Multi-Input CNN-LSTM deep learning model for fear level classification based on EEG and peripheral physiological signals.

Objective and accurate classification of fear levels is a socially important task that contributes to developing treatments for Anxiety Disorder, Obsessive-compulsive Disorder, Post-Traumatic Stress Disorder (PTSD), and Phobia. This study examines a deep learning model to automatically estimate human fear levels with high accuracy using multichannel EEG signals and multimodal peripheral physiological signals in the DEAP dataset. The Multi-Input CNN-LSTM classification model combining Convolutional Neural Network (CNN) and Long Sort-Term Memory (LSTM) estimated four fear levels with an accuracy of 98.79% and an F1 score of 99.01% in a 10-fold cross-validation. This study contributes to the following; (1) to present the possibility of recognizing fear emotion with high accuracy using a deep learning model from physiological signals without arbitrary feature extraction or feature selection, (2) to investigate effective deep learning model structures for high-accuracy fear recognition and to propose Multi-Input CNN-LSTM, and (3) to examine the model's tolerance to individual differences in physiological signals and the possibility of improving accuracy through additional learning.

Identifying Core Regions for Path Integration on Medial Entorhinal Cortex of Hippocampal Formation.

Path integration is one of the functions that support the self-localization ability of animals. Path integration outputs position information after an animal's movement when initial-position and movement information is input. The core region responsible for this function has been identified as the medial entorhinal cortex (MEC), which is part of the hippocampal formation that constitutes the limbic system. However, a more specific core region has not yet been identified. This research aims to clarify the detailed structure at the cell-firing level in the core region responsible for path integration from fragmentarily accumulated experimental and theoretical findings by reviewing 77 papers. This research draws a novel diagram that describes the MEC, the hippocampus, and their surrounding regions by focusing on the MEC's input/output (I/O) information. The diagram was created by summarizing the results of exhaustively scrutinizing the papers that are relative to the I/O relationship, the connection relationship, and cell position and firing pattern. From additional investigations, we show function information related to path integration, such as I/O information and the relationship between multiple functions. Furthermore, we constructed an algorithmic hypothesis on I/O information and path-integration calculation method from the diagram and the information of functions related to path integration. The algorithmic hypothesis is composed of regions related to path integration, the I/O relations between them, the calculation performed there, and the information representations (cell-firing pattern) in them. Results of examining the hypothesis confirmed that the core region responsible for path integration was either stellate cells in layer II or pyramidal cells in layer III of the MEC.