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1.
Langenbecks Arch Surg ; 408(1): 312, 2023 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-37581699

RESUMO

INTRODUCTION: In esthetic surgery, the use of silicone implants is a topic of hot discussion. MATERIAL AND METHODS: An analysis of 119 esthetic surgical interventions on the mammary gland was performed. A study of the immune and endocrine parameters after mammoplasty was carried out. RESULTS: The phenomenon of an increase in the levels of autoantibodies to the TSH receptor was revealed. The phenomenon of pre-operative growth of prolactin and TSH levels has been confirmed. An increase in thyroid autoimmunity after silicone mammoplasty is interpreted as a result of a silicone adjuvant action. An increase in the incidence of ASIA syndrome in patients who underwent breast surgery was registered. However, it was observed in both patients with silicone and non-silicone breast surgeries and therefore could not be solely explained by the use of silicone. Within 12 months following silicone mammoplasty, the patients with an increase of anti-TSH receptor autoimmunity nevertheless did not show any clinical and laboratory signs of overt thyroid disease, thus staying in a pre-nosological state. PRACTICAL RECOMMENDATIONS: Based on these results, we recommend the following for esthetic surgery: (a) all patients planned for silicone implant surgery should be examined for autoantibodies to the TSH receptor and (b) patients who have undergone breast endoprosthesis, starting 6 months after the operation, need long-term follow-up for thyroid status with mandatory testing for the level of these autoantibodies.


Assuntos
Autoimunidade , Implantes de Mama , Humanos , Silicones/efeitos adversos , Implantes de Mama/efeitos adversos , Glândula Tireoide , Autoanticorpos
2.
Tuberculosis (Edinb) ; 134: 102202, 2022 05.
Artigo em Inglês | MEDLINE | ID: mdl-35430551

RESUMO

Despite the proven infectious nature of tuberculosis, new data have recently appeared on the autoimmune component in the course of tuberculosis infection. This chapter discusses the currently known signs of autoimmune inflammation in tuberculosis infection, including both clinical and immunological manifestations. Taking into account the available data on the possible triggering effect of M. tuberculosis on the development of the autoimmune process, the correction of these autoimmune complications may be a key moment in prescribing therapy and in predicting the low efficacy of the treatment of the disease.


Assuntos
Doenças Autoimunes , Mycobacterium tuberculosis , Tuberculose , Autoanticorpos , Doenças Autoimunes/complicações , Doenças Autoimunes/tratamento farmacológico , Autoimunidade , Humanos , Inflamação , Tuberculose/diagnóstico , Tuberculose/tratamento farmacológico , Tuberculose/epidemiologia
3.
Int J Circumpolar Health ; 80(1): 1966924, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34406108

RESUMO

The study is aimed to evaluate the HIV, TB, and HIV/TB coinfection incidence per 100,000 population/year in Russian Arctic, based on official statistical data. The epidemics' incidence in Russian Arctic is uneven. The highest HIV incidence in 2019 was registered in Krasnoyarsk region (94,6), and the highest TB incidence in ChAD (136,1). ChAD was also identified as the region with the worst indicators, where the HIV incidence in 2007-2019 was evaluated at (315,8%), TB (136,1%), HIV/TB coinfection (150,0%). Despite the significant reduction in TB incidence in Arkhangelsk oblast (-63,9%), Karelia (-57,3%) and Komi (-56,2%) republics, it is alarming to observe dramatic increases in HIV incidence in the aforementioned regions (592,3%, 331,8%, 156,5% respectively). External factors influence HIV and TB incidence in most regions. Prevailing in men, HIV and TB incidence disparities between the general population and permanent residents occurred in all regions, except in ChAD and NAD, where the infections were diagnosed only among permanent residents. It is necessary to provide more detailed studies focusing on HIV, TB, and HIV/TB coinfection features in each circumpolar district in order to determine the main risk factors, especially among indigenous peoples as a vulnerable group, and to evaluate the HIV/TB collaborative services' capacity.


Assuntos
Coinfecção , Infecções por HIV , Regiões Árticas , Coinfecção/epidemiologia , Infecções por HIV/epidemiologia , Humanos , Incidência , Masculino , Federação Russa/epidemiologia
4.
Clin Immunol ; 227: 108724, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-33845192

RESUMO

Sarcoidosis and tuberculosis have many clinical and laboratory similarities, which allowed researchers to assume the presence of common pathogenetic mechanisms in the development of both diseases. Recently, much attention has been paid to investigate the autoimmune origins in these pathologies. The aim of this study is to find out the characteristics of the autoinflammatory immune response in sarcoidosis and tuberculosis. In patients with sarcoidosis (n = 93), tuberculosis (n = 28), and in healthy donors (n = 40), the serum anti-MCV concentration was measured by ELISA, and B cell subpopulations were analyzed by flow cytometry. Based on the results obtained, the formula ([B-naïve%]\[B-memory%]) * ([B-CD38%] + [B-CD5%]) / [anti-MCV] was described. The increase in the calculated index by more than 5 units with a sensitivity of 80.00% and a specificity of 93.10% (AUC = 0.926) suggest the presence of the autoimmune component, which is more typical for sarcoidosis, rather than tuberculosis patients and may serve as a diagnostic criterion.


Assuntos
Anticorpos Antiproteína Citrulinada/imunologia , Autoimunidade/imunologia , Linfócitos B/imunologia , Inflamação/imunologia , Sarcoidose Pulmonar/imunologia , Tuberculose Pulmonar/imunologia , Vimentina/imunologia , Estudos de Casos e Controles , Citrulinação , Ensaio de Imunoadsorção Enzimática , Feminino , Citometria de Fluxo , Humanos , Memória Imunológica , Imunofenotipagem , Masculino , Estudos Prospectivos
5.
Sci Rep ; 10(1): 1059, 2020 01 23.
Artigo em Inglês | MEDLINE | ID: mdl-31974463

RESUMO

Sarcoidosis is a systemic granulomatous disease that develops due to the Th1, Th17 and Treg lymphocytes disturbance. There is an assumption, that B cells and follicular T-helper (Tfh) cells may play an important role in this disorder, as well as in several other autoimmune diseases. The aim of this study was to determine CD19+ B cells subset distribution in the peripheral blood and to define disturbance in the circulating Tfh cells subsets in patients with sarcoidosis. The prospective comparative study was performed in 2016-2018, where peripheral blood B cell subsets and circulating Tfh cell subsets were analyzed in 37 patients with primarily diagnosed sarcoidosis and 35 healthy donors using multicolor flow cytometry. In the results of our study we found the altered distribution of peripheral B cell subsets with a predominance of "naïve" (IgD + CD27-) and activated B cell (Bm2 and Bm2') subsets and a decreased frequency of memory cell (IgD+ CD27+ and IgD- CD27+) in peripheral blood of sarcoidosis patients was demonstrated. Moreover, we found that in sarcoidosis patients there are increased levels of B cell subsets, which were previously shown to display regulatory capacities (CD24+++ CD38+++ and CD5 + CD27-). Next, a significantly higher proportion of CXCR5-expressing CD45RA - CCR7+ Th cells in patients with sarcoidosis in comparison to the healthy controls was revealed, that represents the expansion of this memory Th cell subset in the disease. This is the first study to demonstrate the association between the development of sarcoidosis and imbalance of circulating Tfh cells, especially CCR4- and CXCR3-expressing Tfh subsets. Finally, based on our data we can assume that B cells and Tfh2- and Tfh17-like cells - most effective cell type in supporting B-cell activity, particularly in antibody production - may be involved in the occurrence and development of sarcoidosis and in several other autoimmune conditions. Therefore, we can consider these results as a new evidence of the autoimmune mechanisms in the sarcoidosis development.


Assuntos
Subpopulações de Linfócitos B/citologia , Sarcoidose Pulmonar/sangue , Linfócitos T Auxiliares-Indutores/citologia , Adulto , Subpopulações de Linfócitos B/imunologia , Feminino , Citometria de Fluxo , Humanos , Contagem de Linfócitos , Masculino , Estudos Prospectivos , Sarcoidose Pulmonar/diagnóstico , Sarcoidose Pulmonar/imunologia , Linfócitos T Auxiliares-Indutores/imunologia
6.
Immunol Res ; 66(6): 737-743, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30552618

RESUMO

Clinical and radiological features of tuberculosis and sarcoidosis are quite overlapping, and therefore, a diagnostic dilemma often persists. There are no commonly accepted criteria for the diagnosis of sarcoidosis due to the lack of data on the etiology of the disease. The exclusion of tuberculosis in every patient with suspected sarcoidosis is a mandatory stage of diagnosis, especially in countries with a high burden of tuberculosis. A prospective study was conducted with two groups of patients: group I (n = 50)-patients with pulmonary sarcoidosis established according to standard criteria; group II (n = 28)-patients with pulmonary tuberculosis with bacterial excretion. The control group (n = 24) was presented by healthy subjects. The examination complex included x-ray, bacteriological, immunological (Mantoux test with 2 TE, TB.SPOT test), and histological methods. All patients and healthy subjects were assessed for immune complexes with the use of the dynamic light scattering (DLS) method and adding of "healthy lung tissue extract" antigens and specific tuberculosis antigens ESAT-6 and SFP-10 in vitro. Significant differences were found in determining specific immune complexes in patients with pulmonary sarcoidosis and pulmonary tuberculosis. Registration of specific immune complex formation with "healthy lung tissue extract" in 100% cases may indicate the autoimmune nature of sarcoidosis. The absence of the immune complex formation in response to ESAT-6/SFP-10 antigens can be used for the differential diagnosis of two diseases. The diagnostic significance of the DLS method was 100% for sarcoidosis and 92.2% for tuberculosis. The data obtained in the study allows not only understanding the etiology of sarcoidosis, but also obtaining new criteria for the differential diagnosis of tuberculosis and pulmonary sarcoidosis.


Assuntos
Complexo Antígeno-Anticorpo/imunologia , Sarcoidose Pulmonar/diagnóstico , Sarcoidose Pulmonar/imunologia , Tuberculose Pulmonar/diagnóstico , Tuberculose Pulmonar/imunologia , Diagnóstico Diferencial , Humanos , Testes Imunológicos/métodos , Pulmão/imunologia , Estudos Prospectivos
7.
Ter Arkh ; 88(3): 111-115, 2016.
Artigo em Russo | MEDLINE | ID: mdl-27195324

RESUMO

The paper sets forth the stages of design and introduction of the new Russian tuberculosis (TB) drug perchlozon registered in the Russian Federation in 2012. Based on the results of Phases I-III clinical trials, the authors evaluate the efficacy and safety of the agent and consider the adverse effects of its treatment for respiratory TB. The use of perchlozon as a component of combination therapy versus standard chemotherapy regimens significantly reduces abacillation time in pulmonary TB caused by its drug-resistant pathogen. In terms of the higher prevalence of TB induced by its pathogen resistant to many drugs (with multiple and broad-spectrum drug resistance), perchlozon is an essential drug that has antituberculous activity mainly against multidrug-resistant Mycobacterium tuberculosis strains and gives patients with the severest and epidemiologically poor form of TB the chance to recover.


Assuntos
Antituberculosos/farmacologia , Ensaios Clínicos como Assunto , Descoberta de Drogas , Avaliação de Medicamentos , Resistência Microbiana a Medicamentos , Tuberculose Pulmonar/tratamento farmacológico , Antituberculosos/efeitos adversos , Humanos
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