1.
Comp Biochem Physiol C Comp Pharmacol Toxicol
; 101(3): 475-9, 1992 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-1354124
RESUMO
1. The activity of the rat liver monooxygenase system after single and combined treatment with Fasciola hepatica and diethylnitrosamine (DENA) has been studied in a 27-week experiment. 2. The changes in lever drug metabolism were due mainly to F. hepatica with DENA having a modulating effect only. 3. The results are discussed with reference to earlier data of ours concerning the effects of stimulation or inhibition of DENA-induced liver carcinogenesis against a background of acute or chronic fascioliasis.