Priming of hippocampal microglia by IFN-γ/STAT1 pathway impairs social memory in mice.

Social behavior is inextricably linked to the immune system. Although IFN-γ is known to be involved in social behavior, yet whether and how it encodes social memory remains unclear. In the current study, we injected with IFN-γ into the lateral ventricle of male C57BL/6J mice, and three-chamber social test was used to examine the effects of IFN-γ on their social preference and social memory. The morphology of microglia in the hippocampus, prelimbic cortex and amygdala was examined using immunohistochemistry, and the phenotype of microglia were examined using immunohistochemistry and enzyme-linked immunosorbent assays. The IFN-γ-injected mice were treated with lipopolysaccharide, and effects of IFN-γ on behavior and microglial responses were evaluated. STAT1 pathway and microglia-neuron interactions were examined in vivo or in vitro using western blotting and immunohistochemistry. Finally, we use STAT1 inhibitor or minocycline to evaluated the role of STAT1 in mediating the microglial priming and effects of primed microglia in IFN-γ-induced social dysfunction. We demonstrated that 500 ng of IFN-γ injection results in significant decrease in social index and social novelty recognition index, and induces microglial priming in hippocampus, characterized by enlarged cell bodies, shortened branches, increased expression of CD68, CD86, CD74, CD11b, CD11c, CD47, IL-33, IL-1ß, IL-6 and iNOS, and decreased expression of MCR1, Arg-1, IGF-1 and BDNF. This microglia subpopulation is more sensitive to LPS challenge, which characterized by more significant morphological changes and inflammatory responses, as well as induced increased sickness behaviors in mice. IFN-γ upregulated pSTAT1 and STAT1 and promoted the nuclear translocation of STAT1 in the hippocampal microglia and in the primary microglia. Giving minocycline or STAT1 inhibitor fludarabin blocked the priming of hippocampal microglia induced by IFN-γ, ameliorated the dysfunction in hippocampal microglia-neuron interactions and synapse pruning by microglia, thereby improving social memory deficits in IFN-γ injected mice. IFN-γ initiates STAT1 pathway to induce priming of hippocampal microglia, thereby disrupts hippocampal microglia-neuron interactions and neural circuit link to social memory. Blocking STAT1 pathway or inhibiting microglial priming may be strategies to reduce the effects of IFN-γ on social behavior.

An Electrode-Crosstalk-Suppressing Smart Polymer Electrolyte for High Safety Lithium-Ion Batteries.

Electrode crosstalk between anode and cathode at elevated temperatures is identified as a real culprit triggering the thermal runaway of lithium-ion batteries. Herein, to address this challenge, a novel smart polymer electrolyte is prepared through in situ polymerization of methyl methacrylate and acrylic anhydride monomers within a succinonitrile-based dual-anion deep eutectic solvent. Owing to the abundant active unsaturated double bonds on the as-obtained polymer matrix end, this smart polymer electrolyte can spontaneously form a dense crosslinked polymer network under elevated temperatures, effectively slowing down the crosstalk diffusion kinetics of lithium ions and active gases. Impressively, LiCoO2/graphite pouch cells employing this smart polymer electrolyte demonstrate no thermal runaway even at the temperature up to 250 °C via accelerating rate calorimeter testing. Meanwhile, because of its abundance of functional motifs, this smart polymer electrolyte can facilitate the formation of stable and thermally robust electrode/electrolyte interface on both electrodes, ensuring the long cycle life and high safety of LIBs. In specific, this smart polymer electrolyte endows 1.1 Ah LiCoO2/graphite pouch cell with a capacity retention of 96% after 398 cycles at 0.2 C.

A Highly-Fluorinated Lithium Borate Main Salt Empowering Stable Lithium Metal Batteries.

Traditional lithium salts are difficult to meet practical application demand of lithium metal batteries (LMBs) under high voltages and temperatures. LiPF6, as the most commonly used lithium salt, still suffers from notorious moisture sensitivity and inferior thermal stability under those conditions. Here, we synthesize a lithium salt of lithium perfluoropinacolatoborate (LiFPB) comprising highly-fluorinated and borate functional groups to address the above issues. It is demonstrated that the LiFPB shows superior thermal and electrochemical stability without any HF generation under high temperatures and voltages. In addition, the LiFPB can form a protective outer-organic and inner-inorganic rich cathode electrolyte interphase on LiCoO2 (LCO) surface. Simultaneously, the FPB- anions tend to integrate into lithium ion solvation structure to form a favorable fast-ion conductive LiBxOy based solid electrolyte interphase on lithium (Li) anode. All these fantastic features of LiFPB endow LCO (1.9 mAh cm-2)/Li metal cells excellent cycling under both high voltages and temperatures (e.g., 80 % capacity retention after 260 cycles at 60 °C and 4.45 V), and even at an extremely elevated temperature of 100 °C. This work emphasizes the important role of salt anions in determining the electrochemical performance of LMBs at both high temperature and voltage conditions.

Interphase Regulation by Multifunctional Additive Empowering High Energy Lithium-Ion Batteries with Enhanced Cycle Life and Thermal Safety.

High energy density lithium-ion batteries (LIBs) adopting high-nickel layered oxide cathodes and silicon-based composite anodes always suffer from unsatisfied cycle life and poor safety performance, especially at elevated temperatures. Electrode /electrolyte interphase regulation by functional additives is one of the most economic and efficacious strategies to overcome this shortcoming. Herein, cyano-groups (-CN) are introduced into lithium fluorinated phosphate to synthesize a novel multifunctional additive of lithium tetrafluoro (1,2-dihydroxyethane-1,1,2,2-tetracarbonitrile) phosphate (LiTFTCP), which endows high nickel LiNi0.8 Co0.1 Mn0.1 O2 /SiOx -graphite composite full cell with an ultrahigh cycle life and superior safety characteristics, by adding only 0.5 wt % LiTFTCP into a LiPF6 -carbonate baseline electrolyte. It is revealed that LiTFTCP additive effectively suppresses the HF generation and facilitates the formation of a robust and heat-resistant cyano-enriched CEI layer as well as a stable LiF-enriched SEI layer. The favorable SEI/CEI layers greatly lessen the electrode degradation, electrolyte consumption, thermal-induced gassing and total heat-releasing. This work illuminates the importance of additive molecular engineering and interphase regulation in simultaneously promoting the cycling and thermal safety of LIBs with high-nickel NCMxyz cathode and silicon-based composite anode.

Electrolyte Engineering Toward High Performance High Nickel (Ni ≥ 80%) Lithium-Ion Batteries.

High nickel (Ni ≥ 80%) lithium-ion batteries (LIBs) with high specific energy are one of the most important technical routes to resolve the growing endurance anxieties. However, because of their extremely aggressive chemistries, high-Ni (Ni ≥ 80%) LIBs suffer from poor cycle life and safety performance, which hinder their large-scale commercial applications. Among varied strategies, electrolyte engineering is very powerful to simultaneously enhance the cycle life and safety of high-Ni (Ni ≥ 80%) LIBs. In this review, the pivotal challenges faced by high-Ni oxide cathodes and conventional LiPF6 -carbonate-based electrolytes are comprehensively summarized. Then, the functional additives design guidelines for LiPF6 -carbonate -based electrolytes and the design principles of high voltage resistance/high safety novel electrolytes are systematically elaborated to resolve these pivotal challenges. Moreover, the proposed thermal runaway mechanisms of high-Ni (Ni ≥ 80%) LIBs are also reviewed to provide useful perspectives for the design of high-safety electrolytes. Finally, the potential research directions of electrolyte engineering toward high-performance high-Ni (Ni ≥ 80%) LIBs are provided. This review will have an important impact on electrolyte innovation as well as the commercial evolution of high-Ni (Ni ≥ 80%) LIBs, and also will be significant to breakthrough the energy density ceiling of LIBs.

Self-Standing Single-Ion Borate Salt-Based Polymer Electrolyte for Lithium Metal Batteries.

Polymer electrolytes (PEs) with excellent flexibility and superior compatibility toward lithium (Li) metal anodes have been deemed as one of the most promising alternatives to liquid electrolytes. However, conventional lithium bis(trifluoromethanesulfonyl)imide (LiTFSI)-based dual-ion PEs suffer from a low Li ion transference number and notorious Li dendrite growth. Here, a single-ion conducting polyborate salt without any fluorinated groups, polymeric lithium dihydroxyterephthalic acid borate (PLDPB), is presented for addressing the issues of Li metal batteries. Owing to a nearly immovable bulky anion and the presence of a rigid benzene structure, the PLDPB@poly(ethylene oxide) (PEO) PE exhibits an ultrahigh Li ion transference number (0.94) and excellent mechanical strength, which could significantly restrict the growth of Li dendrites. Postmortem analysis reveals that a fluorine-free solid electrolyte interphase (SEI) enriched with B-O and benzene-containing species is formed on the surface of the Li metal anode, thereby facilitating elimination of excessive parasitic reactions and simultaneously suppressing the formation of Li dendrites. Consequently, the LiFePO4/Li cells with PLDPB@PEO PEs show an improved long-term cycling performance and high capacity retention (90.0%) and Coulombic efficiency (99.9%) after 500 cycles. This work may inspire new ideas to boost the development of single-ion conducting salts for dendrite-free Li metal batteries.

Recent Progress of Droplet Microfluidic Emulsification Based Synthesis of Functional Microparticles.

The remarkable control function over the functional material formation process enabled by droplet microfluidic emulsification approaches can lead to the efficient and one-step encapsulation of active substances in microparticles, with the microparticle characteristics well regulated. In comparison to the conventional fabrication methods, droplet microfluidic technology can not only construct microparticles with various shapes, but also provide excellent templates, which enrich and expand the application fields of microparticles. For instance, intersection with disciplines in pharmacy, life sciences, and others, modifying the structure of microspheres and appending functional materials can be completed in the preparation of microparticles. The as-prepared polymer particles have great potential in a wide range of applications for chemical analysis, heavy metal adsorption, and detection. This review systematically introduces the devices and basic principles of particle preparation using droplet microfluidic technology and discusses the research of functional microparticle formation with high monodispersity, involving a plethora of types including spherical, nonspherical, and Janus type, as well as core-shell, hole-shell, and controllable multicompartment particles. Moreover, this review paper also exhibits a critical analysis of the current status and existing challenges, and outlook of the future development in the emerging fields has been discussed.

From materials to clinical use: advances in 3D-printed scaffolds for cartilage tissue engineering.

Osteoarthritis caused by articular cartilage defects is a particularly common orthopedic disease that can involve the entire joint, causing great pain to its sufferers. A global patient population of approximately 250 million people has an increasing demand for new therapies with excellent results, and tissue engineering scaffolds have been proposed as a potential strategy for the repair and reconstruction of cartilage defects. The precise control and high flexibility of 3D printing provide a platform for subversive innovation. In this perspective, cartilage tissue engineering (CTE) scaffolds manufactured using different biomaterials are summarized from the perspective of 3D printing strategies, the bionic structure strategies and special functional designs are classified and discussed, and the advantages and limitations of these CTE scaffold preparation strategies are analyzed in detail. Finally, the application prospect and challenges of 3D printed CTE scaffolds are discussed, providing enlightening insights for their current research.

MWCNTs-GNPs Reinforced TPU Composites with Thermal and Electrical Conductivity: Low-Temperature Controlled DIW Forming.

As an effective technique for fabricating conductive and thermally conductive polymer composites, a multi-filler system incorporates different types and sizes of multiple fillers to form interconnected networks with improved electrical, thermal, and processing properties. In this study, DIW forming of bifunctional composites was achieved by controlling the temperature of the printing platform. The study was based on enhancing the thermal and electrical transport properties of hybrid ternary polymer nanocomposites with multi-walled carbon nanotubes (MWCNTs) and graphene nanoplates (GNPs). With thermoplastic polyurethane (TPU) used as the matrix, the addition of MWCNTs, GNPs and both mixtures further improved the thermal conductivity of the elastomers. By adjusting the weight fraction of the functional fillers (MWCNTs and GNPs), the thermal and electrical properties were gradually explored. Here, the thermal conductivity of the polymer composites increased nearly sevenfold (from 0.36 W·m-1·k-1 to 2.87 W·m-1·k-1) and the electrical conductivity increased up to 5.49 × 10-2 S·m-1. It is expected to be used in the field of electronic packaging and environmental thermal dissipation, especially for modern electronic industrial equipment.

Revealing Capacity Degradation of Ge Anodes in Lithium-Ion Batteries Triggered by Interfacial LiH.

The Germanium (Ge), as a fast-charging and high specific capacity (1568 mAh g-1 ) alloy anode, is greatly hampered in practical application by poor cyclability. To date, the understanding of cycling performance degradation remains elusive. This study illustrates that, contrary to conventional beliefs, most of the Ge material in failed anodes still retains good integrity and does not undergo severe pulverization. It is revealed that capacity degradation is clearly correlated to the interfacial evolution of lithium hydride (LiH). Tetralithium germanium hydride (Li4 Ge2 H), as a new species derived from LiH, is identified as the culprit of Ge anode degradation, which is the dominant crystalized component in an ever-growing and ever-insulating interphase. The significantly increased thickness of the solid electrolyte interface (SEI) is accompanied by the accumulation of insulating Li4 Ge2 H upon cycling, which severely retards the charge transport process and ultimately triggers the anode failure. We believe that the comprehensive understanding of the failure mechanism presented in this study is of great significance to promoting the design and development of alloy anode for the next generation of lithium-ion batteries.

Highly Oxidative-Resistant Cyano-Functionalized Lithium Borate Salt for Enhanced Cycling Performance of Practical Lithium-Ion Batteries.

Lithium difluoro(oxalato) borate (LiDFOB) has been widely investigated in lithium-ion batteries (LIBs) owing to its advantageous thermal stability and excellent aluminum passivation property. However, LiDFOB tends to suffer from severe decomposition and generate a lot of gas species (e.g., CO2 ). Herein, a novel cyano-functionalized lithium borate salt, namely lithium difluoro(1,2-dihydroxyethane-1,1,2,2-tetracarbonitrile) borate (LiDFTCB), is innovatively synthesized as a highly oxidative-resistant salt to alleviate above dilemma. It is revealed that the LiDFTCB-based electrolyte enables LiCoO2 /graphite cells with superior capacity retention at both room and elevated temperatures (e.g., 80 % after 600 cycles) with barely any CO2 gas evolution. Systematic studies reveal that LiDFTCB tends to form thin and robust interfacial layers at both electrodes. This work emphasizes the crucial role of cyano-functionalized anions in improving cycle lifespan and safety of practical LIBs.

A Novel Potassium Salt Regulated Solvation Chemistry Enabling Excellent Li-Anode Protection in Carbonate Electrolytes.

In lithium-metal batteries (LMBs), the compatibility of Li anode and conventional lithium hexafluorophosphate-(LiPF6 ) carbonate electrolyte is poor owing to the severe parasitic reactions. Herein, to resolve this issue, a delicately designed additive of potassium perfluoropinacolatoborate (KFPB) is unprecedentedly synthesized. On the one hand, KFPB additive can regulate the solvation structure of the carbonate electrolyte, promoting the formation of Li+ FPB- and K+ PF6 - ion pairs with lower lowest unoccupied molecular orbital (LUMO) energy levels. On the other hand, FPB- anion possesses strong adsorption ability on Li anode. Thus, anions can preferentially adsorb and decompose on the Li-anode surface to form a conductive and robust solid-electrolyte interphase (SEI) layer. Only with a trace amount of KFPB additive (0.03 m) in the carbonate electrolyte, Li dendrites' growth can be totally suppressed, and Li||Cu and Li||Li half cells exhibit excellent Li-plating/stripping stability upon cycling. Encouragingly, KFPB-assisted carbonate electrolyte enables high areal capacity LiCoO2 ||Li, LiNi0.8 Co0.1 Mn0.1 O2 (NCM811)||Li, and LiNi0.8 Co0.05 Al0.15 O2 (NCA)||Li LMBs with superior cycling stability, showing its excellent universality. This work reveals the importance of designing novel additives to regulate the solvation structure of carbonate electrolytes in improving its interface compatibility with the Li anode.

Variable Stiffness Conductive Composites by 4D Printing Dual Materials Alternately.

Materials that can be designed with programmable properties and which change in response to external stimuli are of great importance in numerous fields of soft actuators, involving robotics, drug delivery and aerospace applications. In order to improve the interaction of human and robots, materials with variable stiffness are introduced to develop their compliance. A variable stiffness composite has been investigated in this paper, which is composed of liquid metals (LMs) and silicone elastomers. The phase changing materials (LMs) have been encapsulated into silicone elastomer by printing the dual materials alternately with three-dimensional direct ink writing. Such composites enable the control over their own stiffness between soft and rigid states through LM effective phase transition. The tested splines demonstrated that the stiffness changes approximately exceeded 1900%, and the storage modulus is 4.75 MPa and 0.2 MPa when LM is rigid and soft, respectively. In the process of heating up, the stretching strain can be enlarged by at least three times, but the load capacity is weakened. At a high temperature, the resistance of the conductive composites changes with the deformation degree, which is expected to be applied in the field of soft sensing actuators.

Delicately Tailored Ternary Phosphate Electrolyte Promotes Ultrastable Cycling of Na3V2(PO4)2F3-Based Sodium Metal Batteries.

High-voltage sodium metal batteries are a highly intriguing battery technology in view of their resource sustainability, cost efficiency, and ultrahigh energy density. However, developing a high-performance electrolyte, compatible with both high-voltage cathodes and highly reactive sodium metal anodes, is extremely challenging. In this work, we delicately formulate a ternary phosphate electrolyte, composing of a cost-effective sodium bis(trifluoromethane sulfonyl) imide salt, a nonflammable triethyl phosphate (TEP) solvent, and a fluoroethylene carbonate (FEC) co-solvent. By rationally tailoring the TEP/FEC ratio, the ternary phosphate electrolyte displays a well-balanced performance, not only enabling highly efficient sodium deposition (an average Coulombic efficiency of 95.7% for Na//Cu cells) but also inheriting the intrinsic anodic stability (≥4.5 V vs Na+/Na) and nonflammability of phosphates. As a consequence, high-voltage Na3V2(PO4)2F3 cathode-based sodium metal cells (Na3V2(PO4)2F3//Na) deliver remarkable cyclic stability (97.9% capacity retention after 300 cycles), which is among the best for Na3V2(PO4)2F3-based batteries. This work may guide the electrolyte design principles and is highly enlightening in developing high energy density sodium-based batteries.

Deep understanding of sustainable vanadium recovery from chrome vanadium slag: Promotive action of competitive chromium species for vanadium solvent extraction.

The complete separation of vanadium (V) and chromium (Cr) from chrome vanadium slag is still challenging. Many studies focus on the activity of vanadium, while the effect of the other element chromium and their mutual interaction are ignored. Here, we found that proper concentration of chromium can promote the extraction efficiency of vanadium. The extraction of V and Cr with various mass ratios ranging from 8:1-4:3 at different initial pH values using primary amine N1923 were studied. The extraction efficiency of V reached nearly 100%, while none of Cr was extracted when the mass ratio of Cr and V is 0.5 under proper pH. Through the dynamic monitoring of species evolutions during extraction, the transformation of the two metals and advantage extracted species were analyzed. Cr would transfer H+ for the combination of V3O93-/V4O124-, providing a great contribution to the continuous extraction of V. The real leachate was applied and 99.9% vanadium pentoxide was produced at a scale of 50 L/h. This paper offers deep insights of the separation of similar metal elements, and guide sustainable vanadium recovery from hazardous waste.

Wedge method for landfill stability analysis considering temperature increase.

The increase in landfill temperature often results in shear strength reduction of both the solid waste and the liner, which leads to slope instability. However, very few landfill slope analysis methods can simultaneously consider the effect of temperature on the shear strength of the waste solid and the liner. In this study, based on the strength parameters of the liner and waste with temperature, a wedge method for translational failure analysis of landfills considering temperature increase was established. The results showed that rising temperatures caused by biochemical degradation at the bottom and middle of the landfill reduced the anti-slide force of back slope more than that of bottom slope. With the leachate level increasing, the effect of temperature rise on landfill stability became obvious. The feasibility of the proposed wedge method was verified by the engineering case study of Xiaping Landfill, Shenzhen, China. This study probably provides important guidance for the design, operation and management of municipal solid waste landfills.

Electrolyte formulation strategies for potassium-based batteries.

Potassium (K)-based batteries are viewed as the most promising alternatives to lithium-based batteries, owing to their abundant potassium resource, lower redox potentials (-2.97 V vs. SHE), and low cost. Recently, significant achievements on electrode materials have boosted the development of potassium-based batteries. However, the poor interfacial compatibility between electrode and electrolyte hinders their practical. Hence, rational design of electrolyte/electrode interface by electrolytes is the key to develop K-based batteries. In this review, the principles for formulating organic electrolytes are comprehensively summarized. Then, recent progress of various liquid organic and solid-state K+ electrolytes for potassium-ion batteries and beyond are discussed. Finally, we offer the current challenges that need to be addressed for advanced K-based batteries.

Targeting lipid metabolism in multiple myeloma cells: Rational development of a synergistic strategy with proteasome inhibitors.

BACKGROUND AND PURPOSE: Aberrant lipid metabolism is recognized as a key feature of cancer cells. Our initial research on MS-based analysis of lipids in a multiple myeloma (MM) cell line showed a significant accumulation of lipids in multiple myeloma cells after proteasome inhibition. This finding prompted us to hypothesize that multiple myeloma cell survival depends on the maximal utilization of abnormally accumulated lipids. Therefore, we explored whether lipid metabolism-modulating agents would synergize with proteasome inhibitors. EXPERIMENTAL APPROACH: Lipid accumulation in multiple myeloma cells was measured by MS. Synergism between lipid regulators and proteasome inhibitors was assessed by cell viability and apoptosis. A novel stable derivative of fenofibrate (FCE) was synthesized and used to treat multiple myeloma cells in vitro and in vivo along with the proteasome inhibitor ixazomib. ChIP-seq, western blotting and RT-qPCR were performed to explore the potential mechanism(s) underlying the increase in lipid levels in multiple myeloma cells after proteasome inhibition. KEY RESULTS: Accumulation of lipids in multiple myeloma cells was induced by proteasome inhibition. Lipid-lowering drugs and MG-132 exerted a synergistic effect to kill multiple myeloma cells. FCE showed significant synergistic activity in vitro and in vivo with ixazomib. The abnormal lipid accumulation in multiple myeloma cells that was enhanced by proteasome inhibitors might be due to the elevated SREBP1/2 expression induced by ATF4. CONCLUSIONS AND IMPLICATIONS: Our results provide a proof of principle and support for the further clinical evaluation of the combination of lipid-modulating drugs with proteasome inhibitors in the treatment of multiple myeloma.

Uncovering LiH Triggered Thermal Runaway Mechanism of a High-Energy LiNi0.5 Co0.2 Mn0.3 O2 /Graphite Pouch Cell.

The continuous energy density increase of lithium ion batteries (LIBs) inevitably accompanies with the rising of safety concerns. Here, the thermal runaway characteristics of a high-energy 5 Ah LiNi0.5 Co0.2 Mn0.3 O2 /graphite pouch cell using a thermally stable dual-salt electrolyte are analyzed. The existence of LiH in the graphite anode side is innovatively identified in this study, and the LiH/electrolyte exothermic reactions and H2 migration from anode to cathode side are proved to contribute on triggering the thermal runaway of the pouch cell, while the phase transformation of lithiated graphite anode and the O2 -releasing from cathode are just accelerating factors for thermal runaway. In addition, heat determination during cycling at two boundary scenarios of adiabatic and isothermal environment clearly states the necessity of designing an efficient and smart battery thermal management system for avoiding heat accumulation. These findings will shed promising lights on thermal runaway route map depiction and thermal runaway prevention, as well as formulation of electrolyte for high energy safer LIBs.

Body mass index combined with waist circumference can predict moderate chronic kidney disease: A retrospective study.

ABSTRACT: Overweight and obesity may be associated with poor clinical outcome, including chronic kidney disease (CKD). However, whether body mass index (BMI), waist-to-hip ratio (WHR), and waist circumference (WC) are related to CKD is yet to be elucidated.A total of 7593 adults were divided into 4 groups based on the estimated glomerular filtration rate (eGFR) quartile. The eGFR was calculated with the CKD Epidemiology Collaboration. Multiple linear regression analyzed the association between eGFR and WHR, BMI, and WC. Logistic regression analysis determined whether the CKD patients were associated with WHR, BMI, and WC after adjusting for other variables.The mean age of the cohort was 72.34 ±â€Š7.30 years. Multiple linear regression analysis showed that WC (P = .006) was associated with eGFR, although adjusted by lifestyle factor and biochemical indicators. The individuals in the underweight, overweight, and obese groups had significantly lower eGFR value than those in the healthy weight group in moderate CKD. The eGFR in the overweight group with WHR ≤0.894 was higher than in the healthy weight group with WHR >0.894 group (P = .036). Overweight with WHR ≤0.894 group had a longer WC with a pronounced increase in the hip circumference. Logistic regression analysis showed that the WC (OR = 1.362, P < .001) and BMI (OR = 1.227, P = .031) were independent risk factors for moderate CKD patients. Each standard deviation (SD) of high BMI and WC level was associated with 23.0% and 17.3% higher odds of moderate CKD (OR = 1.230, P = .017 and OR = 1.173, P = .021, respectively).WC is an independent risk factor for eGFR. Combined BMI and WC are important factors that would predict moderate CKD patients.