1.
J Org Chem
; 72(10): 3969-71, 2007 May 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17444687
RESUMO
A facile and general protocol for the preparation of isothiocyanates from alkyl and aryl amines is reported. This method relies on a tosyl chloride mediated decomposition of a dithiocarbamate salt that is generated in situ by treatment of an amine with carbon disulfide and triethylamine. Utilizing this protocol, we have prepared 19-alkyl- and arylisothiocyanates in moderate to excellent yield.