Effects of technical-tactical skills on enhancing scoring efficiency when competing with opponents using different handedness in table tennis matchups.

Technical-tactical skills are key to determining table tennis match performance. Identifying the skills that can increase scoring probability when competing against opponents with different racket handedness is vital. The aim of this study was to investigate the technical-tactical actions that could significantly improve scoring efficiency in SH (same-handedness) matches and OH (opposite-handedness) matches. The statistics of 72 top-level men's singles matches were collected (40 SH matches and 32 OH matches). An independent samples t-test was performed to evaluate the differences in the scoring efficiency of the point-winning shot. The results showed that the following maneuvers were crucial technical-tactical skills to increase scoring probability: (1) during the mutual-restriction phase, executing a forehand short push to forehand during service round and a backhand long push to backhand during receiving round against SH opponents (p < 0.05, ES: 0.59-0.70), and a backhand short push to middle in receiving round against OH opponents (p < 0.01, ES = 0.66); (2) during the initial-attack-and-counterattack phase, performing an initial forehand flip and a loop (drive) to forehand, a counter backhand loop (drive) to backhand during both types of rounds, and a forehand block (lob) to forehand during service round against SH opponents (p < 0.05, ES: 0.52-1.18), and an initial forehand loop (drive) to backhand and a counter backhand loop (drive) to forehand during both types of rounds, an initial forehand flip and a loop (drive) to backhand during service round, and an initial backhand flip to middle during receiving round against OH opponents (p < 0.05, ES: 0.45-0.99); and (3) during the topspin-exchange phase, hitting a forehand loop (drive) to forehand during service round and a backhand loop (drive) to backhand during both types of rounds against SH opponents (p < 0.05, ES: 0.51-1.32), a forehand loop (drive) to backhand during both types of rounds against OH opponents (p < 0.01, ES: 0.77-0.91). Professionals are recommended to concentrate on the enhancement of the abovementioned key technical-tactical skills to achieve better match performance.

(-)-Epigallocatechin-3-gallate, a Polyphenol from Green Tea, Regulates the Liquid-Liquid Phase Separation of Alzheimer's-Related Protein Tau.

The microtubule-associated protein tau is involved in Alzheimer's disease and other tauopathies. Recently, tau has been shown to undergo liquid-liquid phase separation (LLPS), which is implicated in the physiological function and pathological aggregation of tau. In this report, we demonstrate that the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) promotes the formation of liquid tau droplets at neutral pH by creating a network of hydrophobic interactions and hydrogen bonds, mainly with the proline-rich domain of tau. We further show that EGCG oxidation, tau phosphorylation, and the chemical structure of the polyphenol influence the efficacy of EGCG in facilitating tau LLPS. Complementary to the inhibitory activity of EGCG in tau fibrillization, our findings provide novel insights into the biological activity of EGCG and offer new clues for future studies on the molecular mechanism by which EGCG alleviates neurodegenerative diseases.

Interactive Three-Phase Structure for Table Tennis Performance Analysis: Application To Elite Men's Singles Matches.

The aim of the current study was twofold: (a) to construct an Interactive Three-Phase Structure for table tennis performance analysis and (b) to apply the proposed structure to the performance analysis of elite men's singles matches. The current structure makes improvements over the former ones in the following aspects: more comprehensive performance variables consisting of bilateral actions covering the whole rally competing process, a better phase division method fitting to the real match situation and more focused analysis achieved by the designed critical phase. The analysis of 56 elite men's singles matches (5507 rallies) was conducted using the proposed structure. The results demonstrated that performance variables of the rally competing process ceasing in Phase 2 (initial attack and counterattack phase) were decisive for the rally outcome of elite men's singles matches. The proposed structure provides practitioners with a better model to enhance the effectiveness of table tennis performance analysis.

The Value of Admission Serological Indicators for Predicting 28-Day Mortality in Intensive Care Patients With Acute Heart Failure: Construction and Validation of a Nomogram.

Background: Acute heart failure (AHF) is a severe clinical syndrome characterized as rapid onset or worsening of symptoms of chronic heart failure (CHF). Risk stratification for patients with AHF in the intensive care unit (ICU) may help clinicians to predict the 28-day mortality risk in this subpopulation and further raise the quality of care. Methods: We retrospectively reviewed and analyzed the demographic characteristics and serological indicators of patients with AHF in the Medical Information Mart for Intensive Care III (MIMIC III) (version 1.4) between June 2001 and October 2012 and our medical center between January 2019 and April 2021. The chi-squared test and the Fisher's exact test were used for comparison of qualitative variables among the AHF death group and non-death group. The clinical variables were selected by using the least absolute shrinkage and selection operator (LASSO) regression. A clinical nomogram for predicting the 28-day mortality was constructed based on the multivariate Cox proportional hazard regression analysis and further validated by the internal and external cohorts. Results: Age > 65 years [hazard ratio (HR) = 2.47], the high Sequential Organ Failure Assessment (SOFA) score (≥3 and ≤8, HR = 2.21; ≥9 and ≤20, HR = 3.29), lactic acid (Lac) (>2 mmol/l, HR = 1.40), bicarbonate ( HCO 3 - ) (>28 mmol/l, HR = 1.59), blood urea nitrogen (BUN) (>21 mg/dl, HR = 1.75), albumin (<3.5 g/dl, HR = 2.02), troponin T (TnT) (>0.04 ng/ml, HR = 4.02), and creatine kinase-MB (CK-MB) (>5 ng/ml, HR = 1.64) were the independent risk factors for predicting 28-day mortality of intensive care patients with AHF (p < 0.05). The novel nomogram was developed and validated with a promising C-index of 0.814 (95% CI: 0.754-0.882), 0.820 (95% CI: 0.721-0.897), and 0.828 (95% CI: 0.743-0.917), respectively. Conclusion: This study provides a new insight in early predicting the risk of 28-day mortality in intensive care patients with AHF. The age, the SOFA score, and serum TnT level are the leading three predictors in evaluating the short-term outcome of intensive care patients with AHF. Based on the nomogram, clinicians could better stratify patients with AHF at high risk and make adequate treatment plans.

Admission Blood Glucose Is Associated With the 30-Days Mortality in Septic Patients: A Retrospective Cohort Study.

Background: Sepsis, as one of the severe diseases, is frequently observed in critically ill patients, especially concurrent with diabetes. Whether admission blood glucose is associated with the prognosis, and outcome of septic patients is still debatable. Methods: We retrospectively reviewed and analyzed the demographic characteristics of septic patients in the Medical Information Mart for Intensive Care III (MIMIC III, version 1.4) between June 2001 and October 2012. The Chi-square and Fisher's exact tests were used for the comparison of qualitative variables among septic patients with different glucose levels and the 30-day mortality in septic patients with diabetes or not. Univariate and stepwise multivariate Cox regression analyses were used to determine the risk factors for 30-day mortality. Kaplan-Meier analysis was conducted to reveal the different 30-day survival probabilities in each subgroup. Results: A total of 2,948 septic patients (910 cases with diabetes, 2,038 cases without diabetes) were ultimately included in the study. The 30-day mortality was 32.4% (956/2,948 cases) in the overall population without any difference among diabetic and non-diabetic septic patients (p = 1.000). Admission blood glucose levels <70 mg/dl were only observed to be significantly associated with the 30-day mortality of septic patients without diabetes (hazard ratio (HR) = 2.48, p < 0.001). After adjusting for confounders, age >65 years (HR = 1.53, p = 0.001), the Sequential Organ Failure Assessment (SOFA) score >5 (HR = 2.26, p < 0.001), lactic acid >2 mmol/L (Lac, HR = 1.35, p = 0.024), and platelet abnormality (<100 k/ul: HR = 1.49; >300 k/ul: HR = 1.36, p < 0.001) were the independent risk factors for 30-day mortality in septic patients with diabetes. In non-diabetes population, age >65 years (HR = 1.53, p < 0.001), non-White or non-Black patients (HR = 1.30, p = 0.004), SOFA score >5 (HR = 1.56, p < 0.001), blood glucose <70 mg/dl (HR = 1.91, p = 0.003), anion gap (AG) >2 mmol/L (HR = 1.60, p < 0.001), Lac (HR = 1.61, p < 0.001), urea nitrogen >21 mg/dl (HR = 1.45, p = 0.001), alanine aminotransferase (ALT, HR = 1.31, p = 0.009), total bilirubin >1.2 mg/dl (HR = 1.20, p = 0.033), and low hemoglobin (HR = 1.34, p = 0.001) were the independent risk factors for 30-day mortality. Conclusions: Our results indicate admission blood glucose, especially in terms of <70 mg/dl, is the key signaling in predicting the worse 30-day survival probability of septic patients without diabetes, which could help clinicians to make a more suitable and precise treatment modality in dealing with septic patients.