[Experimental study on in vitro transdermal absorption of Shangshi Zhitong cataplasm].

OBJECTIVE: To conduct an experimental study on in vitro transdermal absorption of prepared Shangshi Zhitong cataplasm. METHOD: Franz diffusing cells and mice were adopted for the percutaneous penetration study. The accumulative percutaneous permeation of total alkaloids, strychnine and atropine in certain time was determined by acid dye colorimetry and HPLC. RESULT: The accumulative permeation of alkaloids (Q) increased with time (t), with a linear relation between them. CONCLUSION: The in vitro percutaneous penetration of Shangshi Zhitong cataplasm complies with the zero-order kinetics.