RESUMO
The Guanine-nucleotide binding protein 2 (GNB2) encodes for ß2 subunit (Gß2) of the G-protein complex. Keeping in view the increased demand of reliable biomarkers in cancer, the current study was planned to extensively explored GNB2 expression variation and its roles in different cancers using online available databases and diverse methodology. In view of our results, the GNB2 was notably up-regulated relative to corresponding controls in twenty three cancer types. As well, the elevated expression of GNB2 was found to be associated with the reduced overall survival (OS) of the Liver Hepatocellular Carcinoma (LIHC) and Rectum Adenocarcinoma (READ) only out of all analyzed cancer types. This implies GNB2 plays vital role in the tumorigenesis of LIHC and READ. Several additional analysis also explored six critical pathways and few important correlations related to GNB2 expression and different other parameters such as promoter methylation, tumor purity, CD8+ T immune cells infiltration, and genetic alteration, and chemotherapeutic drugs. In conclusion, GNB2 gene has been identified in this study as a shared potential biomarker (diagnostic and prognostic) of LIHC and READ.
Assuntos
Carcinoma Hepatocelular , Neoplasias Hepáticas , Carcinoma Hepatocelular/genética , Carcinoma Hepatocelular/patologia , Proteínas de Ligação ao GTP/genética , Guanina , Humanos , Neoplasias Hepáticas/genética , Neoplasias Hepáticas/patologia , MutaçãoRESUMO
We prospectively studied acute Achilles tendon rupture in patients over a two 2-year period and reviewed the causes, outcome and complications. There were 53 patients included with acute Achilles rupture with minimum follow up period of 6 months. We compared the outcomes including infection rate and Boyden score between the two groups repaired by Polydioxanone and Polyester respectively. All infected cases had a suture repair using the polyester suture. The difference in the infection rate was highly significant between the 2 groups (p=0.001). All 34 patients (100%) in the PDS group had good / excellent results based on the Boyden clinical assessment. Conversely, only 16 patients 9(68.4%) had good or excellent results IN Polyester repair group. Patients treated with a non- absorbable suture (ethibond) material for repair had a higher incidence infection and worse Boyden scores than the absorbable PDS group.
Assuntos
Tendão do Calcâneo/lesões , Polidioxanona , Polietilenotereftalatos , Ruptura/cirurgia , Infecção da Ferida Cirúrgica/etiologia , Suturas/efeitos adversos , Humanos , Estudos ProspectivosRESUMO
A rare case of unilateral benign essential tremor is presented that responded to surgical excision of a posterior fossa arachnoid cyst.
Assuntos
Cistos Aracnóideos/complicações , Tremor Essencial/etiologia , Adulto , Cistos Aracnóideos/diagnóstico , Cistos Aracnóideos/cirurgia , Fossa Craniana Posterior , Feminino , Humanos , Imageamento por Ressonância Magnética , Resultado do TratamentoRESUMO
A rare case of vesical calculi complicating the procedure of ventriculo-vesical shunt is presented. In addition to highlighting technical difficulties in placing shunt catheters into the urinary system, the potential complications are discussed. We consider this route of cerebrospinal fluid(CSF) diversion less physiological compared with the peritoneal, pleural or the venous sites, and discourage use of the urinary bladder as the drainage site for the shunting of CSF.
Assuntos
Derivações do Líquido Cefalorraquidiano/efeitos adversos , Cálculos da Bexiga Urinária/etiologia , Adulto , Derivações do Líquido Cefalorraquidiano/instrumentação , Falha de Equipamento , Humanos , MasculinoRESUMO
A case of recurrent intracranial abscess at the initial site after a latency of 16 years is presented. The causes and possible mechanisms of recurrence are discussed.
Assuntos
Abscesso Encefálico/tratamento farmacológico , Idoso , Antibacterianos/uso terapêutico , Abscesso Encefálico/diagnóstico por imagem , Abscesso Encefálico/etiologia , Confusão/etiologia , Cefaleia/etiologia , Humanos , Masculino , Paresia/etiologia , Recidiva , Distúrbios da Fala/etiologia , Tomografia Computadorizada por Raios X/métodosAssuntos
Arteriopatias Oclusivas/complicações , Doenças das Artérias Carótidas/complicações , Artéria Carótida Interna , Aneurisma Intracraniano/complicações , Artéria Cerebral Posterior , Idoso , Arteriopatias Oclusivas/diagnóstico por imagem , Doenças das Artérias Carótidas/diagnóstico por imagem , Artéria Carótida Interna/diagnóstico por imagem , Angiografia Cerebral , Humanos , Aneurisma Intracraniano/diagnóstico por imagem , Masculino , Artéria Cerebral Posterior/diagnóstico por imagem , Tomografia Computadorizada por Raios XRESUMO
The authors present four patients with a history of high dose cranial irradiation, who were diagnosed years later to have symptomatic meningiomas requiring surgical management. Relevant literature pertaining to these rare tumours is reviewed and their unusual characteristics highlighted. Their aetio-pathogenesis and management strategies are discussed.
Assuntos
Irradiação Craniana/efeitos adversos , Neoplasias Meníngeas/etiologia , Meningioma/etiologia , Neoplasias Induzidas por Radiação/etiologia , Adulto , Idade de Início , Idoso , Deleção Cromossômica , Cromossomos Humanos Par 22/genética , Feminino , Humanos , Masculino , Neoplasias Meníngeas/genética , Neoplasias Meníngeas/prevenção & controle , Meningioma/genética , Meningioma/prevenção & controle , Neoplasias Induzidas por Radiação/genética , Neoplasias Induzidas por Radiação/prevenção & controle , Estudos RetrospectivosRESUMO
Intraspinal pneumocoele is rarely associated with closed head injury. We describe a case of intra-spinal pneumocoele following a closed head injury. We believe this to be the first case presenting with radicular symptoms.
