Preparation of a Carbon Doped Tissue-Mimicking Material with High Dielectric Properties for Microwave Imaging Application.

In this paper, the oil-in-gelatin based tissue-mimicking materials (TMMs) doped with carbon based materials including carbon nanotube, graphene ink or lignin were prepared. The volume percent for gelatin based mixtures and oil based mixtures were both around 50%, and the doping amounts were 2 wt %, 4 wt %, and 6 wt %. The effect of doping material and amount on the microwave dielectric properties including dielectric constant and conductivity were investigated over an ultra-wide frequency range from 2 GHz to 20 GHz. The coaxial open-ended reflection technology was used to evaluate the microwave dielectric properties. Six measured values in different locations of each sample were averaged and the standard deviations of all the measured dielectric properties, including dielectric constant and conductivity, were less than one, indicating a good uniformity of the prepared samples. Without doping, the dielectric constant was equal to 23 ± 2 approximately. Results showed with doping of carbon based materials that the dielectric constant and conductivity both increased about 5% to 20%, and the increment was dependent on the doping amount. By proper selection of doping amount of the carbon based materials, the prepared material could map the required dielectric properties of special tissues. The proposed materials were suitable for the phantom used in the microwave medical imaging system.

Design, manufacture and in-vitro evaluation of a new microvascular anastomotic device.

INTRODUCTION: Many microvascular anastomoses have been proposed for use with physical assisted methods, such as cuff, ring-pin, stapler, clip to the anastomose blood vessel. The ring-pin type anastomotic device (e.g., 3M Microvascular Anastomotic System) is the most commonly used worldwide because the anastomotic procedure can be conducted more rapidly and with fewer traumas than using sutures. However, problems including vessel leakage, ring slippage, high cost and high surgical skill demand need to be resolved. The aim of this study is to design and manufacture a new anastomotic device for microvascular anastomosis surgery and validate the device functions with in-vitro testing. METHODS: The new device includes one pair of pinned rings and a set of semi-automatic flap apparatus designed and made using computer-aided design / computer-aided manufacture program. A pair of pinned rings was used to impale vessel walls and establish fluid communication with rings joined. The semi-automatic flap apparatus was used to assist the surgeon to invert the vessel walls and impale onto each ring pin, then turning the apparatus knob to bring the rings together. The device was revised until it became acceptable for clinical requires. An in-vitro test was performed using a custom-made seepage micro-fluid system to detect the leakage of the anastomotic rings. The variation between input and output flow for microvascular anastomoses was evaluated. RESULTS: The new microvascular anastomotic device was convenient and easy to use. It requires less time than sutures to invert and impale vessel walls onto the pinned rings using the semi-automatic flap apparatus. The in-vitro test data showed that there were no tears from the joined rings seam during the procedures. CONCLUSIONS: The new anastomotic devices are effective even with some limitations still remaining. This device can be helpful to simplify the anastomosis procedure and reduce the surgery time.

Design optimisation and experimental evaluation of dorsal double plating fixation for distal radius fracture.

This study determines the relative effects of changes in osteoporosis condition, plate/screw design factors (plate angle/length/width/thickness and screw diameter) and fixation methods (screw number and screw length) on the biomechanical response of dorsal double plating (DDP) fixation at a distal radius fracture to determine the optimal design and evaluate its biomechanical strength using the dynamic fatigue test. Eighteen CAD and finite element (FE) models corresponding to a Taguchi L18 array were constructed to perform numerical simulations to simulate the mechanical responses of a DDP fixed in a simply distal radius fracture bone. The Taguchi method was employed to determine the significance of each design factor in controlling bone/plate/screw stress and distal fragment displacement under axial (100 N), bending (1 N m) and torsion (1 N m) loads. Simulation results indicated that the order rank to determine the mechanical response was the plate thickness, plate width, screw diameter, and number of screws. Dorsal intermediate (L) plate with 60 mm length, 1.8 mm thickness, 6.0 mm width and 2.8 mm diameter, 20 mm length dual-thread locking screw can be found for optimisation. The DDP, including an L plate with 0°, 30° and 60° angles and a straight I plate, were made with Ti6Al4V to fix onto the sawbones with three corresponding radius fractures to perform the dynamic testing. The specimens were oscillated with loads between 10 N and 150 N at 5 Hz for 20,000 cycles. The average stiffness in 20,000 test cycles was 425.7 N/mm, 461.1 N/mm and 532.1N/mm for the 0°, 30° and 60° constructs, respectively. No difference in stiffness was found in the same angled constructs throughout the 20,000 cycles of testing (p > 0.05). Lack of gross construct failures during cyclic testing and reasonable stiffness corroborated that our new constructs tested to date seem stable enough to support restricted post-operative loads.

Visibility enhancement of common bile duct for laparoscopic cholecystectomy by vivid fiber-optic indication: a porcine experiment trial.

Bile duct injury (BDI) is the most serious iatrogenic complication during laparoscopic cholecystectomy (LC) and occurs easily in inexperienced surgeons since the position of common bile duct (CBD) and its related ductal junctions are hard to precisely identify in the hepatic anatomy during surgery. BDI can be devastating, leading to chronic morbidity, high mortality, and prolonged hospitalization. In addition, it is the most frequent injury resulting in litigation and the most likely injury associated with a successful medical malpractice claim against surgeons. This study introduces a novel method for conveniently and rapidly indicating the anatomical location of CBD during LC by the direct fiber-optic illumination of 532-nm diode-pumped solid state laser through a microstructured plastic optical fiber to avoid the wrong identification of CBD and the injury from mistakenly cutting the CBD that can lead to permanent and even life threatening consequences. Six porcine were used for preliminary intra-CBD illumination experiments via laparotomy and direct duodenal incision to insert the invented CBD illumination laser catheter with nonharmful but satisfactory visual optical density.

Determination of azimuthal anchoring strength in twisted nematic liquid crystal cells using heterodyne polarimeter.

Two external-field-free methods are presented for measuring the azimuthal anchoring strength in twisted nematic liquid crystal (TNLC) cells. For asymmetrical TNLC samples, the twist angle is derived from the phase of the detected signal in a phase-sensitive heterodyne polarimeter and is then used to calculate the weak anchoring strength directly. The measurement resolution which is found to be about 0.01 µJ/m(2) makes the present method sensitive enough for the LC-based bio-sensing application. Using the proposed method, the weak azimuthal anchoring strength of a composite liquid crystal mixture (40% LCT-061153 + 60% MJO-42761) in contact with a plasma-alignment layer is found to be 7.19 µJ/m(2). For symmetrical TNLC samples, the liquid crystals are injected into a wedge cell, and the two-dimensional distributions of the twist angle and cell gap are extracted from the detected phase distribution using a genetic algorithm (GA). The azimuthal anchoring strength is then obtained by applying a fitting technique to the twist angle vs. cell gap curve. Utilizing the proposed approach, it is shown that the strong anchoring strength between a rubbed polyimide (PI) alignment layer and E7 liquid crystal is around 160 µJ/m(2) while that between a rubbed PI alignment layer and MLC-7023 liquid crystal is approximately 32 µJ/m(2).

Measurement of linear birefringence and diattenuation properties of optical samples using polarimeter and Stokes parameters.

A technique is proposed for measuring the linear birefringence and linear diattenuation of an optical sample using a polarimeter. In the proposed approach, the principal axis angle (alpha), phase retardance (beta), diattenuation axis angle (thetad), and diattenuation (D) are derived using an analytical model based on the Mueller matrix formulation and the Stokes parameters. The dynamic measurement ranges of the four parameters are shown to be alpha = 0 approximately 180 degrees, beta = 0 approximately 180 degrees, theta(d) = 0 approximately 180 degrees, and D = 0 approximately 1, respectively. Thus, full-range measurements are possible for all parameters other than beta. In this study, the proposed methodology does not require the principal birefringence axes and diattenuation axes to be aligned. In addition, the linear birefringence and linear diattenuation properties are decoupled within the analytical model, and thus the birefringence properties of the sample can be solved directly without any prior knowledge of the diattenuation parameters. Also, the characteristic parameters in the baked polarizer with linear birefringence are successfully extracted from an optically equivalent model and proved by the respective simulation and experiment introduced in this study.

Full-field and full-range sequential measurement of the slow axis angle and phase retardation of linear birefringent materials.

A method is proposed for obtaining full-range sequential measurements of the slow axis angle and phase retardation of linear birefringent materials (LBMs) using a full-field heterodyne interferometer with a charge-coupled device (CCD) camera and an image processing algorithm based on a three-frame integrating-bucket method. The dynamic ranges of the principal axis and phase retardation measurements extend from 0 degrees to 180 degrees and from 0 degrees to 360 degrees , respectively. The proposed method not only enables full-range measurements of the slow axis angle to be obtained, but also allows a decision to be made as to whether the principal axis labeled by the manufacturer is the slow axis or the fast axis. The standard deviations of the slow axis angle and phase retardation measurements are found to be 0.14 degrees and 0.27 degrees, respectively. In addition, it is shown that the noises induced by environmental disturbances are reduced by elimination of the dc component of the output light intensity in the image processing algorithm. We also investigate the sensitivity of the measured error caused by the orientation of LBM.

Full-field heterodyne polariscope with an image signal processing method for principal axis and phase retardation measurements.

We develop a heterodyne polariscope for measuring the two-dimensional principal axis and phase retardation in a linear birefringence material using novel three-frame and two-frame integrating-bucket methods and a CCD. By using a complex programmable logic device to provide an external trigger to the CCD, integrating buckets with multiple frames are achieved. The advantages of the proposed three-frame and two-frame integrating-bucket methods include a simpler signal processing algorithm based on fewer frames and the elimination of flyback error caused by a sawtooth modulation signal at higher frequencies.