[Multisystem inflammatory syndrome in children in the context of coronavirus disease 2019 pandemic]. / æ–°åž‹å† çŠ¶ç— æ¯’æ„ŸæŸ“æµè¡ŒèƒŒæ™¯ä¸‹çš„å„¿ç«¥å¤šç³»ç»Ÿç‚Žç—‡ç»¼åˆå¾.

Multisystem inflammatory syndrome in children (MIS-C) is a complex syndrome characterized by multi-organ involvement that has emerged in the context of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak. The clinical presentation of MIS-C is similar to Kawasaki disease but predominantly presents with fever and gastrointestinal symptoms, and severe cases can involve toxic shock and cardiac dysfunction. Epidemiological findings indicate that the majority of MIS-C patients test positive for SARS-CoV-2 antibodies. The pathogenesis and pathophysiology of MIS-C remain unclear, though immune dysregulation following SARS-CoV-2 infection is considered a major contributing factor. Current treatment approaches for MIS-C primarily involve intravenous immunoglobulin therapy and symptomatic supportive care. This review article provides a comprehensive overview of the definition, epidemiology, pathogenesis, clinical presentation, diagnosis, treatment, and prognosis of MIS-C.

A Cu(OTf)2-Catalyzed Glycosylation with Glycosyl ortho-N-Phthalimidoylpropynyl Benzoates as Donors.

A Cu(OTf)2-catalyzed glycosylation protocol using glycosyl ortho-N-phthalimidoylpropynyl benzoates (NPPBs) as donors was disclosed, which features an inexpensive copper catalyst, operationally convenient conditions, high to excellent yields, and a broad substrate scope. Mechanistic studies indicated an isochromen-4-yl copper(II) intermediate arising from the departure of the leaving group.

[Interpretation of the JCS/JSCS 2020 guideline on diagnosis and management of cardiovascular sequelae in Kawasaki disease].

Kawasaki disease is the main cause of acquired heart disease in children. The cardiovascular sequelae of Kawasaki disease, such as coronary artery lesion and giant coronary aneurysm, have a great impact on children's physical and mental health. The Japanese Circulatory Society and the Japanese Society of Cardiac Surgery jointly released the JCS/JSCS 2020 guideline on diagnosis and management of cardiovascular sequelae in Kawasaki disease in July, 2020, which systematically introduces the advances in the diagnosis and management of cardiovascular sequelae of Kawasaki disease. The article gives an interpretation in the severity evaluation of Kawasaki disease and diagnosis, treatment and long-term management of cardiovascular sequelae in the guideline.

[Expression of DeltaNp63 protein in nasopharyngeal carcinoma and its significance].

BACKGROUND & OBJECTIVE: The molecular etiology of nasopharyngeal carcinoma is currently unknown. It was reported that DeltaNp63 is dominant-negative toward transactivation of p53, and associated with the malignant hyperplasia and dedifferentiation of the squamous cells. This study was designed to investigate the expression and significance of DeltaNp63 protein in NPC tissues. METHODS: Immunohistochemical method was used to determine the expression of DeltaNp63 in 60 cases of NPC, 37 cases of nearby mucosa of the carcinoma, and 30 cases of chronic inflammation of nasopharyngeal mucosa. The classification of the 60 NPC cases were as follows: 3 cases of keratinizing squamous cell carcinomas, 57 cases of nonkeratinizing carcinomas including 12 cases of undifferentiated carcinomas. RESULTS: All 60 NPC cases showed DeltaNp63 positive reaction. Keratinizing squamous cell carcinomas showed weakly positive expression; 66.67% (38/57) of nonkeratinizing carcinomas showed strongly positive reaction, and 83.33% (10/12) of undifferentiated carcinomas showed strongly positive reaction. Chronic inflammation mucosas and cancer nearby mucosas showed positive reaction only in their basal and superbasal cells. CONCLUSION: DeltaNp63 protein was found to be closely associated with cell malignant hyperplasia. DeltaNp63 protein has distinct tendency to the infantile or anaplastic squamous cells, and DeltaNp63 protein is a valuable diagnostic marker for anaplastic squamous cells.