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1.
Micromachines (Basel) ; 15(2)2024 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-38398936

RESUMO

In recent years, the development of terahertz (THz) technology has attracted significant attention. Various tunable devices for THz waves (0.1 THz-10 THz) have been proposed, including devices that modulate the amplitude, polarization, phase, and absorption. Traditional metal materials are often faced with the problem of non-adjustment, so the designed terahertz devices play a single role and do not have multiple uses, which greatly limits their development. As an excellent phase change material, VO2's properties can be transformed by external temperature stimulation, which provides new inspiration for the development of terahertz devices. To address these issues, this study innovatively combines metamaterials with phase change materials, leveraging their design flexibility and temperature-induced phase transition characteristics. We have designed a THz intelligent absorber that not only enables flexible switching between multiple functionalities but also achieves precise performance tuning through temperature stimulation. Furthermore, we have taken into consideration factors such as the polarization mode, environmental temperature, structural parameters, and incident angle, ensuring the device's process tolerance and environmental adaptability. Additionally, by exploiting the principle of localized surface plasmon resonance (LSPR) accompanied by local field enhancement, we have monitored and analyzed the resonant process through electric field characterization. In summary, the innovative approach and superior performance of this structure provide broader insights and methods for THz device design, contributing to its theoretical research value. Moreover, the proposed absorber holds potential for practical applications in electromagnetic invisibility, shielding, modulation, and detection scenarios.

2.
Materials (Basel) ; 16(22)2023 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-38005137

RESUMO

We propose a novel micro-nano structure that can realize a photonic nanojet (PNJ) switch by adjusting the temperature, which is composed of a truncated cylinder coated with a thin vanadium dioxide (VO2) film. The influence of temperature on the maximum strength, full width at half maximum (FWHM), working distance, and focal length of the PNJ were studied by finite-difference time-domain (FDTD) method. The results demonstrate that the structure can adjust the open and close state of the PNJ by changing the temperature. A PNJ with varying characteristics can be obtained at both high and low temperatures, and the maximum intensity ratio of the PNJ can reach up to 7.25. This discovery provides a new way of optical manipulation, sensing and detection, microscopy imaging, optoelectronic devices, and other fields.

3.
Opt Express ; 31(21): 34503-34513, 2023 Oct 09.
Artigo em Inglês | MEDLINE | ID: mdl-37859205

RESUMO

We report an approach to simultaneously control orbital angular momentum (OAM) orientation and topological charge in highly localized optical vortices by employing a 4π focusing system. The required continuous wave illumination field in the pupil planes is derived by superimposing the radiation pattern of only one dipole placed at the focal point of the high numerical aperture lens and the corresponding tailored spiral phase factor. The topological charge and OAM orientation of the obtained focused fields are quantitatively evaluated based on the focal field distributions calculated by the Richards-Wolf vector diffraction integration theory. Results show that the OAM of the generated optical vortices can be tailored by changing the oscillation orientation of the mimic dipole and the topological charge of the superimposed spiral phase term. The presented method may find potential applications in optical trapping, optical tweezers, light-matter interaction, etc.

4.
Sensors (Basel) ; 23(17)2023 Aug 31.
Artigo em Inglês | MEDLINE | ID: mdl-37688037

RESUMO

Here, we document a D-type double open-loop channel floor plasmon resonance (SPR) photonic crystal fiber (PCF) for temperature sensing. The grooves are designed on the polished surfaces of the pinnacle and backside of the PCF and covered with a gold (Au) film, and stomata are distributed around the PCF core in a progressive, periodic arrangement. Two air holes between the Au membrane and the PCF core are designed to shape a leakage window, which no longer solely averts the outward diffusion of Y-polarized (Y-POL) core mode energy, but also sets off its coupling with the Au movie from the leakage window. This SPR-PCF sensor uses the temperature-sensitive property of Polydimethylsiloxane (PDMS) to reap the motive of temperature sensing. Our lookup effects point out that these SPR-PCF sensors have a temperature sensitivity of up to 3757 pm/°C when the temperature varies from 5 °C to 45 °C. In addition, the maximum refractive index sensitivity (RIS) of the SPR-PCF sensor is as excessive as 4847 nm/RIU. These proposed SPR-PCF temperature sensors have an easy nanostructure and proper sensing performance, which now not solely improve the overall sensing performance of small-diameter fiber optic temperature sensors, but also have vast application prospects in geo-logical exploration, biological monitoring, and meteorological prediction due to their remarkable RIS and exclusive nanostructure.

5.
Phys Chem Chem Phys ; 25(30): 20706-20714, 2023 Aug 02.
Artigo em Inglês | MEDLINE | ID: mdl-37489769

RESUMO

In this work, we theoretically designed a dynamically changeable terahertz metamaterial absorber with intelligent switch and high sensitivity, wide band and narrow band perfect absorption based on the combination of Dirac semimetal (BDS) and vanadium dioxide (VO2). It features two methods for absorption adjustment: altering the Fermi energy level of BDS to modify the resonant frequency of the absorption peaks and utilizing the phase change of VO2 to regulate the absorption rate of the peaks. In addition, its rotational symmetric design ensures strong polarization-insensitivity. The simulation results demonstrate the presence of two narrowband absorption peaks and one mini-broadband absorption peak within the frequency range of 6.0-9.5 THz, all with absorption rates exceeding 90%. We provide an explanation of the absorption mechanism of the device, employing the relative impedance theory and localized surface plasmon resonance to analyze its electric field distribution. We also defined the refractive index sensitivity (S), which is SI = 378 GHz per RIU and SIII = 204 GHz per RIU. Our device possesses high sensitivity and two methods of adjusting absorption modes, which endow it with advantages in the fields of metamaterial absorbers, intelligent switch, and optical sensors.

6.
Eur J Pharmacol ; 954: 175856, 2023 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-37321470

RESUMO

BACKGROUND: The Warburg effect is prevalent in human cancer. Oridonin (ORI) has excellent anticancer effects, but its exact anticancer mechanism is still unclear. METHODS: CCK8, EdU, and flow cytometry assay were performed to detect the effect of ORI on cell viability, proliferation and apoptosis, respectively. RNA-seq was carried out to search the underlying mechanisms. Total PKM2, dimeric PKM2, nuclear PKM2 was detected by Western blot. The epidermal growth factor receptor/extracellular signal regulated kinase (EGFR/ERK) signaling was assayed. The binding ability of Importin-α5 to PKM2 was performed by Co-IP experiments. The effect of ORI combined with cysteine (Cys) or fructose-1, 6-diphosphate (FDP) on cancer cells was detected. Mouse xenograft model was established to confirm the molecular mechanisms in vivo. RESULTS: ORI inhibited viability, proliferation and promoted apoptosis of CRC cells. RNA-seq revealed ORI attenuated the Warburg effect in cancer cells. ORI reduced dimeric PKM2 and prevented it from entering the nucleus. ORI did not affect the EGFR/ERK signaling, but reduced Importin-α5 binding to the PKM2 dimer. Cys or FDP reversed or enhanced the effect of ORI. Animal model assay confirmed the molecular mechanisms in vivo. CONCLUSIONS: Our study first shows that ORI could have anticancer activity by inhibiting the Warburg effect as a novel activator of PKM2.


Assuntos
Neoplasias Colorretais , Receptores ErbB , Animais , Humanos , Camundongos , Linhagem Celular Tumoral , Proliferação de Células , Neoplasias Colorretais/tratamento farmacológico , Carioferinas/farmacologia , Proteínas de Ligação a Hormônio da Tireoide
7.
Materials (Basel) ; 16(8)2023 Apr 16.
Artigo em Inglês | MEDLINE | ID: mdl-37109982

RESUMO

Due to their narrow beam waist size, high intensity, and long propagation distance, photonic nanojets (PNJs) can be used in various fields such as nanoparticle sensing, optical subwavelength detection, and optical data storage. In this paper, we report a strategy to realize an SPP-PNJ by exciting a surface plasmon polariton (SPP) on a gold-film dielectric microdisk. In detail, an SPP is excited by the grating-coupling method, then it irradiates the dielectric microdisk to form an SPP-PNJ. The characteristics of the SPP-PNJ, including maximum intensity, full width at half maximum (FWHM), and propagation distance, are studied by using finite difference time domain (FDTD) numerical solutions. The results demonstrate that the proposed structure can produce a high-quality SPP-PNJ, the maximum quality factor of which is 62.20, and the propagation distance of the SPP-PNJ is 3.08 λ. Furthermore, the properties of the SPP-PNJ can be modified flexibly by changing the thickness and refractive index of the dielectric microdisk.

8.
Phys Chem Chem Phys ; 25(12): 8489-8496, 2023 Mar 22.
Artigo em Inglês | MEDLINE | ID: mdl-36883439

RESUMO

With the development of science and technology, intermediate infrared technology has gained more and more attention in recent years. In the research described in this paper, a tunable broadband absorber based on a Dirac semimetal with a layered resonant structure was designed, which could achieve high absorption (more than 0.9) of about 8.7 THz in the frequency range of 18-28 THz. It was confirmed that the high absorption of the absorber comes from the strong resonance absorption between the layers, and the resonance of the localised surface plasmon. The absorber has a gold substrate, which is composed of three layers of Dirac semimetal and three layers of optical crystal plates. In addition, the resonance frequency of the absorber can be changed by adjusting the Fermi energy of the Dirac semimetal. The absorber also shows excellent characteristics such as tunability, absorption stability at different polarisation waves and incident angles, and has a high application value for use in radar countermeasures, biotechnology and other fields.

9.
J Biophotonics ; 16(5): e202200290, 2023 05.
Artigo em Inglês | MEDLINE | ID: mdl-36541739

RESUMO

We present a cell-phone based polarized microscope for diagnosing malaria through hemozoin recognition over a wide field-of-view (FOV) accompanied with decent image performance. The system is constructed based on attachment method using a lens assembly as objective, two mobile phones and two linear polarizers. A ~0.92 µm resolution across a FOV of ~3.27 mm × 3.27 mm with high imaging quality is realized, demonstrating an increased resolving power, four times improvement in FOV and better imaging quality over mobile-optical-polarization imaging device. Importantly, we also demonstrate it has capability of recognizing hemozoin within the sample for malaria diagnosis by imaging malaria-infected blood samples with similar sensitivity comparable to Leica microscopy. It is more compact, portable, and insensitive to alignment, making it highly suitable for malaria detection in a portable, easy to setup and use way in low-resource areas.


Assuntos
Telefone Celular , Lentes , Malária , Humanos , Microscopia/métodos , Malária/diagnóstico , Imagem Óptica
10.
Opt Express ; 30(26): 46121-46133, 2022 Dec 19.
Artigo em Inglês | MEDLINE | ID: mdl-36558574

RESUMO

Due to the ability of changing light propagation path direction, curved waveguide Bragg grating (CWG) plays an important role in photonic integrated circuits. In this paper, we proposed a cascaded sampled Bragg grating on tilted waveguide (CSBG-TW) structure to equivalently realize CWG. As an example, by designing two-dimensional (2D) sampled gratings, the direction of +1st sub-grating vector in CSBG-TW can be changed. Then if a curved waveguide is divided into several sections of tilted waveguide, we can keep the grating direction being always parallel to the longitudinal direction of each section of tilted waveguide, while the basic grating is uniform. Hence, the required CWG can be equivalently realized, and the light responses such as reflection Bragg wavelength shift and backward mode convert caused by the tilted grating in curved waveguide can be compensated for. The results show that the sampling structures of CSBG-TW is micro-scale and the difference between reflection intensity between the CSBG-TW with four section tilted waveguide and CWG as design target is less than 0.1 dB. Compared with CWG, the CSBG-TW allows convenient holographic exposure and the wavelength can be accurately controlled. Therefore, the CSBG-TW can be used in various photonic integrated devices that require changing propagation paths.

11.
RSC Adv ; 12(50): 32583-32591, 2022 Nov 09.
Artigo em Inglês | MEDLINE | ID: mdl-36425681

RESUMO

This paper proposes a tunable sensing detector based on Bulk Dirac semimetals (BDS). The bottom-middle-top structure of the detector is a metal-dielectric-Dirac semimetal. The designed detector is simulated in the frequency domain by the finite element method (FEM). And the simulation results indicate that the detector achieves three perfect absorption peaks with absorptivity greater than 99.8% in the range of 2.4-5.2 THz. We analyze the cause of the absorption peak by using random phase approximation theory. The device exhibits good angular insensitivity in different incident angle ranges, and the three absorption peaks can reach 90% absorption rate when the incident angle is in the ranges of 0-60°. And when adjusting the Fermi level of BDS in the ranges of 0.1-0.5 eV, our detector can realize the frequency regulation of the ultra-wide range of 3.90-4.56 THz and realize multi-frequency controllable sensing while maintain the absorption efficiency above 96%. The detector has maximum sensitivity S of 238.0 GHz per RIU when the external environment of the refractive index changes from 1.0 to 1.8, and the maximum detection accuracy is 6.5. The device has broad development prospects in the field of space detection and high-sensitivity biosensing detection.

12.
Opt Express ; 30(21): 39055-39067, 2022 Oct 10.
Artigo em Inglês | MEDLINE | ID: mdl-36258455

RESUMO

A surface plasmon resonance (SPR) sensor comprising photonic crystal fiber (PCF) is designed for magnetic field and temperature dual-parameter sensing. In order to make the SPR detection of magnetic field and temperature effectively, the two open ring channels of the proposed sensor are coated with gold and silver layers and filled with magnetic fluid (MF) and Polydimethylsiloxane (PDMS), respectively. The sensor is analyzed by the finite element method and its mode characteristics, structure parameters and sensing performance are investigated. The analysis reveals when the magnetic field is a range of 40-310 Oe and the temperature is a range of 0-60 °C, the maximum magnetic field sensitivity is 308.3 pm/Oe and temperature sensitivity is 6520 pm/°C. Furthermore, temperature and magnetic field do not crosstalk with each other's SPR peak. Its refractive index sensing performance is also investigated, the maximum sensitivity and FOM of the left channel sensing are 16820 nm/RIU and 1605 RIU-1, that of the right channel sensing are 13320 nm/RIU and 2277 RIU-1. Because of its high sensitivity and special sensing performance, the proposed sensor will have potential application in solving the problems of cross-sensitivity and demodulation due to nonlinear changes in sensitivity of dual-parameter sensing.

13.
Sensors (Basel) ; 22(17)2022 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-36080942

RESUMO

The paper proposes an ultra-narrow band graphene refractive index sensor, consisting of a patterned graphene layer on the top, a dielectric layer of SiO2 in the middle, and a bottom Au layer. The absorption sensor achieves the absorption efficiency of 99.41% and 99.22% at 5.664 THz and 8.062 THz, with the absorption bandwidths 0.0171 THz and 0.0152 THz, respectively. Compared with noble metal absorbers, our graphene absorber can achieve tunability by adjusting the Fermi level and relaxation time of the graphene layer with the geometry of the absorber unchanged, which greatly saves the manufacturing cost. The results show that the sensor has the properties of polarization-independence and large-angle insensitivity due to the symmetric structure. In addition, the practical application of testing the content of hemoglobin biomolecules was conducted, the frequency of first resonance mode shows a shift of 0.017 THz, and the second resonance mode has a shift of 0.016 THz, demonstrating the good frequency sensitivity of our sensor. The S (sensitivities) of the sensor were calculated at 875 GHz/RIU and 775 GHz/RIU, and quality factors FOM (Figure of Merit) are 26.51 and 18.90, respectively; and the minimum limit of detection is 0.04. By comparing with previous similar sensors, our sensor has better sensing performance, which can be applied to photon detection in the terahertz band, biochemical sensing, and other fields.


Assuntos
Grafite , Refratometria , Metais , Refração Ocular , Dióxido de Silício
14.
RSC Adv ; 12(33): 21264-21269, 2022 Jul 21.
Artigo em Inglês | MEDLINE | ID: mdl-35975043

RESUMO

Possessing fantastic abilities to freely manipulate electromagnetic waves on an ultrathin platform, metasurfaces have aroused intense interest in the academic circle. In this work, we present a high-sensitivity refractive index sensor excited by the guided mode of a two-dimensional periodic TiO2 dielectric grating structure. Numerical simulation results show that the optimized nanosensor can excite guided-mode resonance with an ultra-narrow linewidth of 0.19 nm. When the thickness of the biological layer is 20 nm, the sensitivity, Q factor, and FOM values of the nanosensor can reach 82.29 nm RIU-1, 3207.9, and 433.1, respectively. In addition, the device shows insensitivity to polarization and good tolerance to the angle of incident light. This demonstrates that the utilization of low-loss all-dielectric metasurfaces is an effective way to achieve ultra-sensitive biosensor detection.

15.
RSC Adv ; 12(13): 7821-7829, 2022 Mar 08.
Artigo em Inglês | MEDLINE | ID: mdl-35424732

RESUMO

In this paper, a multi-mode surface plasmon resonance absorber based on dart-type single-layer graphene is proposed, which has the advantages of polarization independence, tunability, high sensitivity, high figure of merit, etc. The device consists of a top layer dart-like patterned single-layer graphene array, a thicker silicon dioxide spacer layer and a metal reflector layer, and has simple structural characteristics. The numerical results show that the device achieves the perfect polarization-independent absorption at the resonance wavelengths of λ I = 3369.55 nm, λ II = 3508.35 nm, λ III = 3689.09 nm and λ IV = 4257.72 nm, with the absorption efficiencies of 99.78%, 99.40%, 99.04% and 99.91%, respectively. The absorption effect of the absorber can be effectively regulated and controlled by adjusting the numerical values such as the geometric parameters and the structural period p of the single-layer graphene array. In addition, by controlling the chemical potential and the relaxation time of the graphene layer, the resonant wavelength and the absorption efficiency of the mode can be dynamically tuned. And can keep high absorption in a wide incident angle range of 0° to 50°. At last, we exposed the structure to different environmental refractive indices, and obtained the corresponding maximum sensitivities in four resonance modes, which are S I = 635.75 nm RIU-1, S II = 695.13 nm RIU-1, S III = 775.38 nm RIU-1 and S IV = 839.39 nm RIU-1. Maximum figure of merit are 54.03 RIU-1, 51.49 RIU-1, 43.56 RIU-1, and 52.14 RIU-1, respectively. Therefore, this study has provided a new inspiration for the design of the graphene-based tunable multi-band perfect metamaterial absorber, which can be applied to the fields such as photodetectors and chemical sensors.

16.
Micromachines (Basel) ; 13(3)2022 Feb 23.
Artigo em Inglês | MEDLINE | ID: mdl-35334641

RESUMO

Using the finite-difference time-domain (FDTD) method, we designed an ultra-thin Ge/GaAs/P3HT:PCBM hybrid solar cell (HSC), which showed good effects of ultra-wideband (300 nm-1200 nm), high absorption, and a short-circuit current density of 44.7 mA/cm2. By changing the thickness of the active layer P3HT:PCBM, we analyzed the capture of electron-hole pairs. We also studied the effect of Al2O3 on the absorption performance of the cell. Through adding metal Al nanoparticles (Al-NPs) and then analyzing the figures of absorption and electric field intensity, we found that surface plasma is the main cause of solar cell absorption enhancement, and we explain the mechanism. The results show that the broadband absorption of the solar cell is high, and it plays a great role in capturing sunlight, which will be of great significance in the field of solar cell research.

17.
Phys Chem Chem Phys ; 24(15): 8846-8853, 2022 Apr 13.
Artigo em Inglês | MEDLINE | ID: mdl-35356962

RESUMO

We present a novel, structurally simple, multifunctional broadband absorber. It consists of a patterned vanadium dioxide film and a metal plate spaced by a dielectric layer. Temperature control allows flexible adjustment of the absorption intensity from 0 to 0.999. The modulation mechanism of the absorber stems from the thermogenic phase change properties of the vanadium dioxide material. The absorber achieves total reflection properties in the terahertz band when the vanadium dioxide is in the insulated state. When the vanadium dioxide is in its metallic state, the absorber achieves near-perfect absorption in the ultra-broadband range of 3.7 THz-9.7 THz. Impedance matching theory and the analysis of electric field are also used to illustrate the mechanism of operation. Compared to previous reports, our structure utilizes just a single cell structure (3 layers only), and it is easy to process and manufacture. The absorption rate and operating bandwidth of the absorber are also optimised. In addition, the absorber is not only insensitive to polarization, but also very tolerant to the angle of incidence. Such a design would have great potential in wide-ranging applications, including photochemical energy harvesting, stealth devices, thermal emitters, etc.

18.
Demography ; 59(2): 485-509, 2022 04 01.
Artigo em Inglês | MEDLINE | ID: mdl-35212718

RESUMO

Over the past two decades, opioid overdose deaths contributed to the dramatic rise in all-cause mortality among non-Hispanic Whites. To date, efforts among scholars to understand the role of local area labor market conditions on opioid overdose mortality have led to mixed results. We argue the reason for these disparate findings is scholars have not considered the moderating effects of income support policies such as unemployment insurance. The present study leverages two sources of variation-county mass layoffs and changes in the generosity of state unemployment insurance benefits-to investigate if unemployment benefits moderate the relationship between job loss and county opioid overdose death rates. Our difference-in-differences estimation strategy reveals that the harmful effects of job loss on opioid overdose mortality decline with increasing state unemployment insurance benefit levels. These findings suggest that social policy in the form of income transfers played a crucial role in disrupting the link between job loss and opioid overdose mortality.


Assuntos
Overdose de Drogas , Seguro , Overdose de Opiáceos , Analgésicos Opioides , Humanos , Desemprego , Estados Unidos/epidemiologia
19.
Phys Chem Chem Phys ; 24(8): 4871-4880, 2022 Feb 23.
Artigo em Inglês | MEDLINE | ID: mdl-35136890

RESUMO

In this work, we demonstrate that the performance of c-Si/ZnO heterojunction ultrathin-film solar cells (SCs) is enhanced by an integrated structure of c-Si trapezoidal pyramids on the top of a c-Si active layer and Al pyramids in the active layer on the Al back electrode. The top c-Si trapezoidal pyramid (TTP) increases the absorption of short wavelengths by lengthening the propagation distance of incident light and coupling the incident light into photonic modes in the active layer. The bottom Al pyramid (BP) improves the overall optical absorption performance especially for the long wavelength band by forming the surface plasmon resonance (SPR) mode in the active layer. As a result, the average absorption in the entire wavelength range (300-1400 nm) reaches 93.16%. The optimized short-circuit current density (Jsc) and photoelectric conversion efficiency (PCE) of ultra-thin film c-Si/ZnO SCs are 41.94 mA cm-2 and 18.97%, respectively. Moreover, the effect of different illumination angles on the optical absorption of the SCs was explored. The SCs have good absorption when the incident angles are in the range from 0 degrees to 60 degrees. Furthermore, the underlying mechanism for the enhancement of photon absorption in the SCs was discussed through careful analysis of the electric field intensity profile at different wavelengths. It was found that the electric field tends to concentrate around the bottom pyramids and top trapezoidal pyramids even for the long-wave band, which results in an excellent light-trapping performance.

20.
Phys Chem Chem Phys ; 24(4): 2527-2533, 2022 Jan 26.
Artigo em Inglês | MEDLINE | ID: mdl-35023523

RESUMO

Terahertz functional devices have been instrumental in the development of terahertz technology. Moreover, the advent of metamaterials has greatly contributed to the advancement of terahertz devices. However, most of today's metamaterials in the terahertz band exhibit poor performance and are mono-functional. This greatly limits the scalability and application potential of the devices. To achieve diversification and tunability of device functionality, we propose a combination of metamaterial structures and vanadium dioxide film. A metamaterial absorber based on the thermotropic phase change material VO2 has been designed. Flexible switching of absorption performance (complete reflection and ultra-broadband perfect absorption) can be achieved through temperature adjustment. Moreover, the perfectly absorbed bandwidth is a staggering 3.3 THz. The thermal tuning of spectral absorbance has a maximal range of 0.01 to 0.999. The shift in absorption properties is explained by the phase change process of vanadium oxide (MIT). The electric field intensity on the absorber surface at different temperatures was monitored and analysed as a way to correlate the VO2 film phase transition process. The impedance matching theory is applied to explain the high level of absorption generated by the absorber. Finally, the effects of the structural parameters on the performance of the absorber are analysed. This work will have many applications in the terahertz field and offers a wide range of ideas for the design of terahertz-enabled devices.

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