The current 'dramatically' high paternal ages at childbirth are not unprecedented.

There is strong individual-level evidence that late fatherhood is related to a wide range of health disorders and conditions in offspring. Over the last decades, mean paternal ages at childbirth have risen drastically. This has alarmed researchers from a wide range of fields. However, existing studies have an important shortcoming in that they lack a long-term perspective. This article is a step change in providing such a long-term perspective. We unveil that in many countries the current mean paternal ages at childbirth and proportions of fathers of advanced age at childbirth are not unprecedented. Taking the detected U-shaped trend pattern into account, we discuss individual- and population-level implications of the recent increases in paternal ages at childbirth and highlight important knowledge gaps. At the individual level, some of the biological mechanisms that are responsible for the paternal age-related health risk might, at least to some degree, be counterbalanced by various social factors. Further, how these individual-level effects are linked to population health and human cognitive development might be influenced by various factors, including technical advances and regulations in prenatal diagnostics.

Reproductive inequality in humans and other mammals.

To address claims of human exceptionalism, we determine where humans fit within the greater mammalian distribution of reproductive inequality. We show that humans exhibit lower reproductive skew (i.e., inequality in the number of surviving offspring) among males and smaller sex differences in reproductive skew than most other mammals, while nevertheless falling within the mammalian range. Additionally, female reproductive skew is higher in polygynous human populations than in polygynous nonhumans mammals on average. This patterning of skew can be attributed in part to the prevalence of monogamy in humans compared to the predominance of polygyny in nonhuman mammals, to the limited degree of polygyny in the human societies that practice it, and to the importance of unequally held rival resources to women's fitness. The muted reproductive inequality observed in humans appears to be linked to several unusual characteristics of our species-including high levels of cooperation among males, high dependence on unequally held rival resources, complementarities between maternal and paternal investment, as well as social and legal institutions that enforce monogamous norms.

Sex ratios and union formation in the historical population of the St. Lawrence Valley.

The ratio of men and women in the adult population, i.e. sex ratio, has long been recognized as a key demographic constraint for partnering behavior. However, the literature remains contradictory on how sex ratio imbalances influence partnering behavior, suggesting either higher or lower rates of male marriage being associated with male-skewed sex ratios. These contradictory findings are likely due to data limitations. Cross-sectional data or limited observation periods preclude studies from distinguishing sex ratio effects on timing from effects on the overall likelihood of marriage. In this paper, we use historical family reconstitution data to study the association of sex ratios with marriage patterns in the French colony of the St. Lawrence Valley in North America (1680-1750). The population experienced a substantial male-skew from sex-selective immigration during the early period of the colony. The long-running observation period allow for differentiating the timing and overall likelihood of marriage. Finally, the data enable us to study the effects of male-skews on the population-level as well as the regional and parish level. Cox proportional hazard models reveal that while male-skewed sex ratios are associated earlier marriage for women, the association with men's marital biographies is less clear-cut. We find that men marry later when sex ratios are more male-skewed, yet we do not find a substantial reduction in the overall likelihood of marriage for men. Our findings reveal that male-skewed sex ratios do not necessarily result in an increase of never married men. We discuss the implications of our findings for the sex ratio literature.

The impact of kin proximity on net marital fertility and maternal survival in Sweden 1900-1910-Evidence for cooperative breeding in a societal context of nuclear families, or just contextual correlations?

OBJECTIVE: We investigate the association between the geographic proximity of the grandparents on net marital fertility and maternal survival in Sweden, 1900-1910, within the framework of the cooperative-breeding-hypothesis. METHODS: Data were derived from Swedish full-count censuses (1880-1910) and the Swedish Death Index. Married couples were linked to their parental households. Poisson and logistic regression analyses were used to investigate the association between the geographical proximity of the grandparents on net marital fertility, which we measured as the number of surviving children born between 1900 and 1910, and the mother's survival. Models were fitted with and without fixed effects to assess the effects of unobserved characteristics shared at the parish and the family level. RESULTS: The results indicate that net fertility and maternal survival increased with the husband's parents' geographic proximity. In contrast, we found no evidence that the geographic proximity of the wife's parents was associated with increased fertility or maternal survival. Rather, the presence of the mother's parents in the household lowered net fertility and reduced maternal survival. CONCLUSIONS: This study provides evidence that kin proximity was associated with fertility and mortality of married women, and that the associations differed for paternal and maternal kin in the societal context of Swedish nuclear families (1900-1910). However, the patterns of kin proximity that we identified were correlated with characteristics such as socioeconomic status, occupation, and wealth, which also exhibited strong correlations with fertility and survival. Future research assessing the effects of kinship on demographic developments must therefore carefully consider the socio-environmental context.

Effects of Individual Mortality Experience on Out-of-Wedlock Fertility in Eighteenth- and Nineteenth-Century Krummhörn, Germany.

Life history theory predicts that exposure to high mortality in early childhood leads to faster and riskier reproductive strategies. Individuals who grew up in a high mortality regime will not overly wait until they find a suitable partner and form a stable union because premature death would prevent them from reproducing. Cox proportional hazard models were used to determine whether women who experienced sibling death during early childhood (0-5 years) reproduced earlier and were at an increased risk of giving birth to an illegitimate child, with illegitimacy serving as a proxy for risky sexual behavior. Furthermore, we investigate whether giving birth out of wedlock is influenced by individual mortality experience or by more promiscuous sexual behavior that is clustered in certain families. Models are fitted on pedigree data from the eighteenth- and nineteenth-century Krummhörn population in Germany. The results show a relationship between sibling death in early childhood and the risk of reproducing out of wedlock, and reproductive timing. The risk of giving birth out of wedlock is linked to individual mortality experience rather than to family-level effects. In contrast, adjustments in connubial reproductive timing are influenced more by family-level effects than by individual mortality experience.

Older fathers' children have lower evolutionary fitness across four centuries and in four populations.

Higher paternal age at offspring conception increases de novo genetic mutations. Based on evolutionary genetic theory we predicted older fathers' children, all else equal, would be less likely to survive and reproduce, i.e. have lower fitness. In sibling control studies, we find support for negative paternal age effects on offspring survival and reproductive success across four large populations with an aggregate N > 1.4 million. Three populations were pre-industrial (1670-1850) Western populations and showed negative paternal age effects on infant survival and offspring reproductive success. In twentieth-century Sweden, we found minuscule paternal age effects on survival, but found negative effects on reproductive success. Effects survived tests for key competing explanations, including maternal age and parental loss, but effects varied widely over different plausible model specifications and some competing explanations such as diminishing paternal investment and epigenetic mutations could not be tested. We can use our findings to aid in predicting the effect increasingly older parents in today's society will have on their children's survival and reproductive success. To the extent that we succeeded in isolating a mutation-driven effect of paternal age, our results can be understood to show that de novo mutations reduce offspring fitness across populations and time periods.

Are stepparents always evil? Parental death, remarriage, and child survival in demographically saturated Krummhörn (1720-1859) and expanding Québec (1670-1750).

Parental death precipitates a cascade of events leading to more or less detrimental exposures, from the sudden and dramatic interruption of parental care to cohabitation with stepparents and siblings in a recomposed family. This article compares the effect of early parental loss on child survival in the past in the Krummhörn region of East Frisia (Germany) and among the French Canadian settlers of the Saint Lawrence Valley (Québec, Canada). The Krummhörn region was characterized by a saturated habitat, while the opportunities for establishing a new family were virtually unlimited for the French Canadian settlers. Early parental loss had quite different consequences in these dissimilar environments. Event history analyses with time-varying specification of family structure are used on a sample of 7,077 boys and 6,906 girls born between 1720 and 1859 in the Krummhörn region and 31,490 boys and 33,109 girls whose parents married between 1670 and 1750 in Québec. Results indicate that in both populations, parental loss is associated with increased infant and child mortality. Maternal loss has a universal and consistent effect for both sexes, while the impact of paternal loss is less easy to establish and interpret. On the other hand, the effect of the remarriage of the surviving spouse is population-specific: the mother's remarriage has no effect in Krummhörn, while it is beneficial in Québec. In contrast, the father's remarriage in Krummhörn dramatically reduces the survival chances of the children born from his former marriage, while such an effect is not seen for Québec. These population-specific effects appear to be driven by the availability of resources and call into question the universality of the "Cinderella" effect.

Phenotype-environment mismatch due to epigenetic inheritance? Programming the offspring's epigenome and the consequences of migration.

OBJECTIVE: It has been suggested that epigenetic inheritance is an important factor influencing mortality. We use data about the historical population of Québec (years 1670-1740) to study whether parents modify their offspring's phenotype epigenetically prior to conception in response to predicted/perceived mortality. If so, children growing up in the predicted environment enjoy a phenotype-environment-match that should lower mortality, whereas children growing up in a nonpredicted environment should have a higher mortality. METHODS: We use the large urban-rural mortality differential to capture the predicted/perceived mortality environment. We categorize children into different groups by their migration status: conceived and living in the same environment (urban or rural); conceived in one but born in another environment (urban-to-rural or rural-to-urban); and born in one but migrating to another environment. We use Kaplan-Meier survival curves and fixed effect survival models to estimate to what extent child survival up to the age of 15 depends on migration status. RESULTS: Child mortality within families that moved from urban to rural areas does not depend on the child's migration status. Within families that moved to urban areas, children who were conceived and born in the rural areas exhibit the lowest mortality. This contradicts a phenotype-environment-mismatch scenario, which would result in higher rather than lower mortality. CONCLUSION: We do not find evidence for functional (adaptive) epigenetic inheritance. Migration into an environment with lower or higher extrinsic mortality affects child mortality within the families differently than predicted by the concept of epigenetic inheritance. The results suggest that epigenetic inheritance may not be important for child mortality among migrants.

Are stepmothers evil or simply unskilled? Infant death clustering in recomposed families.

We measure the concentration of infant deaths in families in the historical populations of Krummhörn, Germany and Québec, Canada in order to investigate whether mothers in recomposed families differ regarding their maternal quality. In particular, we are interested in whether stepmothers in Krummhörn are responsible for a diminution in the survival of their stepchildren because they poorly substitute maternal child care or because they disadvantage their stepchildren. The concentrations of infant deaths within the two populations are measured with Lorenz curves and Gini coefficients, and are compared with expected concentrations given by draws from a binomial distribution. Alleged differences between actual and calculated concentrations represent "causal" death clustering. In the Krummhörn region there is little evidence for "causal" death clustering that would indicate variations regarding their maternal quality, whereas Québec mothers exhibit a distinctively higher concentration of infant deaths.

Short- and long-term consequences of early parental loss in the historical population of the Krummhörn (18th and 19th century).

The impact of the early loss of one's father or one's mother on the survival and age at death of children was investigated on the basis of a historical reconstitution of families from the Krummhörn (East Frisia/Ostfriesland; Germany) with the aid of Kaplan-Meier plots and the Cox regression. In our analyses, we took into account the changed situation of the family after the death of a parent by incorporating the surviving spouse's remarriage or relationships with stepparents. We find that the impact on survival of the children was sex-specific and also depended on whether and at what point in time during childhood their father or mother had died. As expected, children's immediate survival was strongly affected by maternal loss. A few results can be construed as survival diminishing long-term consequences of the early loss of a parent. Daughters who lost their fathers before their first birthday proved to have increased mortality over a longer period of their youth. The age at death of daughters was also lowered if they had to live with a step-mother during early childhood. To interpret these results, three hypotheses, including an (intrinsic) trade-off, compensation and a selection scenario, were tested. Other approaches, which are based, for example, on the extrinsic trade-off between mating effort and parental investment of the surviving parent, also appear to be suitable as an explanation for the long-term consequences, which eventually draws the conclusion that the compensation scenario is the most likely explanation for the consequences of early parental loss.