Exploring novel electroanalytical approach using MWCNT nanostructures to quantify nimodipine.

A new type of buckypaper of MWCNT with entrapped Nimodipine (NMD) drug was constructed. NMD features a nitroaromatic group that is electroreducible, and a dihydropyridine ring that can be electrooxidized. From the perspective of the nitroaromatic group's reductive capability, we have devised amperometric and voltammetric analytical strategies, including both differential pulse and linear voltammetric techniques. These methods are implemented using glassy carbon electrodes (GCE) modified with buckypaper (BP) disks composed of multiwalled carbon nanotubes (MWCNT), which are capable of adsorbing NMD. Furthermore, by capitalizing on the oxidative capacity of the dihydropyridine ring, we have designed strategies that involve amperometry using screen-printed electrodes (SPE) modified with BP-MWCNT mini discs within a Batch Injection Analysis Cell (BIAS) designed for SPE. The developed sensor was applied successfully to determine the drug in commercial tablets. The analytical parameters of this sensor were adequate, with a recovery value of 98.24 % and detection and quantification limits of 7.01 mgL-1 and 23.35 mgL-1, respectively using the DPV method.

Effects of Propolis on Infectious Diseases of Medical Relevance.

Infectious diseases are a significant problem affecting the public health and economic stability of societies all over the world. Treatment is available for most of these diseases; however, many pathogens have developed resistance to drugs, necessitating the development of new therapies with chemical agents, which can have serious side effects and high toxicity. In addition, the severity and aggressiveness of emerging and re-emerging diseases, such as pandemics caused by viral agents, have led to the priority of investigating new therapies to complement the treatment of different infectious diseases. Alternative and complementary medicine is widely used throughout the world due to its low cost and easy access and has been shown to provide a wide repertoire of options for the treatment of various conditions. In this work, we address the relevance of the effects of propolis on the causal pathogens of the main infectious diseases with medical relevance; the existing compiled information shows that propolis has effects on Gram-positive and Gram-negative bacteria, fungi, protozoan parasites and helminths, and viruses; however, challenges remain, such as the assessment of their effects in clinical studies for adequate and safe use.

Participación de residentes de cirugía plástica de Chile en la publicación científica: revisión de los últimos 20 años / Participation of chilean plastic surgery residents in scientific publications: review of the last 20 years

Resumen Objetivo: Analizar la participación de los residentes de cirugía plástica de Chile en la publicación científica de los últimos 20 años y evaluar su experiencia durante la residencia. Materiales y Método: Revisión de la literatura desde 1998-2018 bajo los términos: Cirugía Plástica, Plastic Surgery y Chile. Se incluyeron aquellos con al menos un autor cirujano plástico con filiación en Chile. Se registró la participación reportada de residentes y analizaron sus autores según su período de residencia y fecha de publicación, agregándolos como residentes no reportados. Se analizó tema, año de publicación y revista. Se aplicó una encuesta a residentes de cirugía plástica y postbecados recientes para conocer la percepción sobre su participación en actividades científicas. Se comparó la participación entre residentes con y sin año de investigación mediante el test exacto de Fisher. Resultados: Predominó la temática reconstructiva (48,2%), en adultos (68,6%) y en centros universitarios (48,7%). La participación reportada de residentes fue de 8,4%, subiendo a 38,2% al ampliarla a los no explicitados como residentes. Los encuestados expusieron la falta de tiempo como principal impedimento a la publicación y participación en congresos. Discusión: La participación en actividades científicas resulta beneficiosa para residentes, sus tutores y la reputación académica de sus centros. La mayoría de los residentes cree que su participación podría haber sido mayor en caso de que se hubiesen dado más facilidades. Conclusiones: La participación de residentes de cirugía plástica se encuentra subreportada. Programas de investigación, tiempos protegidos y mayor tutorización podrían aumentar esta cifra.

Aim: Evalúate the participation of Chilean plastic surgery residents in scientific publication in the last 20 years and assess their experience during residency. Materials and Method: Literature review from 1998-2018 under the terms: Cirugia Plastica AND Plastic Surgery AND Chile. Publications with at least one plastic surgeon author with filiation reported in Chile were considered. Those with reported participation of residents were registered and their authors were also analyzed according to their period of residence and date of publication, adding them as unreported residents. Subjects, year of publication and journals were analyzed. A survey was applied to plastic surgery residents and recent plastic surgery graduates to evaluate the perception of their participation in scientific activities. Residents participation with and without a previous research fellow was compared using Fisher's exact test. Results: Reconstructive themed studies (48.2%), in adults (68.6%) and in university centers (48.7%) prevailed among the included articles. The reported participation of residents was 8.4%, which rised to 38.2% when it was extended to those not explicitly reported as residents among the authors. Residents exposed the lack of time as the main barrier to publication and congress participations. Discussion: Participation in scientific activities is beneficial for residents, their mentors and the academic reputation of their centers. The majority of residents believe that their participation could have been greater if more facilities had been given. Conclusions: Participation of plastic surgery residents in scientific publications is under reported. The implementation of research programs, protected times and active mentoring could increase this number.

Biomedical Properties of Propolis on Diverse Chronic Diseases and Its Potential Applications and Health Benefits.

The use of alternative medicine products has increased tremendously in recent decades and it is estimated that approximately 80% of patients globally depend on them for some part of their primary health care. Propolis is a beekeeping product widely used in alternative medicine. It is a natural resinous product that bees collect from various plants and mix with beeswax and salivary enzymes and comprises a complex mixture of compounds. Various biomedical properties of propolis have been studied and reported in infectious and non-infectious diseases. However, the pharmacological activity and chemical composition of propolis is highly variable depending on its geographical origin, so it is important to describe and study the biomedical properties of propolis from different geographic regions. A number of chronic diseases, such as diabetes, obesity, and cancer, are the leading causes of global mortality, generating significant economic losses in many countries. In this review, we focus on compiling relevant information about propolis research related to diabetes, obesity, and cancer. The study of propolis could generate both new and accessible alternatives for the treatment of various diseases and will help to effectively evaluate the safety of its use.

The immune response of the scallop Argopecten purpuratus is associated with changes in the host microbiota structure and diversity.

All organisms live in close association with a variety of microorganisms called microbiota. Furthermore, several studies support a fundamental role of the microbiota on the host health and homeostasis. In this context, the aim of this work was to determine the structure and diversity of the microbiota associated with the scallop Argopecten purpuratus, and to assess changes in community composition and diversity during the host immune response. To do this, adult scallops were immune challenged and sampled after 24 and 48 h. Activation of the immune response was established by transcript overexpression of several scallop immune response genes in hemocytes and gills, and confirmed by protein detection of the antimicrobial peptide big defensin in gills of Vibrio-injected scallops at 24 h post-challenge. Then, the major bacterial community profile present in individual scallops was assessed by denaturing gradient gel electrophoresis (DGGE) of 16S rDNA genes and dendrogram analyses, which indicated a clear clade differentiation of the bacterial communities noticeable at 48 h post-challenge. Finally, the microbiota structure and diversity from pools of scallops were characterized using 16S deep amplicon sequencing. The results revealed an overall modulation of the microbiota abundance and diversity according to scallop immune status, allowing for prediction of some changes in the functional potential of the microbial community. Overall, the present study showed that changes in the structure and diversity of bacterial communities associated with the scallop A. purpuratus are detected after the activation of the host immune response. Now, the relevance of microbial balance disruption in the immune capacity of the scallop remains to be elucidated.

Efecto del uso intraoperatorio de corticoides en dosis bajas en pacientes sometidos a resección hepática mayor con maniobra de Pringle / Effects of low dose corticosteroids in patients undergoing major hepatic resection with Pringle maneuver

Introducción: Las resecciones hepáticas mayores pueden presentar una alta morbimortalidad en relación al sangrado intraoperatorio. La utilización de la maniobra de Pringle permite disminuir esta complicación a costa de un daño por isquemia-reperfusión. Una estrategia para minimizarla es el uso de corticoides perioperatorios. Objetivo: Evaluar el uso de metilprednisolona en dosis bajas (< 500 mg) en pacientes sometidos a resección hepática mayor con maniobra de Pringle en la incidencia de daño por isquemiareperfusión, morbilidad y mortalidad perioperatoria. Material y Métodos: Estudio retrospectivo utilizando la base de datos de hepatectomías entre los años 2000 y 2015. De un total de 171 resecciones hepáticas mayores, 62 utilizaron clampeo vascular. Se establecieron dos grupos: (A) aquellos que recibieron metilprednisolona inmediatamente previo al clampeo (n = 27) y (B) pacientes sin metilprednisolona (n = 35). Se evaluó el daño por isquemia-reperfusión por alteración de las pruebas hepáticas en los días 1, 3 y 5. Resultados: Los pacientes del grupo A tuvieron mayor tiempo de isquemia (43 + 3,3 vs 27 + 2,1 min, p < 0,05) que el grupo B, con una significativamente menor elevación de las fosfatasas alcalinas y bilirrubina en los días 1 y 5 poshepatectomía. No se observó diferencias en la magnitud del sangrado y no hubo diferencias en morbimortalidad. Conclusiones: La utilización de dosis bajas de metilprednisolona parece disminuir el impacto del DIR relacionado a la resección hepática bajo clampeo vascular, evitando los efectos adversos de la administración de esteroides en dosis altas.

Introduction: Liver resections may be associated with high morbidity and mortality due to intraoperative bleeding. Pringle maneuver reduces this complication at the expense of ischemia-reperfusion injury. Current strategies to minimize reperfusion injury include the use of perioperative corticosteroids. Objective: To assess the use of methylprednisolone in low doses (< 500 mg) in patients submitted to major hepatic resection under Pringle maneuver in the incidence of ischemia-reperfusion injury, peri-operative morbidity, and mortality. Material and Methods: Retrospective study from the liver resections database undertaken between the years 2000-2015 in our center. One hundred and seventy-one major liver resections were done, in 62 under Pringle maneuver. Two groups were established: (A) Patients administered methylprednisolone immediately before Pringle maneuver (n = 27) and (B) those without steroid (n = 35). We assessed ischemia-reperfusion injury by measuring liver tests on days 1, 3 and 5. Results: Patients in group A had longer ischemia time (43 ± 3.3 vs. 27 ± 2.1 min, p < 0.05) than those of group B, and significantly lower elevation of serum phosphatase alkaline and bilirubin on days 1 and five post-hepatectomy. We did not observe any difference in bleeding magnitude, and there were no differences in morbidity or mortality. Conclusions: The use of low doses of methylprednisolone seems to diminish the impact of ischemia-reperfusion injury related to major hepatic resection under Pringle maneuver avoiding the adverse side effects of high dose steroid.

Intervención cognitivo-conductual para trastornos del sueño en adultos mayores / Cognitive-behavioral intervention on senior adults with sleep disorders / Intervenção cognitivo-comportamental para transtornos do sono em idosos

Los trastornos del sueño en el adulto mayor son un problema manifestado con frecuencia, que afecta la calidad de vida y tiene impacto en los costos y el cuidado de salud. La actual forma de manejo de estos problemas se relaciona con prescripciones de fármacos, los cuales tienen efectos secundarios y aumenta su vulnerabilidad. En este contexto, el objetivo de esta investigación es evaluar la efectividad de una intervención cognitivo y conductual, que pretende mejorar el sueño mediante el cambio de los hábitos deficientes, así como el desafío de los pensamientos, las actitudes y las creencias negativas acerca del mismo. El método incluyó intervenciones cognitivo-conductuales grupales, con evaluaciones pre y post intervención. Los resultados indican una media de 9 (Pittsburgh) al inicio del programa y 4.9 al finalizar. Se concluye que la intervención a corto plazo consigue cambios significativos en hábitos e higiene del sueño. Esta investigación orienta a los profesionales de enfermería en la aplicación de estrategias hacia el bienestar del adulto mayor y el desarrollo de la disciplina en el marco del fortalecimiento de cuidados esenciales y fundamentales en procesos vitales.

Sleep disorders among senior adults are a frequent problem which has important impacts on their quality of life, and the costs of healthcare. The current management of these disorders is based on drug prescriptions, which in turn, have secondary effects and also enhance underlying conditions and vulnerabilities. Within this context, the objective of this study was to assess the effectiveness of a cognitive behavioral intervention aimed at improving the quality of sleep of these persons by modifying negative habits, thoughts, and beliefs. The method included group cognitive-behavioral interventions with pre and post assessments. The corresponding results showed a mean of 9 (Pittsburg) at the beginning of the program, and a mean of 4.9 at the end. It was thus concluded that the intervention, in the short term, helped to achieve significant improvements in relation to the sleep hygiene of these persons. This study can orient nursing professionals to establish strategies aimed at the wellbeing of senior adults; all within the vital processes and essential care strengthening framework.

Os transtornos do sono no idoso são um problema manifestado com frequência e que afeta a qualidade de vida e tem impacto nos custos e no cuidado de saúde. A atual forma de manejo destes problemas relaciona-se com prescrições de fármacos, os quais têm efeitos secundários e aumenta sua vulnerabilidade. Neste contexto, o objetivo desta pesquisa é avaliar a efetividade de uma intervenção cognitivo e comportamental, que pretende melhorar o sono mediante a mudança dos hábitos deficientes, assim como o desafio dos pensamentos, as atitudes e as crenças negativas acerca de si próprio. O método incluiu intervenções cognitivo-comportamentais grupais, com avaliações pre e post intervenção. Os resultados indicam uma média de 9 (Pittsburg) ao início do programa e 4.9 para finalizar. Conclui-se que a intervenção a curto prazo consegue câmbios significativos em hábitos e higiene do sono. Esta pesquisa orienta aos profissionais de enfermagem na aplicação de estratégias para o bem-estar do idoso e do desenvolvimento da disciplina no marco do fortalecimento de cuidados essenciais e fundamentais em processos vitais.

Alternativas de cierre de fasciotomías en extremidades / Alternatives for the closure of extremity fasciotomy

Resumen La fasciotomía es el pilar del tratamiento y prevención del síndrome compartimental agudo. Una vez resuelto el cuadro agudo que derivó en la necesidad de ésta, el cierre de la herida resultante genera un importante desafío reconstructivo para el cirujano dado el importante edema residual de los tejidos. El objetivo de este artículo es entregar una actualización respecto a las alternativas de cierre de una fasciotomía de extremidades, para lo cual se realizó una búsqueda de artículos indexados en PubMed, Epistemonikos y Scielo. Se encontraron al menos 6 técnicas disponibles, cada una de ellas con determinadas ventajas y desventajas. Recomendamos que la elección sea de acuerdo a la experiencia del cirujano, los recursos disponibles y el contexto de cada paciente.

Fasciotomy is the mainstay of treatment and prevention of acute compartment syndrome. Given the important deep tissue edema, closure of the resulting wound generates a significant reconstructive challenge for the surgeon. The aim of this article is to provide an update concerning alternatives for closure of fasciotomy of limbs, for which a search of articles indexed in PubMed, Scielo and Epistemonikos databases was performed. At least 6 techniques were found, each of them with specific advantages and disadvantages. We recommend that the choice should be according to the surgeons experience, resources and context of each patient.

Anti-Candida Activity of Bursera morelensis Ramirez Essential Oil and Two Compounds, α-Pinene and γ-Terpinene-An In Vitro Study.

The candidiasis caused by C. albicans is a public health problem. The abuse of antifungals has contributed to the development of resistance. B. morelensis has demonstrated antibacterial and antifungal activities. In this work the activity of the essential oil of B. morelensis was evaluated and for its two pure compounds with analysis of the different mechanisms of pathogenesis important for C. albicans. The essential oil was obtained by the hydro-distillation method and analyzed using GC-MS. The anti-Candida activity was compared between to essential oil, α-Pinene and γ-Terpinene. GC-MS of the essential oil demonstrated the presence of 13 compounds. The essential oil showed antifungal activity against four C. albicans strains. The most sensitive strain was C. albicans 14065 (MFC 2.0 mg/mL and MIC50 0.125 mg/mL) with α-Pinene and γ-Terpinene having MFCs of 4.0 and 16.0 mg/mL respectively. The essential oil inhibited the growth of the germ tube in 87.94% (8.0 mg/mL). Furthermore, it was observed that the essential oil diminishes the transcription of the gene INT1. This work provides evidence that confirms the anti-Candida activity of the B. morelensis essential oil and its effect on the growth of the germ tube and transcription of the gene INT1.

Polymorphisms FTO rs9939609, PPARG rs1801282 and ADIPOQ rs4632532 and rs182052 but not lifestyle are associated with obesity related-traits in Mexican children.

Concerning the genetic factors of obesity, no consistent association between populations has been reported, which may be due to the frequency of polymorphisms, the lifestyle of studied populations and its interaction with other factors. We studied a possible association of polymorphisms FTO rs9939609, PPARG rs1801282, and ADIPOQ rs4632532 and rs182052 with obesity phenotypes in 215 Mexican children. Glucose, triglycerides, cholesterol, HDL and LDL were measured. In addition, weight, height, waist circumference and triceps skin thickness were recorded. High-energy diets and sedentary behavior were evaluated with a validated questionnaire. In contrast with other reports, only FTO rs9939609 was associated with obesity related-traits, including BMI (p = 0.03), waist circumference (p = 0.02), triceps skinfold (p = 0.03) and waist/height ratio (p = 0.01), and also with cholesterol levels (p = 0.02) and LDL (p = 0.009). Lower levels of triglycerides (p=0.04) were related with presence of PPARG rs1801282, while ADIPOQ rs4632532 showed an effect on HDL (p = 0.03) levels. On the other hand, diet, physical activity and screen time were not related with obesity. In summary, only FTO rs9939609 was associated with obesity related-traits, while PPARG2 rs1801282 and ADIPOQ rs4632532 were involved in lipid metabolism.

Environmental exposure to arsenic and chromium in children is associated with kidney injury molecule-1.

Environmental hazards from natural or anthropological sources are widespread, especially in the north-central region of Mexico. Children represent a susceptible population due to their unique routes of exposure and special vulnerabilities. In this study we evaluated the association of exposure to environmental kidney toxicants with kidney injury biomarkers in children living in San Luis Potosi (SLP), Mexico. A cross-sectional study was conducted with 83 children (5-12 years of age) residents of Villa de Reyes, SLP. Exposure to arsenic, cadmium, chromium, fluoride and lead was assessed in urine, blood and drinking water samples. Almost all tap and well water samples had levels of arsenic (81.5%) and fluoride (100%) above the permissible levels recommended by the World Health Organization. Mean urine arsenic (45.6ppb) and chromium (61.7ppb) were higher than the biological exposure index, a reference value in occupational settings. Using multivariate adjusted models, we found a dose-dependent association between kidney injury molecule-1 (KIM-1) across chromium exposure tertiles [(T1: reference, T2: 467pg/mL; T3: 615pg/mL) (p-trend=0.001)]. Chromium upper tertile was also associated with higher urinary miR-200c (500 copies/µl) and miR-423 (189 copies/µL). Arsenic upper tertile was also associated with higher urinary KIM-1 (372pg/mL). Other kidney injury/functional biomarkers such as serum creatinine, glomerular filtration rate, albuminuria, neutrophil gelatinase-associated lipocalin and miR-21 did not show any association with arsenic, chromium or any of the other toxicants evaluated. We conclude that KIM-1 might serve as a sensitive biomarker to screen children for kidney damage induced by environmental toxic agents.

Pollen:ovule ratio and its relationship with other floral traits in Papilionoideae (Leguminosae): an evaluation with Argentine species.

The pollen:ovule ratio (P/O) has traditionally been used as a rough estimator of plant breeding systems. It has been shown that plant breeding systems are associated with particular floral traits. In this study, we determined the P/O in 21 Leguminosae species from Argentina and explored relationships between P/O and taxonomic position, flower size, floral rewards, pollen presentation and pollination mechanisms. According to the results, 15 out of the 21 species classified were obligate xenogamous, although some of them have been recorded as facultative xenogamous in previous studies. There was a significant effect of taxonomic position (genus), reward type and pollination mechanism on P/O. Species offering only nectar as a floral reward (which were species with a brush mechanism) had a significantly lower P/O than species offering pollen or pollen and nectar. Species with the brush pollination mechanism had the lowest P/O, while species with valvular and pump mechanism had the highest P/O. However, pollen presentation (primary and secondary) and flower size did not have a significant effect on P/O. Our results demonstrate that P/O variability is determined by taxonomic position and pollination mechanism in this plant group.

[Psychologica well-being, perceived organizational support and job satisfaction amongst Chilean prison employees]. / Bienestar psicológico, apoyo organizacional percibido y satisfacción laboral en funcionarios penitenciarios de Chile.

This research aims to identify the relationship between job satisfaction, psychological well-being and Perceived Organizational Support amongst prison officials. 190 officials working in one state prison and one privately-run prison were evaluated using the Job Satisfaction Questionnaire¹, Psychological Well-being Scale² and Scale of Perceived Organizational Support³. The main results show a significant positive correlation between job satisfaction, psychological well-being and perceived organizational support, so that those who are satisfied with their jobs tend to feel better psychologically and perceive that they receive support from their organizations. Furthermore the study variables showed no significant differences between officials at both prisons. As regards socio-demographic figures, gender differences were found in terms of job satisfaction and psychological well-being, while no differences were found according to unit.

Valor diagnóstico de punción aspirativa con aguja fina en nódulo tiroideo: hospital Doctor Gustavo Fricke / Diagnostic value of puncture aspiration with fine needle in thyroide nodule: hospital Doctor Gustavo Fricke

Introducción: la punción aspirativa con aguja fina (PAAF) ha ido introduciéndose paulatinamente en la práctica clínica y constituye actualmente el método de elección en la aproximación diagnóstica del cáncer tiroideo. La PAAF ha contribuido a reducir el porcentaje de pacientes tiroidectomizados, 67 aumentando la cirugía por cáncer tiroideo del l5 porciento al 39 porciento. Objetivo: determinar el Valor diagnóstico de la PAAF en pacientes sometidos a tiroidectomía en el Hospital Doctor Gustavo Fricke (HGF), entre los71 años 2006-2007. Material y Método: estudio observacional descriptivo retrospectivo. Se utilizó el registro de pacientes sometidos a procedimiento quirúrgico por nódulo tiroideo, que hayan sido previamente estudiados con PAAF en policlínico de Endocrinología del HGF. Resultados: el valor diagnóstico de la PAAF, en el estudio pre-operatorio del nódulo tiroideo y su relación con la biopsia definitiva postoperatoria, alcanzó una sensibilidad de 7l porciento y una especificidad del 54,S porciento. Discusión: el rendimiento que alcanzó la PAAF de los nódulos tiroideos para excluir o confirmar carcinoma tiroideo fueron bajos en relación a estudios internacionales que poseen una sensibilidad del 83 porciento y una especificidad del 92 porciento.

Introduction: the flne-needle aspiration (FNA) has been gradually incorporated into the clinical practice and nowadays represents the method of choice in the diagnosis of the thyroid cancer. The FNA has helped to reduce the percentage of patients that undergo thyroidectomy, and it has increased the operation for thyroid cancer from 15 percent to 39 percent. Objetive: establish the diagnostic value ofthe FNA in patients submitted to thyroidectomy in Hospital Doctor Gustavo Fricke (HGF), between 2006 and 2007. Materials and Methods: this is a descriptive observational retrospective study. We used a register of patients submitted to surgical procedure for thyroid nodule that also have been studied with FNA in the clinic of Endocrinology of the HGF. Results: the diagnostic value of FNA in the preoperative study of the thyroid nodule and its relationship with the definitive surgical biopsy reaches a sensibility of 71 percent and a specificity of S4,8 percent. Discussion: the thyroid nodules FNA had a low performance for exclude or confirm thyroid carcinoma in thyroid nodules compared to international studies (sensibility 83 percent and specificity 92 percent).

Ocurrencia de escorpionismo en los distritos sanitarios del estado Mérida Venezuela / Ocurrence of scorpionism in sanitary districs of Mérida state Venezuela

Los accidentes escorpiónicos que involucran al género Tityus son la causa más común de los envenenamientos ocurridos en el Estado Mérida. Para estudiar la ocurrencia de estos accidentes de acuerdo a los distritos sanitarios del Estado, se evaluaron el registro de morbilidad mensual EP115 y mortalidad EP113, y la memoria y cuenta de la Coordinación de Epidemiología del Estado Mérida; los años revisados comprenden desde 1994 hasta 2003. En los reportes, se detectó que la mayoría de los accidentes ocurrieron en los distritos sanitarios de Mérida, Tovar y El Vigía. Sin embargo, las muertes registradas (11) ocurrieron en niños con edades iguales o menores a los 9 años y en los distritos sanitarios de Tovar y El Vigía, lo que hace suponer que pudieron ser ocasionadas por la especie Tityus zulianus, que es la más abundante en la zona.

Structural effects on the reactivity 1,4-dihydropyridines with alkylperoxyl radicals and ABTS radical cation.

A series of eight commercial C-4 substituted 1,4-dihydropyridines and other synthesized related compounds were tested for direct potential scavenger effect towards alkylperoxyl radicals and ABTS radical cation in aqueous Britton-Robinson buffer pH7.4. A direct quenching radical species was established. The tested 1,4-dihydropyridines were 8.3-fold more reactive towards alkylperoxyl radicals than ABTS cation radical, expressed by their corresponding kinetic rate constants. Furthermore, NPD a photolyte of nifedipine and the C-4 unsubstituted 1,4-DHP were the most reactive derivatives towards alkylperoxyl radicals. The pyridine derivative was confirmed by GC/MS technique as the final product of reaction. In consequence, the reduction of alkylperoxyl and ABTS radicals by 1,4-dihydropyridines involved an electron transfer process. Also, the participation of the hydrogen of the 1-position appears as relevant on the reactivity. Results of reactivity were compared with Trolox.