RESUMO
We demonstrate an intrinsic antitumor effect of polymer nanoparticles (P-NPs), which could re-program tumor-associated macrophages to pro-inflammatory phenotype. The intrinsic effect of P-NPs on macrophage repolarization and its combination with other therapies provide new ideas for drug delivery, macrophage regulation and immunotherapy in cancer treatment.
Assuntos
Antineoplásicos/farmacologia , Ativação de Macrófagos/efeitos dos fármacos , Macrófagos/efeitos dos fármacos , Maleatos/farmacologia , Nanopartículas/química , Poliestirenos/farmacologia , Polivinil/farmacologia , Animais , Antineoplásicos/química , Antineoplásicos/toxicidade , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Ensaios de Seleção de Medicamentos Antitumorais , Maleatos/química , Maleatos/toxicidade , Camundongos , Nanopartículas/toxicidade , Poliestirenos/química , Poliestirenos/toxicidade , Polivinil/química , Polivinil/toxicidadeRESUMO
Owing to the accumulation of high concentrations of antibiotics in the environment, antibiotic resistance has become a serious public health threat to modern society. Herein, developing antibiotic agents that could be externally inactivated for preventing bacterium from exposing to antibiotics continuously is highly desirable. We design and synthesize a photoresponsive, broad-spectrum antibiotic (azobenzene-norfloxacin), the antibacterial activity of azobenzene-norfloxacin can be "turned off" with light irradiation due to the conformation change of azobenzene, followed by minimizing the buildup of active antibiotics in the environment. This agent capable of inactivation exhibits potential to avoid the occurrence of antibiotic-resistant bacterial strains.