RESUMO
The validity and reliability of a scoring system for 'neurological soft signs' in teenagers was assessed. Six scales were adapted and fitted into the framework of a conventional neurological examination. The following emerged: each of the three multi-item scales had high internal consistency; inter-rater agreement on mirror movements of 'live' subjects was satisfactory; ratings of videotapes agreed among examiners for mirror movements and dysdiadochokinesis but not for choreiform movements; data-based cut-off scores defining present vs. absent were congruent with the ratings of outside neurologists; and each examiner was consistent in rating mirror movements and rapid alternating movements from videotapes over several months.
Assuntos
Doenças do Sistema Nervoso/diagnóstico , Exame Neurológico , Adolescente , Criança , Humanos , Masculino , Transtornos dos Movimentos/diagnóstico , Exame Neurológico/métodos , Exame Neurológico/normas , Gravação de VideoteipeRESUMO
We report a case of atypical subacute sclerosing panencephalitis (SSPE) in which the diagnosis was confirmed by a new radioimmunoprecipitation method. Antimeasles antibody was absent in the cerebrospinal fluid (CSF) when measured by conventional immunoassay techniques, there was no clinical response to isoprinosine, and the patient showed a selective absence of CSF antibody response to the matrix protein and only a partial serum antibody response to this measles polypeptide. The value of this sensitive immunoprecipitation method in profiling the selective antibody responses to the several measles polypeptides and the advisability of using isoprinosine, an immunopotentiating agent, to treat SSPE are discussed.
