Fragmentectomy versus Conventional Microdiscectomy in Single-Level Lumbar Disc Herniations : Comparison of Clinical Results and Recurrence Rates

OBJECTIVE: This retrospective study aimed to compare clinical outcomes in terms of pain relief and recurrence rate between fragmentectomies and conventional microdiscectomies in patients with lumbar disc herniation (LDH). METHODS: Between January 2008 and May 2011, a total of 175 patients met the inclusion criteria of this study. The visual analogue scale (VAS) scores of back and radicular pains were recorded before surgery, 2 and 6 weeks after surgery. Recurrence was defined when a patient had the same pattern of preoperative symptoms and was confirmed with magnetic resonance imaging. RESULTS: Seventy-four patients (42.3%) were suitable for fragmentectomy, and 101 patients underwent conventional microdiscectomy. There were no significant differences in VAS scores between the fragmentectomy and conventional microdiscectomy groups 2 and 6 weeks after surgery. During the follow-up period, 3 patients (4.05%) in the fragmentectomy group and 7 patients (6.93%) in the conventional microdiscectomy group relapsed. CONCLUSION: If patients are selected according to well-defined criteria, fragmentectomy can be a good surgical option for LDH, in the physiological aspect of preserving healthy intervertebral disc materials.

Posterior Atlantoaxial Transarticular Screw Fixation

OBJECTIVE: Posterior arthrodesis in atlantoaxial instability has been performed using various posterior C1-2 wiring techniques. Recently, transarticular screw fixation (TASF) technique was introduced to achieve significant immediate stability of the C1-2 joint complex. The purpose of this study is to assess the clinical outcomes associated with posterior C1-2 TASF for the patient of atlantoaxial instability. METHODS: We retrospectively reviewed data obtained from 17 patients who underwent C1-2 TASF and supplemented Posterior wiring technique (PWT) with graft between 1994 and 2005. There were 8 men and 9 women with a mean age of 43.5 years (range, 12-65 years). An average follow-up was 26 months (range, 15-108 months). RESULTS: Successful fusions were achieved in 16 of 17 (94%). The pain was improved markedly (3 patients) or resolved completely (14 patients). There was no case of neurological deterioration, hypoglossal nerve injury, or vertebral artery injury. Progression of spinal deformity, screw pullout or breakage, and neurological or vascular complications did not occur. CONCLUSION: The C1-2 TASF with supplemental wiring provided a high fusion rate. Our result demonstrates that C1-2 TASF supplemented by PWT is a safe and effective procedure for atlantoaxial instability. Preoperative evaluation and planning is mandatory for optimal safety.

Posterior Atlantoaxial Transarticular Screw Fixation

OBJECTIVE: Posterior arthrodesis in atlantoaxial instability has been performed using various posterior C1-2 wiring techniques. Recently, transarticular screw fixation (TASF) technique was introduced to achieve significant immediate stability of the C1-2 joint complex. The purpose of this study is to assess the clinical outcomes associated with posterior C1-2 TASF for the patient of atlantoaxial instability. METHODS: We retrospectively reviewed data obtained from 17 patients who underwent C1-2 TASF and supplemented Posterior wiring technique (PWT) with graft between 1994 and 2005. There were 8 men and 9 women with a mean age of 43.5 years (range, 12-65 years). An average follow-up was 26 months (range, 15-108 months). RESULTS: Successful fusions were achieved in 16 of 17 (94%). The pain was improved markedly (3 patients) or resolved completely (14 patients). There was no case of neurological deterioration, hypoglossal nerve injury, or vertebral artery injury. Progression of spinal deformity, screw pullout or breakage, and neurological or vascular complications did not occur. CONCLUSION: The C1-2 TASF with supplemental wiring provided a high fusion rate. Our result demonstrates that C1-2 TASF supplemented by PWT is a safe and effective procedure for atlantoaxial instability. Preoperative evaluation and planning is mandatory for optimal safety.

Post-traumatic Atlantoaxial Rotatory Dislocation in an Adult Treated by Open Reduction and C1-C2 Transpedicular Screw Fixation

Atlantoaxial rotatory dislocation (AARD) is an uncommon disorder of childhood in which clinical diagnosis is generally difficult and often made late. It is very rare in adults because of the unique biomechanical features of the atlantoaxial articulation. We report a case of post-traumatic AARD in an adult. Reduction was difficult to obtain by skull traction and gentle manipulation. Therefore, the patient was treated surgically by an open reduction, transpedicular screw fixation, and posterior C1-2 wiring with graft. The normal atlantoaxial relation was restored with disappearance of torticollis. Postoperatively, the patient remains neurologically intact and has radiographic documentation of fusion. Atlantoaxial transpedicular screw fixation can be one of the treatment options for the AARD.

Visual Outcome after Surgical Removal of Craniopharyngiomas

OBJECTIVE: In the present study, we evaluate visual outcomes after surgical removal of craniopharyngiomas and analyze the factors that are considered to affect visual outcomes. METHODS: This study includes 30 patients with craniopharyngioma, who underwent surgery in this clinic during the last 10 years. The changes of visual function (visual acuity and field) of the patients were assessed preoperatively and postoperatively, and paired data of this change were compared. Also, the factors that influence on this change were analysed. RESULTS: Among the 21 patients complaining of decreased vision before the operation, 8 patients were improved (38.0%), and 7 patients were worse (33.3%). However, Four out of 9 patients without any preoperative visual symptoms developed worse vision after the operation (44.4%). The average duration of symptom was 17.2 months in the improved group and 23.6 months in the aggravated group. The tumors recurred in only 5 patients after the gross total resection: Four of them showed the aggravation of visual function after surgical removal and 1 had improvement. CONCLUSION: After removal of craniopharyngiomas, the overall rate of vision improvement, no change and aggravation are 26.6%, 36.7% and 36.7%, respectively. Aggravation of postoperative visual function is higher in males, children and patients with a longer duration of symptom and the tumor recurres more frequently in patients who complained of worsened vision after surgical removal.

Reversal of Marrow Fibrosis Following Imatinib Mesylate Therapy in a Patient with Chronic Myelogenous Leukemia Who Was Refractory to Interferon-alpha

No abstract available.

A Case of Infective Endocarditis associtaed with Microcytic Hypochromic Anemia

We experienced a case of infective endocarditis, which unusual has symptoms and microcytic hypochromic anemia. Anemia associated with infective endocarditis is a common manifestation, but is generally normocytic nor-mochromic. However, microcytic hypochromic anemia is an uncommon manifestation of infective endo-carditis, and has only been noted in a few previous reports. We systematically evaluated anemia, and diagnosed fatal underlying diseases, such as infective endocarditis.

Brown Sequard Syndrome Resulting from Cervical Disc Herniation Treated by Anterior Foraminotomy

The authors describe two cases of Brown-Sequard syndrome associated with cervical disc herniation. In both cases, magnetic resonance images of the cervical spine showed a large paramedian disc herniation at C5-C6 with ipsilateral severe spinal cord compression. Microsurgical removal of the herniated disc via anterior foraminotomy was performed and complete decompression of the spinal cord was achieved. Postoperatively, the neurological symptoms recovered rapidly and both patients experienced a complete remission of their symptoms. Although Brown-Sequard syndrome is rarely associated with degenerative cervical spine disease, cervical disc herniation should be kept in mind and prompt evaluations are mandatory. To the best of our knowledge, these are the first reported case of Brown-Sequard syndrome produced by cervical disc herniation which was treated by anterior foraminotomy.

Radiofrequency catheter ablation in idiopathic ventricular tachycardia showing left bundle branch block and inferior axis: the significanece of morphologic variation of R wave on right precordial leads / 대한내과학회지

BACKGROUND: Radiofrequency catheter ablation (RFCA) becomes an useful treatment for idiopathic ventricular tachycardia, especially right ventricular outflow tract ventricular tachycardia (RVOT VT) typically originates from "superior septal" aspect of right ventricular outflow tract. However, some of the right ventricular outflow tachycardias remain resistant despite repeated attempts of RFCA. This study was focused to search the electrocardiographic characteristics suggesting procedural success of radiofrequency ablation in RVOT VT and ventricular tachycardia that can not be ablated by conventional approach confined to right ventricular outflow tract even though to show similar electrocardiographic morphology. METHODS: The study subjects were 25 patients who underwent RFCA with the diagnosis of RVOT VT. We classified the study subjects into 2 groups and in group 1 (N=17, Age 47.5 +/- 16.8) in those successful RFCA was possible in RVOT. In group 2 (N=8, Age 54.8 +/- 8.0), the removal of VT was not possible with the RFCA confined in RVOT. We analyzed the morphologic characteristics of QRS complex of VT or ventricular premature beats in right precordial leads; V(1-3). The QRS and R wave duration, height of R wave, depth of S wave, R/S ratio and R wave duration index were measured. RESULTS: There was no difference of age and sex between group 1 and 2 (Group 1: N=17, Male 29.4%, Age 49.5 +/- 16.8 vs Group 2: N=8, Age 54.8 +/- 8.0, Male 37.5%). The maximal QRS duration in V(1-3) was 144.2 +/- 23.6 ms in group 1 and 136.3 +/- 25.1 ms in group 2. The R wave duration and R wave duration index were not different either between group 1 and 2. However, the R wave duration of lead V 3 in group 2 was 97.0 +/- 34.4 ms and significantly longer than 65.0 +/- 26.0 msec in Group 1 (p=0.04). R wave duration index also showed significant difference between two groups: 72.0 +/- 23.5% of group 2 vs 45.4 +/- 17.8% of group 1. In comparison of R wave height and depth of S wave in V(1-3) between two groups, the R/S ratio of lead V3 in group 2 showed the ratio of 343.4 +/- 227.7% which was significantly larger than 97.4 +/- 92.2% in group 1. CONCLUSION: For the practice of RFCA for RVOT VT, morphologic characterstics of VT or VPC showing wide R wave and high R/S wave ratio in precordial leads, especially in V3 could be an useful electrocardiographic indicator to suspect the unusual focus of idiopathic VT showing inferior axis and LBBB pattern.

Three Cases of Intracranial Clear Cell Meningioma

The clear cell meningioma(CCM) is a rare and recently described as a histologic variant of meningioma. It has been identified and included in new World Health Organization(WHO) classification of the Central Nervous System(CNS) tumors recently. The CCMs are histologically characterized by sheets of spindled to polygonal cells with clear cytoplasm, which is the expression of high glycogen concentration. The CCMs occur in younger patients and usually are located in the spinal canal and posterior fossa. The most interesting aspect of CCM is the high recurrence rate and aggressiveness. Poor outcome has been shown in intracranial and spinal tumor location, but the indicators that predict outcome have not been established. Until now 22 intracranial CCM cases had been reported in English literature and 3 cases in Korean. The authors report two cases of CCM located at cerebral convexity and one at cavernous sinus those were totally removed (Simpson Grade I~II) by subfrontal, frontal and orbitocranial approaches. The clinical, radiological, histopathological, and neurosurgical features of these cases are discussed with the relevant literatures.

A Case of Cryptococcal Meningitis Developed after Short-term Therapy of Steroid in a Patient with Autoimmune Hemolytic Anemia / 대한혈액학회지

Cryptococcus neoformans commonly causes opportunistic infection in other immunocompromised patients as well as in AIDS. Among cryptococcosis, cryptococcal meningitis is a relatively frequent manifestation and causes serious morbidity and mortality. It needs urgent diagnosis and effective antifungal therapy. We experienced cryptococcal meningitis in a 25-year-old female patient with autoimmune hemolytic anemia. She was admitted because of autoimmune hemolytic crisis. Her anemic symptoms were controlled by steroid and red cell transfusions. However, she was suddenly readmitted with decreased mentality. Seven days later, she was diagnosed as cryptococcal meningitis and cryptococcemia resulting from culture studies of CSF and blood. Since treated with amphotericin B and flucytosine and maintained with prudent fluconazole therapy, her symptoms and general conditions were improved. We report an unusual case of cryptococcal meningitis developed in a patient with autoimmune hemolytic anemia in spite of short-term steroid therapy.