Effects of abdominal compartment syndrome on circulation and respiratory function in rabbits / 南方医科大学学报

<p><b>OBJECTIVE</b>To establish a rabbit model of abdominal compartment syndrome (ACS) and evaluate the impact of ACS on cardiovascular and respiratory functions and blood electrolyte levels in rabbits.</p><p><b>METHODS</b>Twenty-four New Zealand rabbits were randomly allocated into 4 equal groups, namely the normal control group, ACS(5>\) group [intra-abdominal pressure (IAP)=5 mmHg], ACS(10) group (IAP=10 mmHg) and ACS(20) group (IAP=20 mmHg). ACS model was established by intra- abdominal bleeding (IAB) with intra-abdominal hypertension (IAH). All the data were recorded 1 h after inducing IAH including cardiovascular parameters (LVSP, LVEDP, ∓dp/dt max, SP, DP, HR, CVP), respiratory function (RR, PaO(2), PaCO(2), [HCO(3)(-)]), blood pH, and electrolyte level ([K(+)]).</p><p><b>RESULTS</b>Compared with those in the normal control group, ACS20 group showed significantly decreased LVSP, LVEDP, ∓dp/dt max, SP, DP, HR, RR, PaO(2), [HCO(3)(-)], and blood pH but increased CVP, PaCO(2), and K(+) (P<0.05). In ACS(10) group, all the parameters except for RR and PaO(2) showed similar changes as seen in ACS(20) group (P<0.05) but with lower amplitudes of variations. In ACS(5) group, only LVSP and HR were reduced remarkably (P<0.05) while the other parameters showed no significant variations.</p><p><b>CONCLUSION</b>IAB plus IAH may cause damage to the cardiovascular and respiratory functions and lead to ACS in rabbits.</p>

Prognostic factors in cholangiocarcinoma / 中国普通外科杂志

Objective　To study the prognostic factors in cholangocarcinoma(CC). Methods　Retrospective analysis of the reported clinical data of CC in lectures. Results and Conclusions　The prognosis of CC in lower portion of bile duct(BD) is much better, CC in meddle portion of BD take the second place of prognosis, CC in upper portion of BD has the worst prognosis. If CC with following cases, which would have much better prognosis: higher differentiation without metastasis, diploid, higher PCNA; if CC with negative expression of epithelial membrane antigen or keratine, which would have worse prognosis. The activate of type IV collegen is related linearly to the metastasis capacity of the tumor, and the expression of nm23 of tumor is related to invation, lymphatic metastasis and prognosis of the tumor. Radical resection of the tumor has the best effect, palliative resection take the second place of prognosis, internal or external drainage operation has the worst effect. The effect of local radiotherapy is limited, and chemotherapy showes no effect. Early diagnosis, radical or extending resection and combined therapy can improve the prognosis of CC.