RESUMO
BACKGROUND: The objective of this study was to determine whether severity and severity change of coexisting psychiatric symptoms might affect change of complicated grief (CG) regarding the Sewol ferry disaster. METHODS: Data from a cross-sectional survey were obtained 18 months (Time 1) and 30 months (Time 2) after the disaster. We ascertained sociodemographic variables and variables obtained from self-reporting questionnaires (i.e., CG, depression, anxiety, post-traumatic stress disorder [PTSD], insomnia, embitterment, and suicidal risk) among 56 bereaved family members. RESULTS: Severity of other psychiatric symptoms at Time 1 had no effect on change of CG at Time 2. However, changes in severity of PTSD over a year affected change of CG. CONCLUSION: It is important to evaluate changes in severity of PTSD and its treatment during management of CG, especially when it involves bereaved families experiencing a traumatic accident.
Assuntos
Família/psicologia , Pesar , Transtornos de Estresse Pós-Traumáticos/patologia , Adulto , Idoso , Estudos Transversais , Desastres , Feminino , Seguimentos , Humanos , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Autorrelato , Índice de Gravidade de Doença , Inquéritos e Questionários , Adulto JovemRESUMO
A series of pyrimidine derivatives as acid pump antagonists (APAs) was synthesized and the inhibitory activities against H(+)/K(+) ATPase isolated from hog gastric mucosa were determined. After elaborating on substituents at C2 and C4 position of the pyrimidine scaffold, we have observed that the compound 7h is a potent APA with H(+)/K(+) ATPase, IC(50) = 52 nM.
Assuntos
Inibidores Enzimáticos/química , Isoquinolinas/química , Inibidores da Bomba de Prótons , Pirimidinas/química , Animais , Inibidores Enzimáticos/síntese química , Inibidores Enzimáticos/farmacologia , Mucosa Gástrica/enzimologia , ATPase Trocadora de Hidrogênio-Potássio/metabolismo , Isoquinolinas/síntese química , Isoquinolinas/farmacologia , Cinética , Pirimidinas/síntese química , Pirimidinas/farmacologia , Relação Estrutura-Atividade , SuínosRESUMO
A series of 1H-pyrrolo[2,3-c]pyridines as acid pump antagonists (APAs) was synthesized and the inhibitory activities against H(+)/K(+) ATPase isolated from hog gastric mucosa were determined. After elaborating on substituents at N1, C5, and C7 position of 1H-pyrrolo[2,3-c]pyridine scaffold, we have observed that compounds 14f and 14g are potent APAs with H(+)/K(+) ATPase IC(50)=28 and 29 nM, respectively.