1.
Arch Immunol Ther Exp (Warsz)
; 40(3-4): 207-12, 1992.
Artigo
em Inglês
| MEDLINE
| ID: mdl-1300985
RESUMO
We investigated the influence of tuftsin partial sequences (Thr-Lys, Lys-Pro, Lys-Pro-Arg and Pro-Arg) on histamine concentration in selected tissues (lungs, kidneys, liver, duodenal wall and arterial blood) of guinea-pigs and rats. The peptides were administered in 1 mg/kg dose intravenously (single dose) or intraperitoneally (single dose or three doses at one-hour intervals). Histamine concentration was determined spectrofluorimetrically. Tissues used in the determination were taken 1 hour after the last injection. It was found that Pro-Arg and Lys-Pro-Arg (similarly to tuftsin), lower histamine concentration in lungs, and elevate it in kidneys.