Effect of virtual reality-based exercise and physical exercise on adolescents with overweight and obesity: study protocol for a randomised controlled trial.

INTRODUCTION: Obesity is a complex and multifactorial disease that has affected many adolescents in recent decades. Clinical practice guidelines recommend exercise as the key treatment option for adolescents with overweight and obesity. However, the effects of virtual reality (VR) exercise on the physical and brain health of adolescents with overweight and obese remain unclear. This study aims to evaluate the effects of physical and VR exercises on physical and brain outcomes and explore the differences in benefits between them. Moreover, we will apply a multiomics analysis to investigate the mechanism underlying the effects of physical and VR exercises on adolescents with overweight and obesity. METHODS AND ANALYSIS: This randomised controlled clinical trial will include 220 adolescents with overweight and obesity aged between 11 and 17 years. The participants will be randomised into five groups after screening. Participants in the exercise groups will perform an exercise programme by adding physical or VR table tennis or soccer classes to routine physical education classes in schools three times a week for 8 weeks. Participants in the control group will maintain their usual physical activity. The primary outcome will be the change in body fat mass measured using bioelectrical impedance analysis. The secondary outcomes will include changes in other physical health-related parameters, brain health-related parameters and multiomics variables. ETHICS AND DISSEMINATION: This study was approved by the Ethics Committee of Shanghai Sixth People's Hospital and registered in the Chinese Clinical Trial Registry. Dissemination of the findings will include peer-reviewed publications, conference presentations and media releases. TRIAL REGISTRATION NUMBER: ChiCTR2300068786.

It's time for attentional control: Temporal expectation in the attentional blink.

The attentional blink (AB) reveals a limitation in conscious processing of sequential targets. Although it is widely held that the AB derives from a structural bottleneck of central capacity, how the central processing is constrained is still unclear. As the AB reflects the dilemma of deploying attentional resources in the time dimension, research on temporal allocation provides an important avenue for understanding the mechanism. Here we reviewed studies regarding the role of temporal expectation in modulating the AB performance primarily based on two temporal processing strategies: interval-based and rhythm-based timings. We showed that both temporal expectations can help to organize limited resources among multiple attentional episodes, thereby mitigating the AB effect. As it turns out, scrutinizing on the AB from a temporal perspective is a promising way to comprehend the mechanisms behind the AB and conscious cognition. We also highlighted some unresolved issues and discussed potential directions for future research.

Attentional bias towards appealing and disgusting food cues varies with the menstrual cycle.

Ovarian hormonal changes along the female menstrual cycle are believed to adapt women to the external environment through various adaptive strategies, including modulating appetite and eating behavior. We aimed to compare food-associated behavioral responses between two distinct menstrual phases (late follicular vs. mid-luteal) and investigate the underlying neural mechanism. Attentional bias towards visual food cues was repeatedly measured in 29 healthy young women during these two menstrual phases in a counterbalanced manner. Combining an emotional dot-probe task with frequency-tagged electroencephalography (EEG), we confirmed that the menstrual cycle modulated healthy women's attentional bias towards appealing and disgusting food cues. Women in the mid-luteal phase showed more avoidance of disgusting food cues, as reflected by a significantly longer response time. Steady-state visual evoked potential (SSVEP) results indicated that they exhibited a trend of transiently enhanced attentional bias towards appealing food cues and another trend of speeded attentional withdrawal from disgusting food cues during the mid-luteal phase relative to the late follicular phase, albeit non-significant after correction for multiple testing. Moreover, a significantly larger P3 amplitude was evoked by probes following the presentation of disgusting food cues in the mid-luteal phase than the late follicular phase. These findings indicate divergent attentional deployments on emotional food cues across menstrual phases and suggest the mid-luteal phase as a relatively sensitive stage in the menstrual cycle for women to regulate their appetite and eating behavior.

Immediate Temporal Information Modulates the Target Identification in the Attentional Blink.

It has been shown that learned temporal information can be exploited to help facilitate the target identification in the attentional blink task. Here, we tested whether similar exploitation also worked on short-term temporal information, even when it did not reliably predict the target onset. In two experiments, we randomly manipulated either the interval between targets (T1 and T2; Experiment 1) or the temporal regularity of stimulus presentation (Experiment 2) in each trial. The results revealed evidence of effects of immediate temporal experience mainly on T2 performances but also occasionally on T1 performances. In general, the accuracy of T2 was enhanced when a longer inter-target interval was explicitly processed in the preceding trial (Experiment 1) or the temporal regularity, regardless of being explicitly or implicitly processed, was present in the stimulus stream, especially after T1 (Experiment 2). These results suggest that, under high temporal uncertainty, both interval and rhythmic cues can still be exploited to regulate the allocation of processing resources, thus, modulating the target identification in the attentional blink task, consistent with the view of flexible attentional allocation, and further highlighting the importance of the interplay between temporal processing and attentional control in the conscious visual perception.

Mid-Luteal Olfactory Abilities Reveal Healthy Women's Emotional and Cognitive Functions.

Ovarian hormones modulate women's physical and psychological states periodically. Although the olfactory function is increasingly recognized as a reflection of physical and mental health conditions in the clinic, the role of olfaction in emotional and cognitive functions for healthy individuals has yet to be elucidated, especially when taking the menstrual cycle into account. We carried out a comprehensive investigation to explore whether the menstrual cycle could modulate women's olfactory function and whether healthy women's emotional symptoms and behavioral impulsivity could be characterized by their olfactory abilities at a specific menstrual cycle stage. Twenty-nine healthy young women were evaluated repeatedly using a standard olfactory test battery during the late follicular and mid-luteal phases. Their emotional symptoms and behavioral impulsivity were separately quantified via psychometric scales and a stop-signal task. We observed enhanced olfactory discrimination performance during the mid-luteal phase than the late follicular phase. We also found that women's better olfactory discrimination and worse olfactory threshold in the mid-luteal phase predicted fewer individual emotional symptoms and lower behavioral impulsivity, respectively. These relationships were nonetheless absent in the late follicular phase. Our data extend previous clinical observations of the coexistence of olfactory deficits and neuropsychiatric disorders, providing new insights into the significance of olfaction and ovarian hormones for emotional and cognitive functions.

Nasal airflow engages central olfactory processing and shapes olfactory percepts.

Binding of airborne odour molecules to olfactory receptors at the top of the nasal cavity gives rise to our rich olfactory experience. Whether airflow plays a role in human olfactory perception beyond the transportation of odorants is scantly known. Combining psychophysical measures with strict controls of nasal flow parameters, we demonstrate in four experiments that the perceived intensity of a unilaterally presented odour decreases systematically with the amount of contralateral nasal airflow, in manners that are independent of odour flow rate, nasal pressure, perceived sniff vigour or attentional allocation. Moreover, the effect is due to the sensed rather than the factual amount of nasal flow, as applying a local anaesthetic to the contralateral nostril produces the same effect as physically blocking it. Our findings indicate that nasal flow spontaneously engages central olfactory processing and serves as an integral part of the olfactory percept in humans.

Development of the Chinese Smell Identification Test.

Smell identification ability reflects the functional integrity of the human olfactory system. Its deficit is a prodromal marker for Parkinson's disease and is also implicated in Alzheimer's disease and other neurological and psychiatric disorders. Considering the impact of cultural factors on odor identifiability, we have developed a smell identification test specifically for the Chinese population (CSIT), which includes 40 odor items that are familiar to this population, presented in a multiple-choice format. The CSIT has a test-retest reliability of 0.92 and is validated against the University of Pennsylvania Smell Identification Test (UPSIT) and the Sniffin' Sticks Identification Test 16 (SS-16). In terms of identification accuracy, Chinese participants on average score 15% higher on the CSIT than on the UPSIT or SS-16. The CSIT is also sensitive to age and gender differences in smell identification ability. As such, the CSIT provides an effective tool for the assessment of olfactory function in the Chinese population.

How Does Adult Attachment Affect Human Recognition of Love-related and Sex-related Stimuli: An ERP Study.

In the present study, we investigated the relationship among three emotion-motivation systems (adult attachment, romantic love, and sex). We recorded event-related potentials in 37 healthy volunteers who had experienced romantic love while they viewed SEX, LOVE, FRIEND, SPORT, and NEUTRAL images. We also measured adult attachment styles, level of passionate love and sexual attitudes. As expected, results showed that, firstly, response to love-related image-stimuli and sex-related image-stimuli on the electrophysiological data significantly different on N1, N2, and positive slow wave (PSW) components. Secondly, the different adult attachment styles affected individuals' recognition processing in response to love-related and sex-related images, especially, to sex-related images. Further analysis showed that voltages elicited by fearful attachment style individuals were significantly lower than voltages elicited by secure and dismissing attachment style individuals on sex-related images at frontal sites, on N1 and N2 components. Thirdly, from behavior data, we found that adult attachment styles were not significantly related to any dimension of sexual attitudes but were significantly related to passionate love scale (PLS) total points. Thus, the behavior results were not in line with the electrophysiological results. The present study proved that adult attachment styles might mediate individuals' lust and attraction systems.