Assuntos
Anemia/sangue , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Carcinoma de Células Escamosas/tratamento farmacológico , Neoplasias de Cabeça e Pescoço/tratamento farmacológico , Hipóxia/sangue , Anemia/genética , Apoptose/fisiologia , Fatores de Transcrição Hélice-Alça-Hélice Básicos , Carcinoma de Células Escamosas/genética , Carcinoma de Células Escamosas/mortalidade , Intervalo Livre de Doença , Meio Ambiente , Eritropoese/fisiologia , Neoplasias de Cabeça e Pescoço/genética , Neoplasias de Cabeça e Pescoço/mortalidade , Humanos , Concentração de Íons de Hidrogênio , Hipóxia/genética , Subunidade alfa do Fator 1 Induzível por Hipóxia , Oxigênio/sangue , Transdução de Sinais , Transativadores/genética , Fatores de Transcrição/genética , Falha de TratamentoRESUMO
This study was conducted to evaluate quality of life in a cohort of patients with squamous cell carcinoma of the tongue base, treated with primary surgery, reconstruction and postoperative radiotherapy. Twelve patients were assessed in a cross-sectional study using the University of Washington Quality of Life Instrument (UW-QOL). All patients underwent external beam irradiation following primary resection of their tumour and reconstruction. Patients on average reported their overall and health related QOL to be good. Functionally they had good pain control, speech intelligibility, activity and recreational levels. There were some limitations in chewing, swallowing and taste. The results suggest that surgical resection can offer good functional and overall QOL results for advanced tumours when combined with reconstruction. The morbidity associated with postoperative radiotherapy includes reduced swallowing, taste, saliva production and difficulty chewing.
Assuntos
Braquiterapia , Carcinoma de Células Escamosas/psicologia , Qualidade de Vida , Neoplasias da Língua/psicologia , Língua/cirurgia , Adulto , Idoso , Braquiterapia/efeitos adversos , Braquiterapia/métodos , Braquiterapia/psicologia , Carcinoma de Células Escamosas/radioterapia , Carcinoma de Células Escamosas/cirurgia , Estudos de Coortes , Intervalo Livre de Doença , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Procedimentos de Cirurgia Plástica/psicologia , Retalhos Cirúrgicos , Inquéritos e Questionários , Neoplasias da Língua/radioterapia , Neoplasias da Língua/cirurgiaAssuntos
Vértebras Cervicais/lesões , Fraturas da Coluna Vertebral/diagnóstico , Acidentes de Trânsito , Vértebras Cervicais/diagnóstico por imagem , Vértebras Cervicais/cirurgia , Eletromiografia/métodos , Feminino , Humanos , Recém-Nascido , Equipamentos de Proteção , Fraturas da Coluna Vertebral/diagnóstico por imagem , Fraturas da Coluna Vertebral/cirurgia , Tomografia Computadorizada por Raios X/métodos , Resultado do TratamentoRESUMO
Hypohidrotic ectodermal dysplasia (HED) is a rare condition characterized by abnormalities to ectodermal derived tissues although other organs or systems are frequently involved. Patients with HED can have a number of symptoms that may lead them to present to the otolaryngologist. We present a case of a 37-year-old female with HED who initially presented with nasal obstruction but then very rapidly developed stridor due to a tracheal squamous cell carcinoma. We suggest a possible association between HED and carcinoma of the upper respiratory tract that has not previously been reported.
Assuntos
Carcinoma de Células Escamosas/complicações , Displasia Ectodérmica/complicações , Hipo-Hidrose/complicações , Neoplasias da Traqueia/complicações , Adulto , Feminino , Glote , Humanos , Laringoestenose/etiologia , Imageamento por Ressonância Magnética/métodosRESUMO
There are no published guidelines for the sterilization of the flexible nasendoscope and various techniques exist. We have conducted a randomized, prospective, blinded trial of the barrier Endosheath system versus immersion in Cidex disinfectant. Using a visual analogue assessment, there were no differences at a 99% confidence interval (CI) between the two techniques from the nursing assistant and patient perspectives. Image quality was assessed blinded and no difference could be detected at a 99% CI. The Endosheath offers the advantage of increasing the productivity of each nasendoscope as the sterilization time is reduced. It also provides barrier protection against cross-contamination, including prion diseases.