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1.
Pediatr Emerg Care ; 37(9): e528-e533, 2021 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-32118836

RESUMO

OBJECTIVES: Metoclopramide is a commonly used medication in pediatric practice, and dystonia is a common adverse effect of it. The present study aims to evaluate the clinical characteristics of metoclopramide-induced acute dystonic reactions (MIADRs) in pediatric patients admitted to the pediatric emergency unit. METHODS: Twenty-eight patients were admitted with MIADRs between June 2004 and April 2016; they were enrolled into the study retrospectively. RESULTS: The study group was composed of 13 females and 15 males with the mean ± SD age of the females higher than that of the males, 12.3 ± 4.5 and 7.8 ± 4.3 years, respectively. Only 9 (32.1%) of the patients were diagnosed as MIADRs at the time of admission. Seventeen patients (60.7%) received over the recommended daily dose of metoclopramide. Dystonia was focal in most of the patients, with the most affected parts consisting of the neck, eyes, and orolingual regions. In 9 of the patients, the dystonia was episodic in nature. Pharmacological treatment was used for 18 patients. No patients died, and none suffered long-term injury related to MIADRs. CONCLUSIONS: Metoclopramide administration may be associated with the occurrence of acute dystonic reaction. Metoclopramide-induced acute dystonic reactions may be misdiagnosed, so detailed medical history gathering and a high index of suspicion are warranted. Our data suggest that MIADRs may be dose related and that there may be age- and sex-related differences in the epidemiology of MIADRs.


Assuntos
Distonia , Distúrbios Distônicos , Adolescente , Criança , Distonia/induzido quimicamente , Distonia/diagnóstico , Serviço Hospitalar de Emergência , Feminino , Humanos , Masculino , Metoclopramida/efeitos adversos , Estudos Retrospectivos
2.
Childs Nerv Syst ; 32(12): 2395-2401, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27514779

RESUMO

BACKGROUND: Perinatal arterial ischemic stroke (PAIS) is an important cause of pediatric morbidity and mortality. The etiology of PAIS remains unknown. Several maternal-neonatal disorders, and especially prothrombotic risk factors, have been reported in infants with perinatal stroke (PS). Rotation thromboelastometry (ROTEM) can analyze the coagulation system, from the beginning of coagulation, through clot formation, and ending with fibrinolysis. The aim of this study was to evaluate the hypercoagulability state in PAIS patients using ROTEM. METHODS: Patients were obtained by evaluating hospital files retrospectively. Twenty patients with PAIS and 19 healthy controls were included in the study. Prothrombotic risk factors and standard coagulation parameters were collected for all patients. Thromboelastometry (TEM) analysis was performed with the ROTEM® Coagulation Analyzer model Gamma 2500 (Tem International, Munich, Germany). Patients were separated into two groups; Group 1 included PAIS patients with prothrombotic risk factors and Group 2 included patients with no prothrombotic risk factors. RESULTS: Group 1 includes six patients and Group 2 includes fourteen. Maternal risk factors were reported in 55 % and prothrombotic risk factors were detected in 30 % of the patients. ROTEM analyses were done mean age of 11.2 ± 9.4 months. ROTEM analysis showed that maximum clot firmness (MCF) value on both groups was significantly higher than in the control group, which is consistent with a hypercoagulable state. There was no statistical difference between the MCF values of Group 1 and Group 2. No significant correlations were found between the ROTEM parameters and the hematological parameters. CONCLUSION: The etiology of PAIS is still unclear. Prothrombotic risk factors may be an important etiology for PAIS. However, standard hematological tests for evaluating prothrombotic risk factors are limited. In our study, ROTEM analyses showed higher maximum clot firmness in PAIS patients compared to controls. ROTEM analyses may suggest a hypercoagulable state due to abnormal fibrinolysis in PAIS patients. Normative data and further research is needed to validate our findings.


Assuntos
Acidente Vascular Cerebral/diagnóstico , Acidente Vascular Cerebral/etiologia , Tromboelastografia/métodos , Trombofilia/diagnóstico , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Estudos Retrospectivos , Trombofilia/complicações
3.
Pediatr Int ; 56(2): 264-6, 2014 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-24730629

RESUMO

Neurological symptoms such as ptosis may develop due to either chemotherapeutic agents or involvement of the central nervous system (CNS) during hematologic malignancy. It is difficult to make this distinction according to clinical symptoms and magnetic resonance imaging findings. If the neurologic symptoms are increased, it is a warning of CNS involvement. Herein are described the clinical and neuroimaging features of three patients with hematologic malignancy who presented with ptosis.


Assuntos
Antineoplásicos/efeitos adversos , Blefaroptose/induzido quimicamente , Neoplasias Hematológicas/tratamento farmacológico , Adolescente , Pré-Escolar , Feminino , Humanos , Lactente , Masculino
4.
Brain Dev ; 36(2): 167-70, 2014 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-23518044

RESUMO

We report a 2-year-old boy with herpes simplex virus type 1 encephalitis (HSE) and opercular syndrome who presented with clinical relapse characterized by chorea-like involuntary movements that suggest akathisia. The patient initially presented with multiple focal seizures that cause epilepsia partialis continua, polymerase chain reaction (PCR) for herpes simplex virus type 1 was positive. He developed hypersalivation, speech and swallowing difficulties within 30days. Based on these findings the patient was diagnosed as having opercular syndrome due to HSE. He developed akathisia on 44th day of admission as a relapse and he was successfully treated with propranolol. Opercular syndrome might be seen HSE in children and it may cause neurological suquela. Akathisia might be seen after encephalitic process as a symptom of relapse, however diagnosis of akathisia is difficult in young children. It should be noted that because propranolol effective for these involuntary movements. It can be add additional choice of treatment in these patients.


Assuntos
Antivirais/uso terapêutico , Encefalite por Herpes Simples/tratamento farmacológico , Epilepsia do Lobo Frontal/tratamento farmacológico , Propranolol/uso terapêutico , Agitação Psicomotora/tratamento farmacológico , Pré-Escolar , Encefalite por Herpes Simples/complicações , Encefalite por Herpes Simples/diagnóstico , Epilepsia do Lobo Frontal/complicações , Epilepsia do Lobo Frontal/diagnóstico , Humanos , Masculino , Agitação Psicomotora/diagnóstico , Agitação Psicomotora/etiologia , Prevenção Secundária , Resultado do Tratamento
5.
Iran J Pediatr ; 24(5): 647-51, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-25793076

RESUMO

BACKGROUND: Extrapulmonary complications of Mycoplasma pneumoniae (M. pneumoniae) infection include encephalitis, optic neuritis, acute psychosis, stroke, cranial nerve palsies, aseptic meningitis and also it may be implicated in immune mediated neurological diseases such as acute demyelinating encephalomyelitis, Guillain-Barre syndrome and transverse myelitis. CASE PRESENTATION: We present five cases with acute neurological diseases after M. pneumoniae infection. The clinical presentations were characterized by encephalitis in 2 patients, Gullain-Barre syndrome in 2 patients, transverse myelitis in 1 patient. M. pneumoniae infection was detected in serum by serological method. Only two patients had respiratory symptoms preceding M. pneumoniae infection. Brain MRI revealed hyperintensities on corpus striatum and mesencephalon in one patient with encephalitis, the other had front parietal coalescent periventricular white matter lesions on T2 images. The patient with transverse myelitis had cervical, dorsal and lumbar scattered hyperintense lesions on T2 images. Two patients were treated with high dose steroid, the other two patients received treatment with intravenous immune globuline. CONCLUSION: M. pneumoniae may reveal different neurologic complications with different radiologic findings.

6.
Iran J Pediatr ; 24(3): 300-6, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25562024

RESUMO

OBJECTIVE: Sydenham's chorea (SC) is thought to be an autoimmune disorder. MRI is generally used to exclude other causes of chorea. There are no typically defined MRI features of SC. In this study we aimed to determine clinical and neuroimaging findings of SC. METHODS: In this study 17 patients with acute SC were retrospectively evaluated. Sydenham's chorea was diagnosed according to the 1992 revision of the Jones criteria. The other causes of chorea were excluded. Cranial MRI was performed in all patients during the acute phase of SC. Walking, speech and swallowing disorders, muscle weakness, behavioral disorders, treatment, symptom recovery time and recurrence were evaluated. Findings : The patients' mean age was 11.2 years. Behavioral changes, muscle weakness and dysphagia occurred in 70%, 64% and 23% of the patients, respectively. Nonspecific signal hyperintensities were observed in the white matter, brain stem and caudate nucleus in 47% of patients. Two patients who had chorea paralytica were treated successfully with a high dose of intravenous methylprednisolone. CONCLUSION: Nonspecific hyperintense white matter abnormalities may be due to the inflammatory process associated with a longer duration of clinical signs. To explain the MRI findings and the pathogenesis of SC, comprehensive studies are needed.

8.
Pediatr Int ; 55(3): 328-31, 2013 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-23782365

RESUMO

BACKGROUND: Breath holding spells (BHS) are known as paroxysmal non-epileptic disorder. There are two subtypes of BHS: cyanotic and the pallid. BHS have been reported to occur in 0.1-4.6% of children in Western countries. Although it is easy to diagnose in its typical form, the data on prevalence of BHS are insufficient in developing countries. METHODS: This study was performed in Turkey's Eskisehir province. A total of 1000 randomly selected 0-6-year-old children were invited to family health centers. A specific questionnaire was given to parents. Children who had a history BHS were referred to the hospital to for investigation of medical history and neurological examinations. RESULTS: A total of 933 children participated and were included in analysis. Thirty-four children (3.6%) had had BHS. Children's birthweight, parent consanguinity and mothers' education status significantly affected the frequency of BHS. Increase in birth sequence decreases the risk of BHS 0.65-fold. Fathers' education status also affected the prevalence of BHS, with the risk of BHS being 0.39-fold less if the father had completed high school or some higher education. And, as the age of the fathers increased, the risk that their children would have BHS was 1.14-fold higher. CONCLUSIONS: Although the calculated prevalence rate was compatible with previous studies, positive family history for BHS, birth sequence, parents' education status and fathers' age were identified as risk factors associated with BHS.


Assuntos
Suspensão da Respiração , Países em Desenvolvimento , Ordem de Nascimento , Suspensão da Respiração/genética , Criança , Pré-Escolar , Consanguinidade , Estudos Transversais , Diagnóstico Diferencial , Escolaridade , Feminino , Inquéritos Epidemiológicos , Humanos , Lactente , Masculino , Idade Paterna , Fatores de Risco , Inquéritos e Questionários , Turquia
9.
Pediatr Neurol ; 48(5): 415-7, 2013 May.
Artigo em Inglês | MEDLINE | ID: mdl-23583064

RESUMO

Palatal tremor is a rare movement disorder characterized by rhythmic movement of the soft palate. There are two subtypes: essential and symptomatic palatal tremor. Essential palatal tremor is characterized by tinnitus and an absence of other neurological deficits. Different treatment options have been used to treat palatal tremor, with varying success rates. Here we describe a patient with essential palatal tremor and who was treated with botulinum toxin injections.


Assuntos
Antidiscinéticos/uso terapêutico , Toxinas Botulínicas/uso terapêutico , Tremor Essencial/tratamento farmacológico , Tremor Essencial/fisiopatologia , Músculos Palatinos/fisiopatologia , Palato Mole/fisiopatologia , Anticonvulsivantes/uso terapêutico , Criança , Eletromiografia , Humanos , Masculino , Exame Neurológico , Zumbido/etiologia
10.
BMJ Case Rep ; 20132013 Feb 14.
Artigo em Inglês | MEDLINE | ID: mdl-23417386

RESUMO

Spinal tumours are observed in about 40% of neurofibromatosis type 1 (NF1) patients and occur within two subgroups: (1) NF1 patients carrying classical diagnostic criteria and only one or few spinal tumours and (2) patients with few NF1 stigmata but multiple bilateral spinal tumours, an entity called spinal neurofibromatosis. We report a young patient whose classical NF1 stigmata and numerous spinal neurofibromas matched both groups. He carried a single base deletion, c.389delA in exon 4a, which creates a premature termination at codon 164. This case illustrates the possibility of variant phenotypes and a novel NF1 mutation associated with spinal neurofibromatosis.


Assuntos
Genes da Neurofibromatose 1 , Mutação , Neurofibromatose 1/genética , Neoplasias da Medula Espinal/genética , Adolescente , Vértebras Cervicais , Diagnóstico Diferencial , Humanos , Imageamento por Ressonância Magnética , Masculino , Neurofibromatose 1/diagnóstico , Linhagem , Neoplasias da Medula Espinal/diagnóstico
11.
BMJ Case Rep ; 20132013 Jan 23.
Artigo em Inglês | MEDLINE | ID: mdl-23345532

RESUMO

Marcus Gunn jaw winking synkinesis (MGJWS) is caused by congenital miswiring of a branch of the fifth cranial nerve into the branch of the third cranial nerve supplying the levator muscle. It has been observed in 2-13% of patients with congenital ptosis. Although bilateral cases were reported, most were unilateral and occurred more frequently on the left side than the right. We report two cases of children who presented with ptosis and were diagnosed with MGJWS.


Assuntos
Blefaroptose/diagnóstico , Blefaroptose/fisiopatologia , Cardiopatias Congênitas/diagnóstico , Cardiopatias Congênitas/fisiopatologia , Anormalidades Maxilomandibulares/diagnóstico , Anormalidades Maxilomandibulares/fisiopatologia , Doenças do Sistema Nervoso/diagnóstico , Doenças do Sistema Nervoso/fisiopatologia , Blefaroptose/congênito , Criança , Diagnóstico Diferencial , Pálpebras/fisiopatologia , Feminino , Humanos , Lactente , Doenças do Sistema Nervoso/congênito , Músculos Oculomotores/inervação , Nervo Oculomotor/anormalidades , Reflexo Anormal , Nervo Trigêmeo/anormalidades
12.
BMJ Case Rep ; 20132013 Jan 09.
Artigo em Inglês | MEDLINE | ID: mdl-23307455

RESUMO

Encephalitis is an uncommon neurological complication of Ebstein-Barr virus (EBV) infection and usually presents with confusion, decreased level of consciousness, fever, epileptic seizure, emotional instability and chorea. We present a patient with EBV encephalitis, characterised by nominal dysphasia, euphoria and personality changes.


Assuntos
Anomia/etiologia , Anticorpos Antivirais/análise , Encefalite Viral/complicações , Infecções por Vírus Epstein-Barr/complicações , Euforia , Herpesvirus Humano 4/imunologia , Adolescente , Anomia/diagnóstico , Diagnóstico Diferencial , Encefalite Viral/virologia , Infecções por Vírus Epstein-Barr/virologia , Feminino , Humanos , Imageamento por Ressonância Magnética
13.
Childs Nerv Syst ; 28(12): 2181-3, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-22965773

RESUMO

PURPOSE: Neurofibromatosis-Noonan syndrome is a rare autosomal dominant disorder which combines neurofibromatosis type 1 (NF1) features with Noonan syndrome. NF1 gene mutations are reported in the majority of these patients. METHOD: Sequence analysis of the established genes for Noonan syndrome revealed no mutation; a heterozygous NF1 point mutation c.7549C>T in exon 51, creating a premature stop codon (p.R2517X), had been demonstrated. RESULT: Neurofibromatosis-Noonan syndrome recently has been considered a subtype of NF1 and caused by different NF1 mutations. CONCLUSION: We report the case of a 14-year-old boy with neurofibromatosis type 1 with Noonan-like features, who complained of headache with triventricular hydrocephaly and a heterozygous NF1 point mutation c.7549C>T in exon 51.


Assuntos
Códon sem Sentido/genética , Genes da Neurofibromatose 1/fisiologia , Neurofibromatose 1/genética , Síndrome de Noonan/genética , Adolescente , Osso e Ossos/diagnóstico por imagem , Códon/genética , Códon sem Sentido/fisiologia , Éxons/genética , Cabeça/anatomia & histologia , Cefaleia/etiologia , Humanos , Hidrocefalia/patologia , Masculino , Náusea/etiologia , Neurofibromatose 1/diagnóstico por imagem , Síndrome de Noonan/diagnóstico por imagem , Mutação Puntual/genética , Mutação Puntual/fisiologia , Reação em Cadeia da Polimerase , Radiografia , Vômito/etiologia
15.
Neuropediatrics ; 43(3): 149-51, 2012 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-22473286

RESUMO

Subacute sclerosing panencephalitis (SSPE) is a progressive neurodegenerative disorder. Ocular involvement in SSPE has been well known and might be seen in 42 to 50% of the patients. Visual findings are generally seen at stage III with neurological abnormalities. Ophthalmologic involvement might be preceding typical SSPE symptoms.


Assuntos
Coriorretinite/diagnóstico , Panencefalite Esclerosante Subaguda/diagnóstico , Adolescente , Humanos , Masculino
16.
Brain Dev ; 34(10): 824-8, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-22445289

RESUMO

Nonconvulsive status epilepticus (NCSE) is a specific form of status epilepticus and is defined as epileptic activity on an EEG without seizures and as an alteration in mental status lasting more than 30 min. NCSE may be caused by drugs, cerebrovascular events, metabolic disorders or toxins. Herein, we present four cases of patients with drug-induced NCSE who were chronically ill due to renal failure or childhood leukemia. NCSE should be suspected in patients with an altered mental status without clinical seizures who are being treated with multiple drugs.


Assuntos
Síndromes Neurotóxicas/tratamento farmacológico , Estado Epiléptico/induzido quimicamente , Estado Epiléptico/tratamento farmacológico , Adolescente , Criança , Pré-Escolar , Doença Crônica , Eletroencefalografia , Feminino , Humanos , Leucemia Mieloide Aguda/tratamento farmacológico , Masculino , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico , Insuficiência Renal/tratamento farmacológico , Estado Epiléptico/diagnóstico , Resultado do Tratamento
18.
Eur J Pediatr ; 170(7): 873-7, 2011 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-21140275

RESUMO

Recent reports have demonstrated elevated serum homocysteine (Hcy) levels in children receiving valproic acid (VPA) therapy. Elevated Hcy levels might play a potential role in the resistance to antiepileptic drugs, and might lead to an increased risk for a vascular disease. It has been reported that elevated total homocysteine (tHcy) levels are associated with elevated asymmetric dimethylarginine (ADMA) levels, which are factors that may be better indicators of endothelial dysfunction compared to serum homocysteine levels, because they are less sensitive to changes, such as fasting status, physical activity, and other factors. In this study, we aim to evaluate serum ADMA, Hcy, lipid, folate, and vitamin B12 levels in epileptic children, receiving VPA monotherapy. Forty-four epileptic children, receiving VPA monotherapy for at least 6 months and 28 healthy children aged between 4 and 16 years, were recruited. Serum lipids, lipoproteins, folate, vitamin B12, Hcy, and ADMA levels were analyzed in both study groups. Serum Hcy, ADMA, and vitamin B12 levels were higher in patients than in controls (p < 0.001 for tHcy and ADMA levels; p < 0.05 for vitamin B12 levels); however, serum lipid, lipoprotein, and folate levels were similar. According to the duration of epilepsy, serum tHcy, ADMA, and triglyceride (TG) levels were higher in patients with epilepsy for ≥ 2 years than in patients with epilepsy for < 2 years (p < 0.001 for serum ADMA levels, p < 0.01 for tHcy levels, and p < 0.05 for serum TG levels). Similarly, with respect to the duration of VPA therapy, serum tHcy, ADMA, and TG levels were higher in patients who had received VPA therapy for more than 2 years (p < 0.001 for serum ADMA levels, p < 0.05 for serum tHcy levels, p < 0.01 for TG levels). Serum ADMA levels were significantly higher in patients receiving VPA at the dose of 25-30 mg/kg/day than in those receiving 20 mg/kg/day (p < 0.01). In conclusion, our study found increased serum ADMA levels and increased tHcy levels in epileptic children receiving VPA monotherapy. Increased serum ADMA levels were demonstrated in epileptic children who have had a seizure history greater than 2 years, and have used VPA therapy for more than 2 years, and have received higher doses of VPA. Routine monitoring of serum ADMA and tHcy levels might have beneficial effects for patients receiving long-term VPA therapy, especially in children who have other potential risk factors for vascular diseases. Further studies are needed to investigate serum ADMA and Hcy levels, and the presence of vascular disease, as well as the potential interactions between serum ADMA levels and seizure control.


Assuntos
Anticonvulsivantes/uso terapêutico , Arginina/análogos & derivados , Epilepsia/tratamento farmacológico , Homocisteína/sangue , Lipídeos/sangue , Ácido Valproico/uso terapêutico , Complexo Vitamínico B/sangue , Adolescente , Anticonvulsivantes/farmacologia , Arginina/sangue , Biomarcadores/sangue , Estudos de Casos e Controles , Criança , Pré-Escolar , Colesterol/sangue , Estudos Transversais , Esquema de Medicação , Epilepsia/sangue , Feminino , Ácido Fólico/sangue , Humanos , Masculino , Triglicerídeos/sangue , Ácido Valproico/farmacologia , Vitamina B 12/sangue
19.
Pediatr Neurol ; 43(1): 76-8, 2010 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-20682211

RESUMO

The association of septo-optic dysplasia and cortical dysplasia is described as septo-optic dysplasia-plus. Reports on patients with septo-optic dysplasia-plus have been rare. We describe a 4-year-old girl with septo-optic dysplasia-plus syndrome, characterized by septo-optic dysplasia with schizencephaly, pachygyria, and diabetes insipidus.


Assuntos
Diabetes Insípido/patologia , Lisencefalia/patologia , Malformações do Desenvolvimento Cortical/patologia , Displasia Septo-Óptica/patologia , Pré-Escolar , Feminino , Humanos , Imageamento por Ressonância Magnética , Síndrome
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