Assuntos
Aterosclerose , Medicamentos de Ervas Chinesas , Hiperlipidemias , Hipertensão , Pueraria , Salvia miltiorrhiza , Anlodipino , Aterosclerose/tratamento farmacológico , Atorvastatina , Humanos , Hidroclorotiazida , Hiperlipidemias/tratamento farmacológico , Hipertensão/tratamento farmacológicoRESUMO
MK-7246, an antagonist of the chemoattractant receptor on T helper type 2 (Th2) cells, is being developed for the treatment of respiratory diseases. In a first-in-human study, we investigated whether genetic polymorphisms contributed to the marked intersubject variability in the pharmacokinetics of MK-7246 and its glucuronide metabolite M3. Results from in vitro enzyme kinetic studies suggested that UGT2B17 is probably the major enzyme responsible for MK-7246 metabolism in both the liver and the intestine. As compared with those with the UGT2B17*1/*1 wild-type genotype, UGT2B17*2/*2 carriers, who possess no UGT2B17 protein, had 25- and 82-fold greater mean dose-normalized values of area under the plasma concentration-time curve (AUC) and peak concentration of MK-7246, respectively, and a 24-fold lower M3-to-MK-7246 AUC ratio. The apparent half-life of MK-7246 was not as variable between these two genotypes. Therefore, the highly variable pharmacokinetics of MK-7246 is attributable primarily to the impact of UGT2B17 genetic polymorphisms and extensive first-pass metabolism of MK-7246.
Assuntos
Carbolinas/farmacocinética , Glucuronosiltransferase/genética , Administração Oral , Adulto , Área Sob a Curva , Método Duplo-Cego , Monitoramento de Medicamentos , Genótipo , Glucuronídeos/metabolismo , Meia-Vida , Humanos , Masculino , Antígenos de Histocompatibilidade Menor , Farmacogenética/métodos , Polimorfismo Genético , Receptores de Antígenos de Linfócitos T/antagonistas & inibidoresRESUMO
The authors designed 2 randomized controlled studies to examine the effects of etoricoxib 60 to 120 mg daily on methotrexate pharmacokinetics in 50 rheumatoid arthritis (RA) patients on stable doses of methotrexate (7.5-20 mg). Patients received oral methotrexate at baseline and on days 7 and 14. In study 1, patients received etoricoxib 60 mg (days 1-7) and then 120 mg (days 8-14); in study 2, patients received etoricoxib 90 mg (days 1-7) and then 120 mg (days 8-14). For study 1, the AUC(0-infinity) geometric mean ratio (GMR) (90% confidence interval [CI]) for day 7 versus baseline was 1.01 (0.91, 1.12) for etoricoxib 60 mg; the area under the plasma concentration-time curve from zero to infinity (AUC(0-infinity)) GMR (90% CI) for day 14 was 1.28 (1.15, 1.42) for etoricoxib 120 mg. For study 2, the AUC(0-infinity) GMR (90% CI) for day 7 versus baseline was 1.07 (1.01, 1.13) for etoricoxib 90 mg; the AUC(0-infinity) GMR (90% CI) for day 14 was 1.05 (0.99, 1.11) for etoricoxib 120 mg. In summary, etoricoxib 60 and 90 mg had no effect on methotrexate plasma concentrations. Although no effect on methotrexate pharmacokinetics was observed with etoricoxib 120 mg in study 2, GMR AUC(0-infinity) fell outside the prespecified bounds in study 1. Standard monitoring of methotrexate-related toxicity should be continued when etoricoxib and methotrexate are administered concurrently, especially with doses >90 mg etoricoxib.
Assuntos
Antirreumáticos/farmacocinética , Inibidores de Ciclo-Oxigenase 2/efeitos adversos , Quimioterapia Combinada/efeitos adversos , Metotrexato/farmacocinética , Piridinas/efeitos adversos , Sulfonas/efeitos adversos , Administração Oral , Adulto , Idoso , Antirreumáticos/administração & dosagem , Artrite Reumatoide/tratamento farmacológico , Inibidores de Ciclo-Oxigenase 2/administração & dosagem , Relação Dose-Resposta a Droga , Esquema de Medicação , Interações Medicamentosas , Etoricoxib , Feminino , Humanos , Masculino , Metotrexato/administração & dosagem , Pessoa de Meia-Idade , Piridinas/administração & dosagem , Sulfonas/administração & dosagemRESUMO
In this study, the 27 kDa immunodominant antigen (CP23), 70 kDa heat shock protein (HSP70), actin and beta-tubulin genes were amplified and sequenced for the first time from human isolates of Cryptosporidium cervine genotype. New primers were designed from reported sequences of other Cryptosporidium species and genotypes as well as the whole genome sequences of C. parvum and C. hominis, which enabled novel gene sequences and regions extending beyond those deposited in GenBank to be determined. In comparison with other species in the Cryptosporidium genus, multiple sequence alignment and phylogenetic analysis revealed that the Cryptosporidium cervine genotype isolates from humans clustered most closely with Cryptosporidium deer mouse genotype and C. suis (n. sp. formerly pig genotype I). The complete coding sequence of CP23 was determined to reveal low (72.4% and 68.0-69.8% respectively) identity to C. parvum and C. hominis sequences and the presence of a unique multiple proline-alanine-proline-valine (PAPV) repeat region.
Assuntos
Cryptosporidium/classificação , Cryptosporidium/genética , Cervos/parasitologia , Actinas/química , Actinas/genética , Actinas/metabolismo , Sequência de Aminoácidos , Animais , Antígenos de Protozoários/química , Antígenos de Protozoários/genética , Antígenos de Protozoários/metabolismo , Primers do DNA , Genótipo , Proteínas de Choque Térmico HSP72/química , Proteínas de Choque Térmico HSP72/genética , Proteínas de Choque Térmico HSP72/metabolismo , Humanos , Epitopos Imunodominantes/química , Epitopos Imunodominantes/genética , Epitopos Imunodominantes/metabolismo , Dados de Sequência Molecular , Filogenia , Análise de Sequência de DNA , Tubulina (Proteína)/química , Tubulina (Proteína)/genética , Tubulina (Proteína)/metabolismoRESUMO
Rofecoxib is a highly selective and potent inhibitor of cyclooxgenase-2 (COX-2). Methotrexate is a disease-modifying agent with a narrow therapeutic index frequently prescribed for the management of rheumatoid arthritis. The objective of this study was to investigate the influence of clinical doses of rofecoxib on the pharmacokinetics of methotrexate in patients with rheumatoid arthritis. This was a randomized, double-blind, placebo-controlled study in 25 rheumatoid arthritis patients on stable doses of methotrexate. Patients received oral methotrexate (7.5 to 20 mg) on days -1, 7, 14, and 21. Nineteen patients received rofecoxib 12.5, 25, and 50 mg once daily on days 1 to 7, 8 to 14, and 15 to 21, respectively. Six patients received placebo on days 1 to 21 only to maintain a double-blinded design for assessment of adverse experiences. Plasma and urine samples were analyzed for methotrexate and its major although inactive metabolite, 7-hydroxymethotrexate. The AUC(0-infinity) geometric mean ratios (GMR) and their 90% confidence intervals (90% CI) (rofecoxib + methotrexate/methotrexate alone) for day 7/day -1, day 14/day -1, and day 21/day -1, for rofecoxib 12.5, 25, and 50 mg, were 1.03 (0.93, 1.14), 1.02 (0.92, 1.12), and 1.06 (0.96, 1.17), respectively (p > 0.2 for all comparisons to day -1). All AUC(0-infinity), GMR and Cmax GMR 90% CIs fell within the predefined comparability limits of (0.80, 1.25). Similar results were observed for renal clearance of methotrexate and 7-hydroxymethotrexate at the highest dose of rofecoxib tested (50 mg). It was concluded that rofecoxib at doses of 12.5, 25, and 50 mg once daily has no effect on the plasma concentrations or renal clearance (tested at the highest dose of rofecoxib) of methotrexate in rheumatoid arthritis patients.
Assuntos
Antirreumáticos/sangue , Artrite Reumatoide/sangue , Inibidores de Ciclo-Oxigenase/farmacocinética , Lactonas/farmacocinética , Metotrexato/análogos & derivados , Metotrexato/sangue , Adulto , Idoso , Análise de Variância , Área Sob a Curva , Intervalos de Confiança , Inibidores de Ciclo-Oxigenase/administração & dosagem , Relação Dose-Resposta a Droga , Método Duplo-Cego , Interações Medicamentosas/fisiologia , Feminino , Antagonistas do Ácido Fólico/sangue , Humanos , Lactonas/administração & dosagem , Masculino , Pessoa de Meia-Idade , SulfonasRESUMO
Potential for inhibition of CYP3A activity by simvastatin, an HMG-CoA reductase inhibitor, was evaluated in 12 healthy male subjects who received placebo or 80 mg of simvastatin, the maximal recommended dose, once daily for 7 consecutive days. On day 7, an intravenous injection of 3 microCi [14C N-methyl]erythromycin for the erythromycin breath test (EBT) was coadministered with a 2 mg oral solution of midazolam. The values for percent 14C exhaled during the first hour (for EBT) and the pharmacokinetic parameters of midazolam (AUC, Cmax, t1/2) were not affected following multiple once-daily oral doses of simvastatin 80 mg. The 95% confidence interval was 0.97 to 1.18 for EBT and 0.99 to 1.23 for midazolam AUC. In addition, the total urinary recoveries of midazolam and its 1'-hydroxy metabolites (free plus conjugate) obtained from both treatments were not statistically different (p > 0.200). These data demonstrate that multiple dosing of simvastatin, at the highest recommended clinical dose, does not significantly alter the in vivo hepatic or intestinal CYP3A4/5 activity as measured by the commonly used EBT and oral midazolam probes.
Assuntos
Hidrocarboneto de Aril Hidroxilases , Inibidores das Enzimas do Citocromo P-450 , Eritromicina/farmacocinética , Inibidores de Hidroximetilglutaril-CoA Redutases/farmacologia , Midazolam/farmacocinética , Oxirredutases N-Desmetilantes/antagonistas & inibidores , Sinvastatina/farmacologia , Administração Oral , Adulto , Testes Respiratórios , Estudos Cross-Over , Citocromo P-450 CYP3A , Humanos , Masculino , Método Simples-CegoRESUMO
Steady-state inhibitory activity of rofecoxib (Vioxx) on COX-2 versus COX-1 was compared with that of commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) in 76 healthy volunteers randomized to placebo, rofecoxib 12.5 mg qd, rofecoxib 25 mg qd, diclofenac 50 mg tid, ibuprofen 800 mg tid, sodium naproxen 550 mg bid, or meloxicam 15 mg qd. All of these doses include the high end of the approved clinical dose range. Ex vivo whole-blood assays were used to determine the effect on COX-2 and COX-1 activity, respectively. Urinary prostanoids were also measured. Mean inhibition of COX-2 (measured as the weighted average inhibition [WAI] of lipopolysaccharide [LPS]-induced PGE2 generation over 8 hours on day 6 vs. baseline) was -2.4%, 66.7%, 69.2%, 77.5%, 93.9%, 71.4%, and 71.5% for placebo, rofecoxib 12.5 mg, rofecoxib 25 mg, meloxicam, diclofenac, ibuprofen, and naproxen, respectively. Corresponding values for mean inhibition of COX-1 (measured as TXB2 generation in clotting whole blood) were -5.15%, 7.98%, 6.65%, 53.3%, 49.5%, 88.7%, and 94.9%. Rofecoxib had no significant effect on urinary excretion of 11-dehydro TXB2, a COX-1-derived product. These data support the contention that rofecoxib is the only drug of the regimens tested that uniquely inhibits COX-2 without affecting COX-1.
Assuntos
Inibidores de Ciclo-Oxigenase/farmacologia , Isoenzimas/antagonistas & inibidores , Adolescente , Adulto , Tempo de Sangramento , Ciclo-Oxigenase 1 , Ciclo-Oxigenase 2 , Inibidores de Ciclo-Oxigenase 2 , Inibidores de Ciclo-Oxigenase/efeitos adversos , Diclofenaco/efeitos adversos , Diclofenaco/farmacologia , Dinoprostona/metabolismo , Feminino , Humanos , Ibuprofeno/efeitos adversos , Ibuprofeno/farmacologia , Isoenzimas/metabolismo , Lactonas/efeitos adversos , Lactonas/farmacologia , Lipopolissacarídeos/farmacologia , Meloxicam , Proteínas de Membrana , Pessoa de Meia-Idade , Naproxeno/efeitos adversos , Naproxeno/farmacologia , Agregação Plaquetária/efeitos dos fármacos , Prostaglandina-Endoperóxido Sintases/metabolismo , Prostaglandinas/urina , Sulfonas , Tiazinas/efeitos adversos , Tiazinas/farmacologia , Tiazóis/efeitos adversos , Tiazóis/farmacologia , Tromboxano B2/sangueRESUMO
Montelukast, a cysteinyl leukotriene receptor antagonist, is being developed for the treatment of asthma and related diseases. This study was designed to evaluate whether montelukast at clinically used dosage levels would interfere with the anticoagulant effect of warfarin. In a two-period, double-blind, randomized crossover study, 12 healthy male subjects received a single oral dose of 30 mg warfarin on the 7th day of a 12-day treatment with montelukast, 10 mg daily by mouth, or a placebo. Montelukast had no significant effect on the area under the plasma concentration-time curves and peak plasma concentrations of either R- or S-warfarin. However, slight but statistically significant decreases in time to peak concentration of both warfarin enantiomers and in elimination half-life of the less potent R-warfarin were observed in the presence of montelukast. These changes were not considered as clinically relevant. Montelukast had no significant effect on the anticoagulant effect of warfarin, as assessed by the international normalized ratio (INR) for prothrombin time (AUC0-144 and INR maximum). The results of this study suggest that a clinically important interaction between these drugs is unlikely to occur in patients requiring concomitant administration of both drugs.
Assuntos
Acetatos/farmacologia , Antiasmáticos/farmacologia , Anticoagulantes/farmacologia , Anticoagulantes/farmacocinética , Antagonistas de Leucotrienos/farmacologia , Quinolinas/farmacologia , Varfarina/farmacologia , Varfarina/farmacocinética , Adulto , Área Sob a Curva , Estudos Cross-Over , Ciclopropanos , Método Duplo-Cego , Interações Medicamentosas , Humanos , Coeficiente Internacional Normatizado , Masculino , Tempo de Protrombina , SulfetosRESUMO
Two patients undergoing stent placement with the Palmaz-Schatz coronary stent delivery system experienced intracoronary stent embolization. Using a two-wire technique, the stents were successfully removed from the coronary circulation, and this allowed completion of the percutaneous revascularization procedure without any clinical sequelae. These two cases represent the first report of successful percutaneous retrieval of undeployed, retained intracoronary Palmaz-Schatz stents.
Assuntos
Doença das Coronárias/terapia , Vasos Coronários , Stents , Cateterismo Cardíaco/métodos , Constrição Patológica/diagnóstico por imagem , Constrição Patológica/terapia , Angiografia Coronária , Doença das Coronárias/diagnóstico por imagem , Falha de Equipamento , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
The standard Palmaz-Schatz coronary stent delivery system (SDS), with a 15 mm articulated stent and a 5F protective sheath, is relatively rigid and high in profile. Its use is contraindicated in vessels where there is severe tortuosity proximal to or in the lesion itself. Recently a new SDS, with a short (8 mm) nonarticulated stent, has become available. We present three patients with complex coronary anatomy solved with this new SDS. The first patient had a distal stenosis in an extremely tortuous and diffusely diseased right coronary artery (RCA). The second patient had a severe proximal RCA stenosis occurring at a bend of more than 90 degrees. The third patient had a very long stenosis of the left anterior descending coronary artery involving the ostium, requiring multiple tandem stenting. The availability of this short stent will greatly expand the clinical application of intracoronary stenting to patients with complex coronary anatomy.
Assuntos
Angioplastia com Balão/instrumentação , Doença das Coronárias/terapia , Stents , Idoso , Angioplastia com Balão/métodos , Angiografia Coronária , Doença das Coronárias/diagnóstico , Desenho de Equipamento , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
Stent implantation into an infarct-related artery during acute myocardial infarction is generally contraindicated because of the risk of stent thrombosis. We report on 3 patients who had successful stenting for an acute occlusive dissection that developed during direct infarct coronary angioplasty and was refractory to conventional prolonged balloon dilatation, with good long-term clinical and angiographic results. The prerequisites for success include proper premedication, presence of only a minimal amount of thrombus in the infarct-related artery, liberal use of intracoronary thrombolytic therapy, as perfect an angiographic result as possible, as well as careful and aggressive post-stenting anticoagulation.
Assuntos
Vasos Coronários , Infarto do Miocárdio/terapia , Stents , Angioplastia Coronária com Balão/efeitos adversos , Doença das Coronárias/etiologia , Doença das Coronárias/prevenção & controle , Vasos Coronários/lesões , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/etiologia , Stents/efeitos adversos , Terapia Trombolítica , Trombose/etiologia , Trombose/prevenção & controleRESUMO
Between January 1991 and December 1992, 136 Palmaz-Schatz coronary stents were implanted in 113 native coronary arteries in 106 patients. Forty-seven patients presented with stable angina, 50 with unstable angina, 7 with congestive cardiac failure and unstable angina and 2 were asymptomatic. Stenting was carried out in 15 patients for restenosis after coronary angioplasty (PTCA), 32 for significant dissection during PTCA (with 19 acute and 13 threatened closure), 10 for suboptimal PTCA results and 56 for de novo lesions, 52 (92.9%) of which were either ACC/AHA type B or C. Successful delivery was achieved in 97.2% (103/106) of patients or 97.3% (110/113) of vessels. Percent diameter stenosis was reduced from 78 +/- 13% to 4 +/- 11%. There were two subacute stent thromboses (1.9%), resulting in Q-Wave myocardial infarction. Three deaths (2.9%) occurred, all from the group with congestive cardiac failure and unstable angina. Major bleeding/vascular complications occurred in 4 patients (3.9%). All patients were followed up for a mean of 18 months (6 months to 30 months). Eighty-five patients were asymptomatic. Three patients were angina-free but continued to have, albeit improved, congestive cardiac failure. Ten patients had recurrence of angina, all within 6 months of the stenting procedure. Four were treated medically and 4 had PTCA of whom one eventually had coronary bypass surgery. Two patients had new lesions, successfully treated by PTCA or stenting. In conclusion, a high rate of successful delivery of the Palmaz-Schatz coronary stent can be achieved in a wide spectrum of patients with few complications which are mostly related to anticoagulation. It offers very effective bailout for acute closure during PTCA. Despite the presence of unfavorable pre-procedure patient and lesion characteristics, the acute and long term clinical results are encouraging.
Assuntos
Isquemia Miocárdica/terapia , Stents , Adulto , Idoso , Idoso de 80 Anos ou mais , Angioplastia Coronária com Balão/efeitos adversos , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Stents/efeitos adversos , Resultado do TratamentoRESUMO
Scrap metal cutters seemed to be left out in most preventive programmes as the workers were mainly contract workers. The health hazards of scrap metal cutting in 54 workers from a foundry and a ship breaking plant were evaluated. Environmental sampling showed lead levels ranging from 0.02 to 0.57 mg/m3 (threshold limit values is 0.15 mg/m3). Exposure to lead came mainly from the paint coat of the metals cut. Metal fume fever was not reported although their main complaints were cough and rhinitis. Skin burns at all stages of healing and residual scars were seen over hands, forearms and thighs. 96% of the cutters had blood lead levels exceeding 40 micrograms/100 ml with 10 workers exceeding 70 micrograms/100 ml. None had clinical evidence of lead poisoning. The study showed that scrap metal cutting is a hazardous industry associated with significant lead exposure. With proper medical supervision, the blood lead levels of this group of workers decreased illustrating the importance of identifying the hazard and implementing appropriate medical surveillance programmes.
Assuntos
Metais/intoxicação , Doenças Profissionais/diagnóstico , Adulto , Intoxicação por Arsênico , Intoxicação por Cádmio/diagnóstico , Intoxicação por Cádmio/epidemiologia , Exposição Ambiental , Humanos , Chumbo/sangue , Masculino , Doenças Profissionais/epidemiologia , Doenças Profissionais/prevenção & controleRESUMO
A patient with recurrent meningitis over five and a half years due to Cryptococcus neoformans is reported. The relapsing course and the unusual diagnostic features are emphasized.
Assuntos
Criptococose/diagnóstico , Meningite/etiologia , Adulto , Doença Crônica , Cryptococcus neoformans/isolamento & purificação , Diagnóstico Diferencial , Humanos , Masculino , Meningite/diagnóstico , Meningite Viral/diagnóstico , Recidiva , Punção Espinal , Fatores de TempoRESUMO
This is a study on atmospheric concentration of total chromium and hexavalent chromate and its role in chromate sensitivity. Air concentration of total chromium and hexavalent chromate in a construction factory, a busy city area, a suburban area, a residential area, and a heavy industrial area were measured by air sampling pumps. Hexavalent chromate was not detected in any sampled areas. Two (concreting areas) of 8 locations in the construction factory had total chromium of 0.2 and 2.3 micrograms/m3 in the atmosphere. It appeared that the atmospheric concentration of total chromium and hexavalent chromate was negligible. These findings indicate that unexplained chromate sensitivity, as so often seen in patients attending a contact dermatitis clinic, is not attributable to exposure to hexavalent chromate in the air.
Assuntos
Cromatos/efeitos adversos , Materiais de Construção/efeitos adversos , Dermatite de Contato/etiologia , Dermatite Ocupacional/induzido quimicamente , Poeira/efeitos adversos , Humanos , Risco , SingapuraRESUMO
The involvement of Ca++ ions as secretory mediators in pig jejunal epithelia has been investigated with an in vitro system. Omission of Ca++ from the Ringer-HCO3 bathing media on both sides of the tissue had minor effects on the basal electrical activity of pig jejunal mucosa. There were only slight decreases in transepithelial potential difference and increases in conductance with Ca++ free media. Low EGTA concentrations which reversibly blocked potential difference responses to secretory agents also had minimal effects on basal electrical activity. The in vitro secretory responses to A23187, to theophylline, and to Escherichia coli heat-stable enterotoxin were all eliminated by Ca++ depletion and restored by replacing normal Ca++ concentrations in the bathing media. Dantrolene prevented the secretory response but not the potential difference increases caused by heat-stable enterotoxin and A23187, suggesting that intracellular Ca++ stores may be reservoirs of secretory signal agent. Verapamil only blocked the secretory response to heat-stable enterotoxin. Chlorpromazine had negligible effects on basal conditions, but totally blocked both the secretory response and the Ca++-dependent effects of A23187 and heat-stable enterotoxin on potential difference. The response to theophylline was only partially inhibited by chlorpromazine, implying some involvement of both cAMP and Ca++ as secretory signals for theophylline. Cytoplasmic Ca++ concentrations appear to be at least as important as cyclic nucleotides in regulating the secretory effects of pig jejunum.
Assuntos
Toxinas Bacterianas , Cálcio/farmacologia , Mucosa Intestinal/efeitos dos fármacos , Suínos/metabolismo , Animais , Calcimicina/farmacologia , Permeabilidade da Membrana Celular/efeitos dos fármacos , Clorpromazina/farmacologia , Dantroleno/farmacologia , Ácido Egtázico/farmacologia , Enterotoxinas/farmacologia , Proteínas de Escherichia coli , Mucosa Intestinal/metabolismo , Mucosa Intestinal/fisiologia , Canais Iônicos/metabolismo , Jejuno , Potenciais da Membrana/efeitos dos fármacos , Teofilina/farmacologia , Verapamil/farmacologiaRESUMO
We report our experience with the use of a USCI Sones catheter curve A type 1 (7540) to cross the aortic valves of 45 patients with clinically significant aortic stenosis. The technique was successful in all our patients with a fluoroscopic time of less than 3 min. A gradient of up to 200 mmHg across the aortic valve area was recorded, and the smallest valve area calculated was less than 0.2 cm2. The method obviated the need for a guidewire and satisfactory left ventriculograms were obtained. No major complication was observed. We conclude that the technique is a simple, rapid, and safe means of obtaining left ventricular hemodynamic and angiographic information in patients with aortic stenosis of various degrees of severity.
Assuntos
Estenose da Valva Aórtica/diagnóstico , Cateterismo Cardíaco/métodos , Adulto , Idoso , Angiografia , Estenose da Valva Aórtica/diagnóstico por imagem , Cateterismo Cardíaco/instrumentação , Angiografia Coronária , Feminino , Fluoroscopia , Ventrículos do Coração/diagnóstico por imagem , Hemodinâmica , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
Familial prevalence of mitral valve prolapse in a Chinese population was determined in 22 propositi of whom 10 had straight back (group A), three had abnormally high metacarpal index (group B), and nine had neither (group C). Of 71 (32 male and 39 female subjects) first degree relatives screened, mitral valve prolapse was found in 19 (seven male and 12 female subjects) (26.8%). The familial prevalence among groups A, B, and C was 20%, 30%, and 38.5%, respectively. Our study indicates that the familial occurrence of mitral valve prolapse does not depend on its association with the straight back syndrome.