Dolutegravir-based antiretroviral therapy in a severely overweight child with a multidrug-resistant human immunodeficiency virus infection. A case report and review.

The management of multidrug-resistant human immunodeficiency virus (MDR HIV) infections in children is particularly challenging due to the lack of experience with new drugs. Dolutegravir, combined with an optimized antiretroviral background therapy, is promising for the treatment of MDR HIV and has been approved recently for adults and adolescents. Data for children are extremely limited. We describe the efficacy, safety and plasmatic levels of a dolutegravir-based, complex active antiretroviral treatment regimen in a severely overweight 11-year-old child infected with an MDR HIV strain.

Corrigendum to "Dolutegravir-based antiretroviral therapy in a severely overweight child with a multi-drug resistant human immunodeficiency virus infection. A case report and review" [New Microbes New Infect] 6 (2015) 1-4].

[This corrects the article DOI: 10.1016/j.nmni.2015.02.003.].

Large measles outbreak in Geneva, Switzerland, January to August 2011: descriptive epidemiology and demonstration of quarantine effectiveness.

Between January and August 2011, the canton of Geneva, Switzerland, experienced a large measles outbreak with 219 cases (47 cases per 100,000 inhabitants) in the context of an extensive epidemic in a neighbouring region of France. Most cases were young adults (median age: 18 years), often unaware of their vaccination status. The vast majority of cases were either not (81%) or incompletely vaccinated (8%). Thirty clusters with a total of 119 cases and a median cluster size of three (range: 2­15 cases) were identified. Overall, 44 cases were imported or linked to imported cases. Of 73 contacts of cases who were quarantined, 50 developed measles and caused six secondary cases. This compares to 81 secondary cases among 173 non-quarantined cases (relative risk: 0.26; 95% confidence interval: 0.06­0.65), demonstrating the effectiveness of well targeted quarantine measures in reducing transmission.

Ongoing measles outbreak, Geneva, Switzerland, January to March 2011.

An outbreak of measles is ongoing in Geneva, Switzerland, since January 2011, in the context of a measles epidemic in neighbouring Rhône-Alpes, France. A total of 41 confirmed cases have been reported, the majority among young adults, many unaware of their non-immune status. There is no large clustering of cases and 14 cases were imported or linked to imported cases. Catch-up vaccination, especially among young adults, may be necessary to prevent further extension of this outbreak.

[Evolution of vaccine coverage from school year 2003-2004 to 2006-2007, for 5 to 6-year-old children in Geneva]. / Evolution de la couverture vaccinale de l'année scolaire 2003-2004 à 2007-2008 pour les enfants de cinq à six ans à Genève.

OBJECTIVE: The authors had for aim to study the evolution of vaccination coverage for diphtheria, tetanus, pertussis, poliomyelitis, measles, mumps, rubella (MMR) and Haemophilus influenzae b (Hib) in 5 to 6-year-old children in Geneva, from school year 2003-2004 to 2006-2007. DESIGN: The data was collected from vaccination cards of 17,184 children attending public schools in the Geneva canton. RESULTS: The average vaccination coverage over the study period was 93.4% for diphtheria, 93.5% for tetanus, 92.5% for pertussis, and 92.4% for poliomyelitis. For MMR and Hib, the coverage was 80.6, 78.4, 79.1 and 81.2% respectively. Between 2003 and 2007, an increase of coverage was observed for all vaccines. It was especially observed for MMR and Hib vaccines, even though the coverage remained below 90%. CONCLUSION: In the Geneva canton, epidemiological surveillance of vaccination coverage of 5 to 6-year-old children can be achieved through systematic data analysis of children's vaccination cards. All commonly used vaccines reached the recommended coverage rates, except for MMR and Hib, even though their coverage had significantly increased.

[The role of primary care physicians in the detection and control of epidemics: the Geneva experience]. / Veille et alerte sanitaire: a place des médecins de ville à Genève, Suisse.

Private practice physicians play a central role in the detection and control of outbreaks. In Geneva, a local alert and response network completes the federal surveillance system, based on the mandatory reporting of infectious diseases. The common objective of these two mechanisms is to help health authorities in detecting, assessing, and controlling infectious diseases treats. Private practice physicians are one of the most effective and timely sources of information. As network members, they receive brief reports and information and are involved in the implementation of control and prevention measures. Their key-role was confirmed during a measles epidemic which occurred in Geneva in the spring of 2003.

[Contribution of unvaccinated siblings to a measles outbreak in Switzerland]. / Contribution des fratries non vaccinées à une flambée de rougeole en Suisse.

BACKGROUND: A measles outbreak occurred in Geneva between March and July 2003. An investigation was conducted to determine its magnitude, identify predominant modes of transmission, and assess disease outcome. METHODS: In Switzerland, measles notification has been mandatory for physicians since 1999 and laboratories since 1988. All cases were investigated and followed up by interviewing physicians using a standardized questionnaire. Viral genotype was determined for 4 cases using a saliva specimen processed at the Robert Koch Institute, Berlin. Geographic distribution of cases and vaccination coverage were compared. RESULTS: Overall, 54 cases were notified. Fifty-three cases were between 10 and 19 years of age. Ninety-four percent (n = 46) of 49 cases with known vaccination status were not vaccinated and none were fully immunized (2 doses). Measles complications occurred among 19% (n = 7) of the 36 patients with follow up information: pneumonia (n = 4, combined with pericarditis and hepatitis in one case) and bronchitis (n = 3). Three persons were hospitalized. No complication was reported among 3 persons partially vaccinated (1 dose). The virus belonged to genotypes D8 and D5. Five separate clusters of related cases included 74% of all cases. Transmission mainly occurred within families (43% of all cases) and school (28%). Two of the most affected areas had measles vaccination coverage well below the cantonal average. CONCLUSION: Low vaccination coverage combined with clusters of unvaccinated household contributed to continued virus circulation and represents a threat to the canton of Geneva as new outbreaks of measles may reoccur.