Multi-omics in Spinal Cord Injury: Diagnosis, Prognosis, and Treatment.

A spinal cord injury (SCI) can result in varying degrees of limb movement impairment and sensory impairment, affecting the quality of life severely. The study of the molecular mechanisms underlying SCI disease has advanced greatly. However, there is still room for improvement in terms of the cognitive and systematic approaches used for disease diagnosis, progression, treatment, and prognosis. This situation might change as multi-omics technology advances. Single omics technology has some limitations when it comes to fully comprehending the disease progression pattern and directing SCI treatment. Therefore, a thorough understanding of the state of the art in omics research on SCI can explain the pathogenesis and mechanism of the disease and offer new, multifaceted treatments for SCI. This article reviews recent developments in the application of various omics techniques to diseases associated with SCI and discusses the advantages and disadvantages of using these techniques for disease diagnosis, prognosis, and treatment.

Evaluation of the effectiveness and safety of icariin in the treatment of knee osteoarthritis: A protocol for a systematic review and meta-analysis.

BACKGROUND: Knee osteoarthritis (KOA) is a chronic degenerative disease involving cartilage and surrounding tissues. It causes a huge burden to social and medical resources and seriously affects people's living and working ability. In recent years, people have become increasingly interested in the application of Chinese medicine monomers to treat KOA. Among them, icariin plays an important role in the clinical treatment of KOA. Therefore, to evaluate the effectiveness and safety of icariin in the treatment of KOA, we conducted this study to provide a new basis for the clinical treatment of KOA. METHODS: We propose a systematic search of the PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Wanfang, and China Biomedical databases for all randomized controlled trials examining the use of icariin in the treatment of KOA patients up to October 20, 2021. The screening and data extraction processes will be performed independently by 2 researchers. We will use the Cochrane risk bias assessment tool to evaluate the quality of the studies that met the inclusion criteria. The data will be statistically analyzed using RevMan5.3 software. RESULT: This study will provide high-quality evidence for the effectiveness and safety of icariin in the treatment of KOA. CONCLUSION: The purpose of this study was to explore the efficacy of icariin in the treatment of KOA and to provide clinicians and patients with new treatment strategies. INPLASY REGISTRATION NUMBER: INPLASY2021110015.

Efficient generation of a high-field terahertz pulse train in bulk lithium niobate crystals by optical rectification.

We demonstrate a highly efficient method for the generation of a high-field terahertz (THz) pulse train via optical rectification (OR) in congruent lithium niobate (LN) crystals driven by temporally shaped laser pulses. A narrowband THz pulse has been successfully achieved with sub-percent level conversion efficiency and multi MV/cm peak field at 0.26 THz. For the single-cycle THz generation, we achieved a THz pulse with 373-µJ energy in a LN crystal excited by a 100-mJ laser pulse at room temperature. The conversion efficiency is further improved to 0.77 % pumped by a 20-mJ laser pulse with a smaller pump beam size (6 mm in horizontal and 15 mm in vertical). This method holds great potential for generating mJ-level narrow-band THz pulse trains, which may have a major impact in mJ-scale applications like terahertz-based accelerators and light sources.