RESUMO
OBJECTIVE: To study the effects of Rhizoma Coptidis extracts and Rhizoma Coptidis and Cortex Cinnamomi extracts on the distribution of terberine in rats' tissues. METHODS: The rats were intragastrically given the two different extracts. HPLC was used to determine the concentration of berberine in rats' tissues and the sample was extracted by liquid-liquid extraction method. RESULTS: At the same time, with the same gavage of the three extracts, the trend of the berberine in rats was: the concentration of Rhizoma Coptidis and Cortex Cinnamomi extracts > the concentration of Rhizoma Coptidis extracts. CONCLUSION: Berberine can be detected in intestinal, stomach, colon, pancreatic, heart, kidney, liver, spleen, lung, testicular, uterus, especially the gastrointestinal system with higher concentration, so berberine has a wide range of distribution in vivo.
