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Pulmonary magnetic resonance imaging (MRI) has historically been challenging because of the low proton density of the lungs and respiratory and susceptibility artifacts; however, recent advancements in technology have made it increasingly useful for the diagnosis and monitoring of lung diseases, such as lung cancer and chronic obstructive pulmonary disease. No previous studies have specifically focused on the use of pulmonary MRI in eosinophilic lung disease. This case report presents the first case of Löffler’s syndrome incidentally detected in abdominal MRI. The patient was diagnosed with Löffler’s syndrome based on pulmonary opacities and increased peripheral blood eosinophil counts. Followup computed tomography revealed that pulmonary opacities were resolved. In this case, MRI distinguished between a solid nodule and the surrounding ground-glass opacity.Thus, our report can be considered representative of magnetic resonance (MR) findings for Löffler’s syndrome. Our observations also highlight the importance of increasing radiological familiarity with MR findings in various pulmonary diseases.
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Purpose@#To evaluate the association between magnetic resonance imaging (MRI)-based texture parameters and Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation in patients with non-mucinous rectal cancer. @*Materials and Methods@#Seventy-nine patients who had pathologically confirmed rectal nonmucinous adenocarcinoma with or without KRAS-mutation and had undergone rectal MRI were divided into a training (n = 46) and validation dataset (n = 33). A texture analysis was performed on the axial T2-weighted images. The association was statistically analyzed using the Mann-Whitney U test. To extract an optimal cut-off value for the prediction of KRAS mutation, a receiver operating characteristic curve analysis was performed. The cut-off value was verified using the validation dataset. @*Results@#In the training dataset, skewness in the mutant group (n = 22) was significantly higher than in the wild-type group (n = 24) (0.221 ± 0.283; -0.006 ± 0.178, respectively, p = 0.003). The area under the curve of the skewness was 0.757 (95% confidence interval, 0.606 to 0.872) with a maximum accuracy of 71%, a sensitivity of 64%, and a specificity of 78%. None of the other texture parameters were associated with KRAS mutation (p > 0.05). When a cut-off value of 0.078 was applied to the validation dataset, this had an accuracy of 76%, a sensitivity of 86%, and a specificity of 68%. @*Conclusion@#Skewness was associated with KRAS mutation in patients with non-mucinous rectal cancer.
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Anti-myelin oligodendrocyte glycoprotein (anti-MOG) syndrome is an immunemediated inflammatory condition of the central nervous system, which usually involves spinal cord and optic nerves. Herein, we studied the case of a 57-yearold female patient who presented with acute/subacute symptoms of sphincter dysfunction, paraparesis, and ocular pain. The patient was diagnosed with anti-MOG syndrome with findings resembling snake-eye appearance (SEA), characterized by nearly symmetrical round high signal intensity lesions located at anterior horns (gray matter) on T2-weighted image.
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Purpose@#To evaluate the association between magnetic resonance imaging (MRI)-based texture parameters and Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation in patients with non-mucinous rectal cancer. @*Materials and Methods@#Seventy-nine patients who had pathologically confirmed rectal nonmucinous adenocarcinoma with or without KRAS-mutation and had undergone rectal MRI were divided into a training (n = 46) and validation dataset (n = 33). A texture analysis was performed on the axial T2-weighted images. The association was statistically analyzed using the Mann-Whitney U test. To extract an optimal cut-off value for the prediction of KRAS mutation, a receiver operating characteristic curve analysis was performed. The cut-off value was verified using the validation dataset. @*Results@#In the training dataset, skewness in the mutant group (n = 22) was significantly higher than in the wild-type group (n = 24) (0.221 ± 0.283; -0.006 ± 0.178, respectively, p = 0.003). The area under the curve of the skewness was 0.757 (95% confidence interval, 0.606 to 0.872) with a maximum accuracy of 71%, a sensitivity of 64%, and a specificity of 78%. None of the other texture parameters were associated with KRAS mutation (p > 0.05). When a cut-off value of 0.078 was applied to the validation dataset, this had an accuracy of 76%, a sensitivity of 86%, and a specificity of 68%. @*Conclusion@#Skewness was associated with KRAS mutation in patients with non-mucinous rectal cancer.
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Anti-myelin oligodendrocyte glycoprotein (anti-MOG) syndrome is an immunemediated inflammatory condition of the central nervous system, which usually involves spinal cord and optic nerves. Herein, we studied the case of a 57-yearold female patient who presented with acute/subacute symptoms of sphincter dysfunction, paraparesis, and ocular pain. The patient was diagnosed with anti-MOG syndrome with findings resembling snake-eye appearance (SEA), characterized by nearly symmetrical round high signal intensity lesions located at anterior horns (gray matter) on T2-weighted image.
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Objective@#Measurement of the liver and spleen volumes has clinical implications. Although computed tomography (CT)volumetry is considered to be the most reliable noninvasive method for liver and spleen volume measurement, it has limitedapplication in clinical practice due to its time-consuming segmentation process. We aimed to develop and validate a deeplearning algorithm (DLA) for fully automated liver and spleen segmentation using portal venous phase CT images in variousliver conditions. @*Materials and Methods@#A DLA for liver and spleen segmentation was trained using a development dataset of portal venousCT images from 813 patients. Performance of the DLA was evaluated in two separate test datasets: dataset-1 which included150 CT examinations in patients with various liver conditions (i.e., healthy liver, fatty liver, chronic liver disease, cirrhosis,and post-hepatectomy) and dataset-2 which included 50 pairs of CT examinations performed at ours and other institutions.The performance of the DLA was evaluated using the dice similarity score (DSS) for segmentation and Bland-Altman 95%limits of agreement (LOA) for measurement of the volumetric indices, which was compared with that of ground truth manualsegmentation. @*Results@#In test dataset-1, the DLA achieved a mean DSS of 0.973 and 0.974 for liver and spleen segmentation, respectively,with no significant difference in DSS across different liver conditions (p = 0.60 and 0.26 for the liver and spleen, respectively).For the measurement of volumetric indices, the Bland-Altman 95% LOA was -0.17 ± 3.07% for liver volume and -0.56 ± 3.78%for spleen volume. In test dataset-2, DLA performance using CT images obtained at outside institutions and our institutionwas comparable for liver (DSS, 0.982 vs. 0.983; p = 0.28) and spleen (DSS, 0.969 vs. 0.968; p = 0.41) segmentation. @*Conclusion@#The DLA enabled highly accurate segmentation and volume measurement of the liver and spleen using portalvenous phase CT images of patients with various liver conditions.
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PURPOSE: To report the follow-up results of percutaneous transluminal angioplasty (PTA) of supra-aortic arteries in patients presenting with neurological manifestations caused by Takayasu's arteritis. MATERIALS AND METHODS: PTA was performed in four consecutive patients (women, age range 33-38 years) with Takayasu's arteritis (TA) with neurological manifestations (i.e., stroke, visual disturbance, and dizziness) caused by stenoocclusive lesions of supra-aortic arteries. RESULTS: PTA was attempted on 5 lesions: VA (n=3), subcalvain artery (n=1), and brachiocephalic artery (n=1). PTA was performed successfully in all patients. The neurological manifestations of the patients were improved after angioplasty. There was no immediate procedure-related complication or neurologic deficits and no restenosis on follow-up angiography in three patients. All patients were neurologically stable without occurrence of further neurological deficit during follow-up periods (9 months - 7 years). CONCLUSION: PTA of supra-aortic arteries in TA is safe and effective and provides good symptomatic relief in some patients with symptomatic multifocal stenoocclusive lesions of arch arteries.
