-61.3)microg/l, p=0.05) with a significant rise from baseline in GA patients (p=0.04). CONCLUSIONS: CEA performed under GA is associated with greater rises in jugular venous NSE, and hence cerebral injury, than CEA performed under LA.

Endovascular stenting of a persistent sciatic artery aneurysm via retrograde popliteal approach: a durable option.

We report a case of acute lower limb ischaemia caused by a persistent sciatic artery aneurysm in a 55-year-old woman who was successfully managed by endovascular stenting via a retrograde popliteal approach. Four years following the procedure, she remains well, confirming the durability of the endovascular option.

Revascularisation in diabetic "small vessel disease" of lower limbs: is it worthwhile?

BACKGROUND: Diabetic patients with critical ischaemia of the lower limb despite a palpable popliteal pulse are presumed to have 'small vessel disease' that is unreconstructable and often subjected to major amputation. Results of revascularisation in such patients are presented. METHODS: A prospective observational study of revascularisation [n = 23, 14 men, mean age 62 years (range 47 to 80)] using saphenous vein to bypass occluded infrapopliteal arteries in diabetics with critical leg ischaemia over a 5-year period. OUTCOME MEASURES: Surgical mortality, graft patency, major amputation rate, time taken for healing, ambulation after discharge from hospital. RESULTS: There was one death within 30 days of surgery. 2/4 early thromboses were salvaged, 5 (5/22) limbs were amputated. Limb salvage was 17/23 (74%). Two limbs were amputated because of thrombosis and 3 were amputated for spreading sepsis despite a patent graft. 2 late graft failures were detected but the limbs remain healed and functional. 15/23 (65%) re-vascularisations remained patent at a mean follow up of 30 months (range 4 to 60). Mean wound healing time was 30 days (range 16 to 45). 14/17 (82%) of those with salvaged limbs were independent with regard to ambulation. CONCLUSION: Bypass of diabetic small vessel disease of the lower limbs is feasible and effective in preventing major amputation and maintaining independent mobility.

A new method for characterizing carotid plaque: multiple cross-sectional view echomorphology.

PURPOSE: This study compares the ability of computer-derived B-mode ultrasound gray-scale measurements from a single longitudinal view (SLV) versus multiple cross-sectional views (MCSV) to differentiate symptomatic from asymptomatic carotid plaque causing more than 70% stenosis. METHOD: Seventy-four internal carotid artery (ICA) stenoses (70%-99%; 33 asymptomatic, 41 symptomatic within 3 months) were imaged to obtain the "best" SLV and five to eight MCSV images at 5 mm intervals from the carotid bifurcation. Digitized sonograms were computerized and normalized to the gray scale median (GSM) of blood (0) and vessel adventitia (200). Plaque GSM was determined for each frame (image analysis, MATLAB 5.3). General risk factors for stroke and plaque echogenicity (SLV GSM; minimum MCSV GSM; cross-sectional axial heterogeneity (highest minus lowest MCSV GSM) were determined for each group. RESULTS: Risk factors for stroke were similar in both groups, as was mean SLV GSM: symptomatic, 34 (95% confidence interval [CI], 24.8-43.0), asymptomatic, 43 (CI, 32.6-53.2); P =.1. Minimum MCSV GSM was lower for symptomatic plaque: 7 (CI, 4.2-9.8] vs 18.3 (CI, 12.2-24.5); P =.002. Greater axial GSM heterogeneity was present in symptomatic plaque: 34.5 (CI, 27.2-41.9) vs 16 (CI, 11.0-20.8); P =.0001. CONCLUSIONS: MCSV cross-sectional imaging that enables objective assessment of regional plaque echolucency and heterogeneity is more sensitive than SLV sonography for differentiating symptomatic from asymptomatic plaque.

The swollen leg: is it deep vein thrombosis? The experience of a tertiary referral center in Sri Lanka.

INTRODUCTION: The role played by deep vein thrombosis (DVT) as a cause of leg swelling in Sri Lanka is unknown. PURPOSE: To study the prevalence of proximal DVT, value of risk factors and clinical features and attitudes of clinicians towards diagnosis and treatment of DVT among those presenting with leg swelling as the main complaint. DESIGN: Prospective consecutive referrals to the University Surgical Unit, Colombo, over 10 months starting in January 1998. INCLUSION CRITERIA: DVT suspects with swollen legs. EXCLUSION CRITERIA: Varicose veins, leg ulceration and generalized oedema. METHODS: Color duplex scanning of the proximal deep veins and the superficial veins to detect occlusion and reflux. Information on previous diagnoses and treatment were obtained from the medical records. RESULTS: 63/137 (45%) had deep venous causes for oedema. Fever with rigors and inguinal lymphaedenopathy were strongly predictive of non DVT causes. Filariasis is the first diagnosis and DVT is considered late among the outpatients. CONCLUSIONS: DVT is a common cause of leg swelling among those referred.

Differences in the detection of cyclo-oxygenase 1 and 2 proteins in symptomatic and asymptomatic carotid plaques.

BACKGROUND: The expression of cyclo-oxygenase (COX) 1 and 2 has been demonstrated in atherosclerotic arteries. In the present study this was correlated with symptoms arising from a carotid plaque. METHODS: Carotid plaques from 12 asymptomatic patients were compared with 11 plaques from patients who had had neurological symptoms within the preceding 30 days. Sections were stained with haematoxylin and eosin, elastin van Gieson and goat antihuman antibodies to COX-1 and COX-2. Plaque morphology was correlated with neurological symptoms. The area with positive COX-1 and COX-2 staining was measured by computerized planimetry in entire cross-sections and in specific areas of the plaque. RESULTS: There was a significant association between cap thinning and plaque rupture with symptoms (P = 0.003). The percentage area of positive staining in entire cross-sections for both COX-1 and COX-2 was significantly greater in symptomatic plaques (P = 0.001 and 0.0004 respectively). Staining in symptomatic plaques was significantly greater in the cap (COX-1: P = 0.001; COX-2: P = 0.0001) and shoulder (COX-1: P = 0.008; COX-2: P = 0.007) regions of the plaque. COX-1 expression in the sclerotic area was not increased (P = 0.15) although COX-2 staining was significantly greater (P = 0.04). CONCLUSION: Both COX-1 and COX-2 detection was increased in symptomatic plaques. COX may contribute to plaque rupture and the onset of symptoms.