The expression of integrinbeta1 and FAK in pituitary adenomas and their correlation with invasiveness.

The expression and possible role of integrin-focal adhesion kinase signal pathway in invasive pituitary adenomas were explored. Forty-nine human pituitary adenomas were detected for the expression of integrinbeta1 (INTbeta1) and focal adhesion kinase (FAK) by immunohistochemistry, and their correlation with the invasiveness of pituitary adenomas as well as between themselves was analyzed. The results showed that INTbeta1 was expressed in 46 cases (93.9%) and FAK in 36 cases (73.5%), respectively, and their expression levels were highly correlated with tumor invasiveness, but not with the tumor types. It was suggested that the integrin-focal adhesion kinase signal pathway plays a role in the invasiveness of pituitary adenomas.

The Expression of Integrinβ1 and FAK in Pituitary Adenomas and Their Correlation with Invasiveness / 华中科技大学学报（医学）（英德文版）

Summary: The expression and possible role of integrin-focal adhesion kinase signal pathway in invasive pituitary adenomas were explored. Forty-nine human pituitary adenomas were detected for the expression of integrinβ1 (INTβ1) and focal adhesion kinase (FAK) by immunohistochemistry, and their correlation with the invasiveness of pituitary adenomas as well as between themselves was analyzed. The results showed that INTβ1 was expressed in 46 cases (93.9%) and FAK in 36 cases (73.5%), respectively, and their expression levels were highly correlated with tumor invasiveness, but not with the tumor types. It was suggested that the integrin-focal adhesion kinase signal pathway plays a role in the invasiveness of pituitary adenomas.

Conus medullaris schistosomiasis.

OBJECT: The authors performed a study to investigate the clinical manifestations, treatment strategies, and possible pathogenesis of conus medullaris schistosomiasis. METHODS: Six cases collected from the authors' experience and four cases reported in the literature were studied retrospectively for clinical manifestations, treatment outcomes, and prognosis. All patients experienced progressive lower-extremity weakness and functional bowel and bladder impairment. Although the magnetic resonance (MR) imaging results suggested the presence of a conus medullaris tumor, schistosomiasis was diagnosed based on pathological results obtained in the 10 patients. The results of surgery followed by pyquiton and hormone treatment confirmed the diagnosis, and the patients' prognoses were good. CONCLUSIONS: This pathological entity is predominantly found in adults, and the clinical manifestations have no specificity, although the MR imaging may provide some clues. As a form of ectopic schistosomiasis, conus medullaris schistosomiasis deserves special consideration and further exploration. If an early diagnosis can be made and pyquiton and hormone therapy is given, surgery can be avoided and the prognosis will remain good.

Basic fibroblast growth factor and fibroblast growth factor receptor-i in human meningiomas.

The expression of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor-1 (FGFR-1) in human meningiomas and the relationships between their expression and the tumors' histological features and angiogenesis were investigated by means of immunohistochemical technique. The expression of bFGF and FGFR-1 was detected by antibody of bFGF or FGFR-1. The tumors' angiogenesis was evaluated by microvascular density (MVD) and, which was observed by use of CD34-antibody immunohistochemically. The results showed that there were varied degrees of the expression of bFGF and FGFR-1 proteins in meningiomas. The expression was correlated with the tumors' histological characters and angiogenesis. It was concluded that bFGF and FGFR-1 might play important roles in meningiomas' angiogenesis and proliferation. The expression positive rate of bFGF and FGFR-1 may provide an indication of evaluating the histological and malignant degree of the tumor.

[Microecological distribution of toxin-producing bacteria in Fug rubripes in Bohai Sea and biological characteristics of B3B].

The study showed that toxin-producing bacteria were commonly existed in each part of Fugu rubripes body. 19 strains of high poisonous bacteria were isolated from its ovary, liver and other tissues, among which, strain B3B was identified as genus Bacillus based on its physiological and biochemical characteristics and 16SrDNA sequence, and could produce tetrodotoxin through mouse test, thinner chromatography, and mass spectrography.

[Research advances in plant growth-promoting rhizobacteria and its application prospects].

The study of plant growth-promoting rhizobacteria will provide possible methods to overcome the difficulties in controlling soil borne plant diseases. PGPR can colonize in rhizosphere at high population density, inhibit plant pathogens and deleterious microorganisms there, and promote crop growth and its yield. More importantly, some PGPR strains applied as biocontrol agents can make treated plant produce induced systemic resistance (ISR), and thus, increases plant overall health. In recent two decades, the researches of PGPR in abroad are very active, and many PGPR products have been applied successfully. In our contry, more attention should be paid to the study of the basic theory and application of GPPR and the industrialization of PGPR products.

Effect of thyrotropin-releasing hormone on cerebral free radical reactions following acute brain injury in rabbits.

OBJECTIVE: To investigate the early effect of thyrotropin-releasing hormone (TRH) on cerebral free radical reactions after acute brain injury in rabbits. METHODS: 30 healthy white rabbits were randomly divided into three groups: Group A (n=10), Group B (n=12) and Group C (n=8). The rabbits in Group A and Group B were injured by direct hit. At 0.5-4 hours after injury, the rabbits in Group A were injected with TRH (8 mg/kg body weight) through a vein and the rabbits in Group B were injected with normal saline of equal volume. The rabbits in Group C served as the normal control. Then all the rabbits were killed and brain tissues were obtained. The content of lipoperoxide (LPO), the activity of superoxide dismutase (SOD) and the water content of the brain tissues were measured. RESULTS: The contents of LPO and water in brain tissues in Group A were lower and the activity of SOD was higher than those of Group B (P<0.05). After injury, intracranial pressure (ICP) rose rapidly and continuously with time passing by. When TRH was given to the animals in Group A, the rising speed of ICP slowed down significantly. CONCLUSIONS: TRH can decrease the cerebral free radical reactions and cerebral edema after acute brain injury in rats.

[Bio-active substances derived from marine microorganisms].

Marine microorganisms, which are taxonomically diverse and genetically special, have powerful potential in producing novel bio-active substances. This article summarized research progress in this respect. The results showed that marine bacteria which are main marine microorganism flora can produce rich kinds of bio-active substances and that even though marine actinomycetes and marine fungi are not as many as marine bacteria in species and quantity, they should be paid no less attention about their bio-active substances. Besides, present research are limited to those marine microorganisms which are easily cultured. One of the future research trends will be focused on bio-active substances derived from non-culturable marine microorganisms.

[Obstacles of soybean continuous cropping, III. Mechanism of soybean yield increment by marine actinomyces MB-97].

An isolate of marine actinomyces MB-97 identified as Streptomyces microflavus could successfully colonize in the rhizoshpere of soybean, and inhibit Penicillium purpurogenum, a soybean deleterious rhizospheric microorganisms. After applied MB-97, the ratio of bacteria/fungi in the rhizosphere of soybean was increased, and the soil became to be "Bacterial type" from "Fungal type". The populations of P. purpurogenum were apparently suppressed about 80%, and the harm of toxins in soil was weak. The soybean root rot caused by soilborne fungi such as Fusarium was decreased 50%, and MB-97 could stimulate the growth of soybean seedlings. In field study, the mean yield of soybean raised by 15.2%, implying that Streptomyces microflavus was an effective plant growth-promoting rhizobacteria on soybean.