An Improved Approach for Practical Synthesis of 5-Hydroxymethyl-2'-deoxycytidine (5hmdC) Phosphoramidite and Triphosphate.

5-Hydroxymethyl-2'-deoxycytidine (5hmdC) phosphoramidite and triphosphate are important building blocks in 5hmdC-containing DNA synthesis for epigenetic studies. However, efficient and practical methods for the synthesis of these compounds are still limited. The current research provides an intensively improved synthetic method that enables the preparation of commercially available cyanoethyl-protected 5hmdC phosphoramidite with an overall yield of 39% on 5 g scale. On the basis of facile and efficient accesses to cyanoethyl protected-5hmdU and 5hmdC intermediates, two efficient synthetic routes for 5hmdC triphosphate were also developed.

Hf(OTf)4-Catalyzed Three-Component Synthesis of N-Carbamate-Protected ß-Amino Ketones.

Hafnium(IV) triflate (Hf(OTf)4) has been identified as a potent catalyst for the direct three-component synthesis of ß-carbamate ketones. This new method, featuring a low catalyst loading, fast reaction rate, and solvent-free conditions, provided facile access to a diversity of carbamate-protected Mannich bases. A mechanistic investigation indicated that the three-component reaction proceeds via sequential aldol condensation and aza-Michael addition, but not the Mannich-type pathway.

Photo-Switchable Aggregation-Induced Emission of Bisthienylethene-Dipyrimido[2,1-b][1,3]benzothiazole Triad.

A bisthienylethene-dipyrimido[2,1-b][1,3]benzothiazole (BTE-2PBT) triad has been designed and synthesized based on our recent discovery of PBTs as atypical propeller-shaped novel AIEgens. The triad not only maintains the photochromic properties of BTE moiety in solution, film, and solid state but also exhibits remarkable AIE properties. Moreover, the fluorescence of BTE-2PBT PMMA film could be modulated with high contrast by alternate UV and visible light irradiation. Photoerasing, rewriting, and non-destructive readout of fluorescent images on BTE-2PBT PMMA film well demonstrate its potential application as optical memory media.

Access management strategy of large medical equipment based on the government function reform and market development effect / 中国卫生政策研究

Based on the relationship between government and market,this paper analyzed the development process of large medical equipment configuration management strategy,and forecasted the trend of management.It is found that the development process of large equipment management in China can be divided into four stages:sprouting stage,management window period,growth stage,and transition period.The management model of the four stages,respectively,are integrated management,market-oriented management,quantitative control-based comprehensive supervision,and legal supervision.As per the analysis of this work,it was found that the sprouting of the regulation of industry standards,training professionals,management efficiency are low;market-oriented led to rapid growth in the number of equipment,with a low configuration efficiency;growth period of the number of regulatory norms of the market and equipment is reasonable to use;and the legal supervision in transition is taking shape.Currently,the lack of rational allocation of large-scale equipment in the hospitals is the main factor leading to market failure.In the legal framework,the government intervention with configuration permits is the major large-scale equipment configuration management model in the future.

Access management strategy of large medical equipment based on the government function reform and market development effect / 中国卫生政策研究

Based on the relationship between government and market,this paper analyzed the development process of large medical equipment configuration management strategy,and forecasted the trend of management.It is found that the development process of large equipment management in China can be divided into four stages:sprouting stage,management window period,growth stage,and transition period.The management model of the four stages,respectively,are integrated management,market-oriented management,quantitative control-based comprehensive supervision,and legal supervision.As per the analysis of this work,it was found that the sprouting of the regulation of industry standards,training professionals,management efficiency are low;market-oriented led to rapid growth in the number of equipment,with a low configuration efficiency;growth period of the number of regulatory norms of the market and equipment is reasonable to use;and the legal supervision in transition is taking shape.Currently,the lack of rational allocation of large-scale equipment in the hospitals is the main factor leading to market failure.In the legal framework,the government intervention with configuration permits is the major large-scale equipment configuration management model in the future.

[The comparisive study of the clinical effect of rotary self-locking intramedullary nail and intramedullary interlocking nail for the treatment of femur fracture].

OBJECTIVE: To compare the clinical effect of rotary self-locking intramedullary nail (RSIN) and intramedullary interlocking nail (IIN) for the treatment of fresh femoral shaft fracture. METHODS: The radiological records of 60 fresh femoral shaft fractures (41 stable fractures and 19 unstable fractures) were retrospectively analyzed. Among them, 49 were male and 11 were female. The average age was 33.5 years old (range from 12 to 68 years old). All cases were fresh fracture with no important blood vessel or nerve injury, which were taken operation with RSIN on IIN respectively in 2 h-7 d after injury. The patients in IIN group began functional movements at postoperative 4 to 5 days and could bear the weight of 10-15 kg. The patients in RSIN group could began functional exercises after the wound healed and bear partly weight after 6 weeks. Both groups were contrasted on the biomechanics, operation procedure, fracture healing time, functional recovery and operative indication. RESULTS: Both groups were followed-up for average 13 months. IIN group: the average healing time of closed femur fracture was 16 weeks while that of open fracture was 20 weeks. The healing rate was 100% and the malunion rate was 7.9%. The excellent and good rate of functional recovery was 93.3% including excellent in 27 cases, good in 1, fair in 1 and bad in 1. RSIN group: the average healing time of closed femur fracture was 16 weeks while open fracture was 23 weeks. The healing rate was 87% and the malunion rate was 18.2%. The excellent and good rate of functional recovery was 83.3% including excellent in 23 cases, good in 2, fair in 3 and bad in 2. No implant break and nonunion happened. The differences between two groups in healing time, deformity-union rate and the rate of the twice operation were statistically significant. CONCLUSION: IIN provides a reliable and practical alternative method for the treatment of all kinds of femoral shaft fracture and its important complication is fewer than RSIN group. RSIN also has a good curative effect in its own indication.