[Coxsackievirus A group 16 strain].

Coxsackievirus A group 16 strain (CVA16) is one of the predominate causative agent of the hand, foot and mouth disease (HFHD). It is very helpful to improve the hand, foot and mouth disease and other associated diseases control and prevention by understanding its biological characteristics, pathogenic mechanism and clinical manifestations, laboratory diagnoses, epidemiology and molecular epidemiology. In the future, we should continue to emphasize the study, improve the diagnostic method and develop vaccine of CVA16. A sound monitoring network of both epidemiology and laboratory will be estabished as well, which can contribute to predicting and prewarning the epidemic conditions of CVA16, and is much important scientific tools for preventing the hand, foot and mouth disease associated with CVA16.

[Seroepidemical study of Coxsackievirus A 16, in four provinces, China, 2005].

OBJECTIVE: To study the situation of 1- 5-years-old children's antibody against Coxsackievirus A group 16 strain (CVA16) in Guangdong, Heilongjiang,Yunnan Province and Xinjiang Uygur Autonomous Regions, China, 2005, it can offer scientific evidences for preventing and controlling CVA16 causative hand-food and mouth disease. METHODS: Using microneutrilization test, to study 503 serum samples randomly selected from sera collected in 2005. RESULTS: Positive rate of anti-CVA16 antibody were 41.90%, 9.40%, 40.00% and 34.40% in Guangdong, Heilongjiang,Yunnan and Xinjiang, respectively. Antibody titer was relative low (average, 1: 6.1) and there was no statistical difference of geometry mean of antibody titer (GMT) among Guangdong, Heilongjiang, Yunnan (F = 0.97, 0.40, 1.06, respectively; P > 0.05), while there had statistical difference of GMT between Heilongjiang and other three regions( F = 10.61, P < 0.00). CONCLUSIONS: There had probably existed local epidemic in some regions of Guangdong, Heilongjiang, Yunnan Province and Xinjiang Uygur Autonomous Regions, China, 2005 or even before, but the area and degree of transmission and epidemic had difference. Children aged from 1- 5-years-old were relatively susceptible population of CVA16 infection.