RESUMO
Isolated primary non-Hodgkin's lymphoma of the frontal sinus is rare. We describe the case of a middle-aged man who came to us with signs of orbital cellulitis complicating an acute infected frontal mucocele. His condition was initially controlled with medical therapy and subsequent endoscopic sinus surgery, but his symptoms eventually returned. We were able to diagnose the lymphoma only by approaching the sinus externally to obtain a biopsy. This case highlights the importance of making a full visual inspection of the involved sinus in order to avoid missing an unexpected, albeit a rarely encountered, pathology.
Assuntos
Seio Frontal , Linfoma de Células B/diagnóstico , Mucocele/complicações , Neoplasias dos Seios Paranasais/diagnóstico , Complicações Pós-Operatórias/diagnóstico , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Celulite (Flegmão)/etiologia , Contraindicações , Endoscopia , Seio Frontal/patologia , Seio Frontal/cirurgia , Humanos , Linfoma de Células B/complicações , Linfoma de Células B/patologia , Linfoma de Células B/terapia , Masculino , Pessoa de Meia-Idade , Mucocele/cirurgia , Neoplasias dos Seios Paranasais/complicações , Neoplasias dos Seios Paranasais/patologia , Neoplasias dos Seios Paranasais/terapia , Reoperação , Tomografia Computadorizada por Raios XRESUMO
We have examined the incidence of Harvey ras mutations in human squamous cell carcinomas (SCC) of the upper aerodigestive tract using the polymerase chain reaction (PCR) followed by direct sequencing. No mutations were detected at codons 12, 13, 59 or 61 of this gene in any of six papillomas, five erythroplakias, 56 squamous cell carcinomas, and 16 SCC cell lines. Some of the SCC were lymph node metastases (three) or tumours which had recurred following radiotherapy (seven). We conclude that Harvey ras mutations are not a common event in the pathogenesis or recurrence of SCCs from Caucasian subjects, in contrast to the situation with Indian populations (Saranath et al., 1991).
Assuntos
Carcinoma de Células Escamosas/genética , Genes ras , Neoplasias de Cabeça e Pescoço/genética , Sequência de Bases , Humanos , Dados de Sequência Molecular , Mutação , Reação em Cadeia da Polimerase , Células Tumorais Cultivadas , População BrancaAssuntos
Ferricianetos , Halotano , Hipotensão Controlada , Metoprolol , Nitroprussiato , Propanolaminas , Adolescente , Adulto , Anestesia Intravenosa , Pressão Sanguínea/efeitos dos fármacos , Esquema de Medicação , Orelha/cirurgia , Eletrocardiografia , Ferricianetos/administração & dosagem , Frequência Cardíaca/efeitos dos fármacos , Humanos , Masculino , Metoprolol/administração & dosagem , Pessoa de Meia-Idade , Nitroprussiato/administração & dosagem , Nariz/cirurgia , Glândula Parótida/cirurgia , Propanolaminas/administração & dosagemRESUMO
A prospective survey of 738 children with high risk factors was carried out in the north-east of Scotland. High risk factors used in previous surveys were reviewed and considered inadequate. New and stringent standards are described. Results are compared with the national incidence of sensori-neural deafness and with other surveys.
