RESUMO
Previous studies have suggested that hepatic arterial flow in heterotopic partial liver transplants is necessary to ensure graft survival and regenerative capacity. This report presents findings in a syngeneic rat strain (Lewis) that partial liver transplants can be successfully heterotopically transplanted in the long term with the only inflow coming from the portal vein. When the host liver undergoes a nearly complete resection at 3-4 weeks, the transplanted liver regenerates to maintain the health of the host. Moderate to massive hepatocellular necrosis occurs in the first 3 months postoperatively, with recovery by 4-5 months. Liver transplants 8-10 months postoperatively appear architecturally normal. No host liver tissues were found to be regenerating after subtotal host liver resection. We conclude that portal vein reconstruction without hepatic arterial inflow can sustain a partial liver transplant in the long term, replacing the function of the host liver.
Assuntos
Transplante de Fígado/métodos , Fígado/irrigação sanguínea , Veia Porta/fisiologia , Transplante Heterotópico/métodos , Anastomose Cirúrgica/métodos , Animais , Hepatectomia , Fígado/patologia , Regeneração Hepática , Transplante de Fígado/patologia , Masculino , Microcirurgia/métodos , Veia Porta/cirurgia , Período Pós-Operatório , Ratos , Ratos Endogâmicos Lew , Técnicas de Sutura , Fatores de Tempo , Transplante Heterotópico/patologia , Resultado do TratamentoRESUMO
Since adjuvant radiotherapy for rectosigmoid carcinoma appears to improve prognosis, the importance of delayed side effects such as radiation-induced malignant disease must be considered. The present report describes the first reported case of the development of a uterine carcinosarcoma more than 9 years after preoperative radiotherapy to the midpelvis for rectal carcinoma.
