RESUMO
OBJECTIVE: To assess the quality of life of 3 types of chronic hepatitis B before and after the treatment of lamivudine, and to find an ideal way of medical treatment for chronic hepatitis B. METHODS: One hundred and fifty patients with chronic hepatitis B were investigated in this study, among whom 5 1 were in mild state illness, 53 were middle-range and the other 46 were severe. The quality of life of the patients was assessed by the quality of life questionnaire (SF-36). The marks of questionnaire were compared before and after the use of lamivudine to assess its comprehensive curative effect on chronic hepatitis B. RESULTS: The total score of SF-36, score of physical function, role-physical, mental health, social function, bodily pain and vitality were significant different before and after the treatment. Statistically significant differences were found among the 3 types of chronic hepatitis B before and after the treatment. CONCLUSION: The quality of life of patients with chronic hepatitis B can be improved by using lamivudine. Assessment of quality of life may be taken as an important index in treating chronic hepatitis B.
Assuntos
Hepatite B Crônica/tratamento farmacológico , Lamivudina/uso terapêutico , Qualidade de Vida , Feminino , Hepatite B Crônica/psicologia , Humanos , Masculino , Inibidores da Transcriptase Reversa/uso terapêutico , Inquéritos e QuestionáriosRESUMO
OBJECTIVE: To detect hot point mutations of ATP7B gene in Hunan Han patients with Wilson' disease (WD). METHODS: The genomic DNA of 22 WD patients was extracted and exons 5, 8, 12, 13 were amplified by PCR. Screening for the mutations was done by direct sequencing and analysed by BLAST. RESULTS: Fifteen of the 22 patients were found with mutations. Ten heterozygous Arg778Leu (2273G --> T) mutations were found in exon 8, all of them were accompanied with 2250C --> G polymorphism (Leu770Leu). Seven patients were found with 2855G --> A (Arg952Lys) polymorphism (4 heterozygous and 3 homozygous), 3 of them had Arg778Leu mutation in exon 8 and one with heterozygous mutation Gly943Asp (2828G --> A) in exon 12 simultaneously. Only one patient was found with heterozygous Pro992Leu (2975C --> T) mutation in exon 13. No mutations were found in exon 5. CONCLUSION: Arg778Leu is the hot point mutation of ATP7B gene in Hunan Han patients with Wilson' disease while exon 5 is not.
Assuntos
Adenosina Trifosfatases/genética , Proteínas de Transporte de Cátions/genética , Degeneração Hepatolenticular/genética , Mutação , Adolescente , Povo Asiático/genética , Criança , ATPases Transportadoras de Cobre , DNA/genética , Análise Mutacional de DNA , Éxons , Degeneração Hepatolenticular/etnologia , HumanosRESUMO
OBJECTIVE: To survey the sexual sense and AIDS knowledge and to evaluate the instant effect of health education for university students in Changsha. METHODS: According to the KABP survey, 235 students in 2 universities in Changsha were investigated by anonymous questionnaires before and after the health education. The health education on sex and AIDS knowledge was carried out by a professor from an AIDS laboratory. Three hundred and eighty-eight pre- or post-educational questionnaires were analyzed and compared. RESULTS: Some of the students accepted such behaviors as unmarriage sexual act, multipartners, homosexuality, and commercial sexual act. These sexual senses were not instantly corrected by the health education. Most of the students investigated had some AIDS knowledge and the knowledge was improved instantly by the health education. CONCLUSION: There may be some high risk factors for AIDS transmission and venereal disease which may not be corrected by instant education among some university students in Changsha, whereas sexual hygiene and AIDS knowledge of most of the students investigated can be improved by a short-term education, which can be considered as a major form of health education.
