1.
Org Biomol Chem
; 11(4): 549-54, 2013 Jan 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23224077
RESUMO
The electrophilic nature of chalcones (1,3-diphenylprop-2-en-1-ones) and many other α,ß-unsaturated carbonyl compounds is crucial for their biological activity, which is often based on thiol-mediated regulation processes. To better predict their biological activity a simple screening assay for the assessment of the second-order rate constants (k(2)) in thia-Michael additions was developed. Hence, a clear structure-activity relationship of 16 differentially decorated hydroxy-alkoxychalcones upon addition of cysteamine could be established. Moreover, amongst other naturally occurring α,ß-unsaturated carbonyl compounds k(2) values for curcumin and cinnamaldehyde were gained while cinnamic acids or esters gave no or very slow reactions.
Assuntos
Chalconas/química , Compostos de Sulfidrila/química , Cinética
2.
Kinderkrankenschwester
; 22(3): 101-3, 2003 Mar.
Artigo
em Alemão
| MEDLINE
| ID: mdl-15984441
3.
Pflege Z
; 55(11): 824-7, 2002 Nov.
Artigo
em Alemão
| MEDLINE
| ID: mdl-12494698