Effect of Topical and Intravenously Applied Tranexamic Acid Compared to Control Group on Bleeding in Primary Unilateral Total Knee Arthroplasty.

We aimed to answer the following three questions in this study: (1) Does tranexamic acid (TA) reduce the amount of bleeding in total knee arthroplasty (TKA)? (2) Does TA reduce requirement for blood transfusion? (3) Is there any difference on reliability and efficacy between topical and intravenous (IV) applications of TA? Patients were allocated into three groups randomly by a software program as topical, IV, and control group. TA was applied as 20 mg/kg to the IV group and as 3 g/100 mL saline to the topical group. The hemoglobin values were recorded preoperatively and postoperatively on the same day and on day 1 and day 2. Removal of the drain postoperatively and length of hospital stay, as well as any complications such as pulmonary embolism or deep venous thrombosis, were also noted. The study comprised 40 patients in the IV group, 42 in the topical group, and 41 in the control group. The drain output values were similar in the IV and topical groups (p = 0.161), while those of the control group were significantly higher than both the IV and topical groups (p < 0.001 and < 0.001). Transfusion was applied to 19.5% of cases in the control group, 4.8% in the topical group, and 5.1% of the IV group (χ2 = 6.522; p = 0.038). The results of the study showed that 20 mg/kg single-dose IV bolus or 3 g topical TA application reduced blood loss and transfusion requirement without increasing the rate of thromboembolic complications in unilateral primary TKA.

Posterior bone block of chronic locked posterior shoulder dislocations with glenoid augmentation: a retrospective evaluation of ten shoulders.

PURPOSE: The aim of this study, which is the most extensive series to date on this subject, was to present the results of ten shoulders of seven patients treated with the posterior bone block augmentation method with autograft taken from the iliac wing for a chronic locked posterior shoulder dislocation and to evaluate the results in the light of the relevant literature. METHODS: A retrospective examination was made of patients who underwent iliac autograft with glenoid augmentation for chronic posterior shoulder dislocation in our clinic between 2004 and 2011. All of the patients had been initially treated at another centre and referred to our hospital because of continuing or relapsing posterior shoulder dislocation. Assessment was made by physical examination X-ray, computed tomography (CT), and the Constant-Murley score. RESULTS: All the patients were male with a mean age at the time of surgery of 42.4 years (range, 23-53 years), with a mean follow-up period of 40.6 months (range, 24-55 months). On presentation, all the patients had locked posterior shoulder dislocation. Radiological union was evaluated from the CT images taken 24 months postoperatively. The graft was observed to have been incorporated in all cases. The mean postoperative Constant-Murley score was 81.25/100 ± 17.8. In seven of the shoulders, arthropathy findings increased by varying degrees. CONCLUSIONS: A functional and stable shoulder can be obtained with glenoid augmentation in patients with chronic locked posterior shoulder dislocation. When other treatment alternatives are considered for a young patient group, this is a safe and applicable treatment method.