Rhizobium inoculation enhances copper tolerance by affecting copper uptake and regulating the ascorbate-glutathione cycle and phytochelatin biosynthesis-related gene expression in Medicago sativa seedlings.

Despite numerous reports that legume-rhizobium symbiosis alleviates Cu stress in plants, the possible roles of legume-rhizobium symbiosis and the regulatory mechanisms in counteracting Cu toxicity remain unclear. Here, Sinorhizobium meliloti CCNWSX0020 was used for analyzing the effects of rhizobium inoculation on plant growth in Medicago sativa seedlings under Cu stress. Our results showed that rhizobium inoculation alleviated Cu-induced growth inhibition, and increased nitrogen concentration in M. sativa seedlings. Moreover, the total amount of Cu uptake in inoculated plants was significantly increased compared with non-inoculated plants, and the increase in the roots was much higher than that in the shoots, thus decreasing the transfer coefficient and promoting Cu phytostabilization. Cu stress induced lipid peroxidation and reactive oxygen species production, but rhizobium inoculation reduced these components' accumulation through altering antioxidant enzyme activities and regulating ascorbate-glutathione cycles. Furthermore, legume-rhizobium symbiosis regulated the gene expression involved in antioxidant responses, phytochelatin (PC) biosynthesis, and metallothionein biosynthesis in M. sativa seedlings under Cu stress. Our results demonstrate that rhizobium inoculation enhanced Cu tolerance by affecting Cu uptake, regulating antioxidant enzyme activities and the ascorbate-glutathione cycle, and influencing PC biosynthesis-related gene expression in M. sativa. The results provide an efficient strategy for phytoremediation of Cu-contaminated soils.

Interaction between family history and waist circumference on incidence of hypertension / 西安交通大学学报(医学版)

Objective To analyze the interaction between family history and waist circumference on incidence of hypertension .Methods We conducted a cross-sectional survey of rural residents in Hanzhong .Questionnaires about hypertension were collected and physical examination was conducted .A total of 3030 rural residents' data were collected . Logistic regression model was used to analyze the influences of family history and waist circumference on hypertension . Additive model and multiplicative model were used to analyze the interaction between family history and waist circumference on hypertension .Results For hypertension , Logistic regression analysis showed that family history (OR :2 .225 ,95% CI:1 .843-2 .687) and abdominal obesity (OR :1 .976 ,95%CI :1 .649-2 .368) were positively associated after adjustment for age ,sex ,salt intake ,smoking ,and alcohol drinking .Family history and waist circumference had no interaction on incidence of hypertension on a multiplicative scale but an interaction on an additive scale .The relative excess risk due to interaction (RERI) was 1 .848 (95% CI :0 .693-3 .002) ,the attributable proportion due to interaction (AP) was 0 .404 (95% CI :0 .227 -0 .582) and the synergy index (S) was 2 .073 (95% CI :1 .340 -3 .206 ) .Conclusion Family history and abdominal obesity are risk factors for hypertension . The incidence of hypertension of people with both family history and abdominal obesity is obviously higher than the sum of the two risk factors separately .Therefore ,to prevent hypertension it is more important for people to control their weight when they have a positive family history .

Effects of intensive medication nursing during oral medication of hypertensive / 中国生化药物杂志

Objective To discuss the effect of intensive medication nursing on drug compliance and blood pressure control of patients during oral medication treatment of hypertension. Methods 76 patients with primary hypertension were randomly divided into the intervention group (strengthen medication 38 cases) and the conventional group (routine nursing group, 38 cases) in the Hangzhou Geriatric hospital from March 2016 to April 2017. SBP and DBP were measured before and after treatment in two groups. Results The drug compliance of the patients in the intervention group was significantly higher than that in the conventional group (P<0.05). There was no significant difference in SBP and DBP between of two groups before intervention. After intervention treatment, the levels of SBP and DBP in the intervention group were lower than those in the conventional group (P<0.05). Conclusion Intensive medication nursing of hypertension during oral medication could significantly improve the drug compliance of patients and improve the effects of blood pressure control in patients.

Effects of intensive medication nursing during oral medication of hypertensive / 中国生化药物杂志

Objective To discuss the effect of intensive medication nursing on drug compliance and blood pressure control of patients during oral medication treatment of hypertension. Methods 76 patients with primary hypertension were randomly divided into the intervention group (strengthen medication 38 cases) and the conventional group (routine nursing group, 38 cases) in the Hangzhou Geriatric hospital from March 2016 to April 2017. SBP and DBP were measured before and after treatment in two groups. Results The drug compliance of the patients in the intervention group was significantly higher than that in the conventional group (P<0.05). There was no significant difference in SBP and DBP between of two groups before intervention. After intervention treatment, the levels of SBP and DBP in the intervention group were lower than those in the conventional group (P<0.05). Conclusion Intensive medication nursing of hypertension during oral medication could significantly improve the drug compliance of patients and improve the effects of blood pressure control in patients.