Exploration of the associations of touch-screen tablet computer usage and musculoskeletal discomfort.

BACKGROUND: Tablet users may be at high risk of developing physical discomfort because of their usage behaviors and tablet design. OBJECTIVE: Investigate the usage of tablets, variations in head and neck posture associated with different tablet tilt angles, and the association of tablet use with users' musculoskeletal discomfort. METHODS: A survey of users' subjective perceptions conducted by questionnaire and measurements of users' postures by a 3D Motion analysis system was used to explore the effects of tablet use. RESULTS: The questionnaire results indicated that over half of the participants reported physical discomfort after using tablets, with the most prevalent discomfort in the neck and shoulders, and more intensity of discomfort for the back although only few participants experienced it. Chi-squared tests indicated that significantly more participants who tended to use tablet computers to play games reported having musculoskeletal discomfort after using a tablet. In addition, preferences for tablet tilt angles varied across tasks (reading and game playing). The results from the 3D motion analysis revealed that head and neck flexion angles were significantly reduced when the tablets were positioned at relatively steep tilt angles. Neck flexion angle was significantly higher in game playing. CONCLUSIONS: These data add information regarding to the usage of tablet and its associations with physical discomfort (significantly more participants who tended to use tablet computers to play games reported having musculoskeletal discomfort after using a tablet). Steep tilt angles (such as 60°) may cause tablet users to decrease their head and neck flexion angles, which could lead to a more neutral, effortless, and ergonomically correct posture. Maintaining proper neck posture during active activities such as game playing is recommended to avoid neck discomfort.

The genomic landscape of juvenile myelomonocytic leukemia.

Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative neoplasm (MPN) of childhood with a poor prognosis. Mutations in NF1, NRAS, KRAS, PTPN11 or CBL occur in 85% of patients, yet there are currently no risk stratification algorithms capable of predicting which patients will be refractory to conventional treatment and could therefore be candidates for experimental therapies. In addition, few molecular pathways aside from the RAS-MAPK pathway have been identified that could serve as the basis for such novel therapeutic strategies. We therefore sought to genomically characterize serial samples from patients at diagnosis through relapse and transformation to acute myeloid leukemia to expand knowledge of the mutational spectrum in JMML. We identified recurrent mutations in genes involved in signal transduction, splicing, Polycomb repressive complex 2 (PRC2) and transcription. Notably, the number of somatic alterations present at diagnosis appears to be the major determinant of outcome.

Effect of assistive reading software on high school students with learning disabilities: a pilot study.

OBJECTIVE: This research project was designed to test the immediate effect of using assistive reading software - Kurzweil 3000 (K-3000) for high school students with learning disabilities (LD) to improve their English reading and other school performances. PARTICIPANTS: 29 Taiwanese high school students with LD were randomly assigned to one of two groups: (1) use of the K-3000 or (2) control group (using a pen and paper). METHODS: Both groups were asked to complete the standardized measurements using pen and paper a pre-test. Students in experiment group used the K-3000 to do the post-test after they were familiarized with the K-3000, while the students in the control group used pen and paper for the post-test. The differences between the pre-test and post-test of two groups were analyzed. RESULTS: The results suggested that the K-3000 had an immediate impact on students' English word recognition and pronunciation. However, the use of K-3000 did not have a significant influence on the students' general English proficiency, learning adjustment, and academic self-perception. CONCLUSIONS: The use of K-3000 had a positive effect on students' English word recognition. The reason why there was no significant change in students' other performances could be due to the length of the intervention.

Perceptions of a computer-based instruction system in special education: high school teachers and students views.

OBJECTIVE: Researchers investigated how one type of computer-based instruction (CBI)--Kurzweil 3000 (K-3000), was perceived to affect the reading, functional task performance, and academic self-perception of high school students with special needs. PARTICIPANTS: 16 students with special needs used K-3000 (assistive software that provides students with reading support) for six months to read assignments for their English language arts class and six teachers who had previous experience with integrating K-3000 into their classes were recruited. METHODS: Data from focus group interviews of students and teachers were used. The advantages and disadvantages of K-3000, the factors that affected teachers' use of CBI and users' progress were explored. RESULTS: After the regular use of K-3000, students and teachers reported improvement in the amount and speed of reading and increased academic self-perception, specifically related to reading comprehension and pronunciation. Teachers reported that lack of accessibility to technology, time constraints, and difficulties with class management were the major reasons that hindered CBI use in their classrooms. CONCLUSIONS: Student participants noted that CBI was helpful when they were engaged in functional activities related to reading and writing. The progress of students in self-perception, and the advantages and drawbacks of the K-3000, along with the mechanism of users' progression were described and discussed.