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1.
Ying Yong Sheng Tai Xue Bao ; 18(2): 371-5, 2007 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-17450742

RESUMO

With tomato variety "L402" as test crop, this paper studied its photosynthetic and transpiration characteristics in different seasons under different soil water contents. Three treatments were installed, i. e. , 80% ( I ) , 65% ( II ) and 50% ( III ) soil water content. The results showed that when cultivated in spring, the photosynthetic rate (Pn) and transpiration rate (Tr) of tomato leaves were the highest in treatment I , followed by treatments II and Ill, while the water utilization efficiency ( WUE) was the highest in treatment II. The decrease of soil water content changed the diurnal variations of Pn and Tr significantly, and aggravated the midday depression of photosynthesis. The tomato growing in winter had the lowest Pn and Tr in treatment mI , while no difference was observed between treatments I and II. No midday depression of photosynthesis was found among the three treatments. The WUE was the highest in treatment m , and the lowest in treatment I . All of these suggested that the tomato plants cultivated in different seasons had different responses to soil water content. The diurnal variations of their Pn and Tr were significantly different, and the Pn and Tr of spring tomato were significantly higher than those of winter tomato under the same soil water content.


Assuntos
Dióxido de Carbono/metabolismo , Fotossíntese/fisiologia , Solo/análise , Solanum lycopersicum/metabolismo , Água/metabolismo , Solanum lycopersicum/fisiologia , Folhas de Planta/metabolismo , Transpiração Vegetal , Estações do Ano , Água/análise
2.
Zhonghua Zhong Liu Za Zhi ; 28(1): 8-12, 2006 Jan.
Artigo em Chinês | MEDLINE | ID: mdl-16737611

RESUMO

OBJECTIVE: To investigate the sites and pattern of renal toxicity in rats treated with cisplatin and the protective effect of amifostine, and to understand whether Fas/FasL system is involved in cisplatin-induced nephrotoxicity. METHODS: Forty-eight Sprague-Dawley rats were randomly divided into 3 groups: control group (0.9% saline solution), cisplatin group (6 mg/kg) and amifostine group (cisplatin 6 mg/kg + amifostine 200 mg/kg). Serum BUN and creatinine were measured by automatic biochemiscal analysis. Renal histopathological lesions were examined by light microscopy. TUNEL method was used for counting apoptotic cells. Immunohistochemistry and image analysis system were used for observing the expression of Fas/FasL system in renal tissues. RESULTS: Compared with control group and amifostine group, serum BUN and creatinine were significantly elevated on day 3 (P < 0.05) and day 5 (P < 0.01 and P < 0.05, respectively), and recovered to normal on day 10. Severe necrosis and apoptosis of renal proximal tubular cells were revealed by elevated number of positively staining apoptotic cells examined by TUNEL method. Increased immunostaining intensity of Fas/FasL system in renal tissues in cisplatin-treated group was detected by immunohistochemistry and image analysis system. CONCLUSION: Amifostine can reduce cisplatin-induced nephrotoxicity and its mechanism is probably associated with the suppression of Fas/FasL expression in renal tissues.


Assuntos
Amifostina/farmacologia , Cisplatino/efeitos adversos , Túbulos Renais Proximais/patologia , Animais , Antineoplásicos/efeitos adversos , Apoptose/efeitos dos fármacos , Nitrogênio da Ureia Sanguínea , Creatinina/sangue , Proteína Ligante Fas/metabolismo , Túbulos Renais Proximais/metabolismo , Masculino , Necrose , Distribuição Aleatória , Ratos , Ratos Sprague-Dawley , Receptor fas/metabolismo
3.
Zhonghua Zhong Liu Za Zhi ; 28(10): 788-90, 2006 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-17366798

RESUMO

OBJECTIVE: To evaluate the efficacy and safety of modified FOLFIRI regimen in advanced colorectal cancer (CRC) patients refractory to fluoropyrimidine and oxaliplatin. METHODS: The modified FOLFIRI regimen consisted of intravenous infusion of irinotecan 180 mg/m2 d1 + LV 200 mg/m2 dl + 5-Fu 400 mg/m2 bolus dl plus 46-hour intravenous infusion of 5-Fu 2.4 g/m2, every 2 weeks as one cycle. The main selection criterion for this study was the advanced CRC refractory to fluoropyrimidine and oxaliplatin. RESULTS: Of the 80 evaluable patients for efficacy: 10 (12.5%) had a partial response, 51 (63.7%) stable disease, and 19 (23.8%) progressive disease. The median time to progression was 96 days. Safety analysis was based on the data of 83 evaluable patients. The most frequently observed grade 3 or 4 toxicities were neutropenia (24.1%), nausea/vomiting (8.4%), and diarrhea (2.4%). CONCLUSION: Modified FOLFIRI regimen is effective and well tolerated in patients with advanced colorectal cancer refractory to fluoropyrimidine and oxaliplatin.


Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Neoplasias do Colo/tratamento farmacológico , Neoplasias Retais/tratamento farmacológico , Adulto , Idoso , Antineoplásicos/uso terapêutico , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Camptotecina/efeitos adversos , Camptotecina/análogos & derivados , Camptotecina/uso terapêutico , Neoplasias do Colo/patologia , Diarreia/induzido quimicamente , Feminino , Fluoruracila/efeitos adversos , Fluoruracila/uso terapêutico , Humanos , Leucovorina/efeitos adversos , Leucovorina/uso terapêutico , Masculino , Pessoa de Meia-Idade , Náusea/induzido quimicamente , Estadiamento de Neoplasias , Neutropenia/induzido quimicamente , Compostos Organoplatínicos/uso terapêutico , Oxaliplatina , Estudos Prospectivos , Pirimidinas/uso terapêutico , Neoplasias Retais/patologia , Indução de Remissão , Falha de Tratamento
4.
Zhonghua Zhong Liu Za Zhi ; 27(6): 373-6, 2005 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-16117903

RESUMO

OBJECTIVE: This phase II clinical trial was designed to evaluate the efficacy and toxicity of recombinant human interleukin-11 (rhIL-11) derivative manufactured in China in the prevention and treatment of chemotherapy-induced thrombocytopenia in cancer patients. METHODS: A total of 100 cancer patients with chemotherapy-induced thrombocytopenia (< or = 75 x 10(9)/L) were studied by self-cross control. Ninty-one of them received 2 cycles of chemotherapy. In the first cycle (control cycle) the patients received chemotherapy only, while in the second cycle (treatment cycle), the patients were given subcutaneous injection of rhIL-11 derivative (40 microg.kg(-1).d(-1)) once daily after chemotherapy for 10 consecutive days or more until platelet count reached > or = 300 x 10(9)/L. RESULTS: 1. The patients with platelet count of < or = 75 x 10(9)/L was 89/89 in the control cycle and 44/89 in the treatment cycle (P = 0.00). The recovery time to the normal platelet count was 1-47 days (median 9 days) in the control cycle, and 1-18 days (median 5.5 days) in treatment cycle (P = 0.00). 2. Patients with platelet count of < or = 50 x 10(9)/L was 56/89 in the control cycle and 20/89 in the treatment cycle (P = 0.00). The recovery time to normal platelet count was 1-31 days (median 9 days) in the control cycle and 3-13 days (median 6 days) in the treatment cycle (P = 0.05). 3. The median nadir platelet count was 44 x 10(9)/L (range: 10 x 10(9)/L-75 x 10(9)/L) in the control cycle, and 83 x 10(9)/L (range: 10 x 10(9)/L-310 x 10(9)/L) in the treatment cycle (P = 0.00). The time of recovery to the normal platelet count was 1-31 days (median 6 days) in the control cycle, and 0-13 days (median 2 days) in the treatment cycle (P = 0.00). 4. Nine of 89 evaluable patients required platelet transfusion in the control cycle versus 1 of 89 patients in treatment cycle (P = 0.01), and the total platelet transfusion was 10 times in the control cycle versus once in the treatment cycle (P = 0.01). 5. The major adverse events associated with rhIL-11 derivative were: headache, fatigue, myalgia/arthralgia, edema and palpitation, etc. CONCLUSION: rhIL-11 derivative can be safely and effectively used for the prevention and treatment for chemotherapy-induced thrombocytopenia.


Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Neoplasias da Mama/tratamento farmacológico , Interleucina-11/administração & dosagem , Neoplasias Pulmonares/tratamento farmacológico , Trombocitopenia/tratamento farmacológico , Adulto , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , China , Feminino , Humanos , Injeções Subcutâneas , Interleucina-11/efeitos adversos , Linfoma/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Contagem de Plaquetas , Proteínas Recombinantes/administração & dosagem , Proteínas Recombinantes/efeitos adversos , Trombocitopenia/induzido quimicamente , Trombocitopenia/prevenção & controle
5.
Zhonghua Zhong Liu Za Zhi ; 25(6): 581-3, 2003 Nov.
Artigo em Chinês | MEDLINE | ID: mdl-14690567

RESUMO

OBJECTIVE: To observe the clinical efficacy and adverse effects of herceptin for advanced Chinese breast cancer patients. METHODS: Thirty-one pathologically proved advanced breast cancer women were treated by herceptin. In the first week, a loading dose 4 mg/kg was administered by intravenous infusion and from the second week, a routine dose of 2 mg/kg was given every week for at least 3 months. RESULTS: There were 2 CR, 6 PR, 7 SD, and 16 PD among 31 patients after treatment by herceptin, the response rate being 25.8%. In factors influencing the prognosis, age and general condition were factors favoring the results, and pathological type, site of metastasis, grade of her-2 over expression and prior treatment were irrelevant to the results. The adverse effects were mild but different from those of the common anticancer drugs. CONCLUSION: Herceptin is effective and well tolerated by the Chinese breast cancer patients.


Assuntos
Anticorpos Monoclonais/uso terapêutico , Neoplasias da Mama/tratamento farmacológico , Adulto , Idoso , Anticorpos Monoclonais/efeitos adversos , Anticorpos Monoclonais Humanizados , Feminino , Humanos , Pessoa de Meia-Idade , Trastuzumab
6.
Zhonghua Zhong Liu Za Zhi ; 25(6): 587-9, 2003 Nov.
Artigo em Chinês | MEDLINE | ID: mdl-14690569

RESUMO

OBJECTIVE: To evaluate the efficacy and toxicity of vinorelbine plus cisplatin in the treatment of advanced non-small cell lung cancer (NSCLC) previously treated with taxane-based chemotherapy. METHODS: Thirty patients (0 - 1 score ECOG performance status) with stage IIIB/IV NSCLC previously treated with taxane-based chemotherapy were eligible for the study. Fifteen patients received the regimen of vinorelbine plus cisplatin (NP), the others received mitomycin, vindesine plus cisplatin (MVP). RESULTS: The overall response rates were 13.3% in NP and 0 in MVP (P > 0.05). Time to progression was longer for NP patients than that for MVP ones (6 v 3 months, P < 0.05), so was median survival (9 v 6 months, P < 0.05). The 1-year survival rate of 40.0% in the NP group was significantly higher than that of 0 in MVP (P < 0.05). Grade III-IV toxicity was observed at a similar rate in both groups (P > 0.05), though both well tolerated. CONCLUSION: Regimen of vinorelbine plus cisplatin is appropriate for good performance status patients with advanced non-small cell lung cancer previously treated with taxane-based chemotherapy. Time to progression, median survival and 1-year survival are satisfactory in patients treated with NP, which is complicated with acceptable toxicity.


Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico , Cisplatino/administração & dosagem , Neoplasias Pulmonares/tratamento farmacológico , Vimblastina/análogos & derivados , Vimblastina/administração & dosagem , Adulto , Idoso , Carcinoma Pulmonar de Células não Pequenas/mortalidade , Cisplatino/efeitos adversos , Feminino , Humanos , Neoplasias Pulmonares/mortalidade , Masculino , Pessoa de Meia-Idade , Taxa de Sobrevida , Vimblastina/efeitos adversos , Vinorelbina
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