1.
Org Biomol Chem
; 21(22): 4591-4595, 2023 Jun 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37203457
RESUMO
Fragment-based lead discovery (FBLD) often relies on flat, aromatic compounds which display undesirable physicochemical properties with limited exit vectors for fragment growth. Herein, we report concise synthetic strategies to sp3-rich heterocyclic fragments encompassing polar exit vectors poised for fragment-to-lead (F2L) development.