How servant leadership predicts employee resilience in public organizations: a social identity perspective.

Through the lens of social identity theory, this work aims to investigate the impact of servant leadership on employee resilience during the COVID-19 pandemic and to explore their underlying mechanisms through two types of social identity: organizational identification and professional identity. To test our hypotheses, an online survey was conducted via a large number of 703 employees working in public organizations in southwest China. Results yielded from the structural equation modeling analysis via AMOS (24.0) indicated that the effect of servant leadership on employee resilience was fully mediated by organizational identification and professional identity, respectively. Besides, the association between servant leadership and employee resilience was sequentially mediated from organizational identification to professional identity, and from professional identity to organizational identification. This study provides the first evidence of the predictive effect of servant leadership on employee resilience through organizational identification and professional identity, highlighting the significance of social identity for building and maintaining employees' resilience in coping with challenges posed by COVID-19.

The Relationship Between Perceived Residential Environment Quality (PREQ) and Community Identity: Flow and Social Capital as Mediators.

The wide-spread novel coronavirus disease (Covid-19) has posed severe challenges to people's life especially their life style. Due to the residential confinement contingency, people were restricted in their study, work and leisure within constrained residential community. The physical environment of residential community therefore became the main activity place and it thus played a significant role for facilitating inhabitants' daily activities and influencing community identity. Based on the eudaimonic identity theory, this study explored how the spatial dimensions of perceived residential environment quality (PREQ), activity experience (i.e., flow) and social capital, would impact on urbanities' residential community identity during Covid-19. Results from 508 Chinese residential inhabitants analyzed via structural equation modeling suggested that: a better degree in the spatial dimensions of PREQ would predict a stronger community identity; flow and social capital mediated the relationship between the spatial dimensions of PREQ and the inhabitants' community identity. The implications of such accounts for our understanding of community identity are then discussed, considering the important meaning of the relationships between people and the perceived physical properties of their residential place.

Expanding Social, Psychological, and Physical Indicators of Urbanites' Life Satisfaction toward Residential Community: A Structural Equation Modeling Analysis.

Attention on, and interest in, life satisfaction has increased worldwide. However, research on life satisfaction focused toward the urban dwellers' residential community is mainly from western countries, and the limited research from China is solely focused on the geriatric population via a narrowly constrained research perspective. This study, therefore, aimed to investigate urbanites' life satisfaction toward their community, combining the psychological (behavioral community engagement, mental state of flow, and cognitive community identity), physical (PREQIs-perceived residential environment quality indicators: e.g., green area), and social perspectives (social capital). The proposed conceptual model was tested on a regionally representative sample of 508 urban community residents in the city of Chengdu, Sichuan province, China. Data were analyzed via a structure equation modelling approach in AMOS software. Findings suggested that all of the psychological, physical and social factors contributed to a prediction of life satisfaction. Specifically, social capital mediated the path from community engagement and flow to life satisfaction, and community identity mediated the path from flow experience and green area to life satisfaction. Additionally, social capital contributed to predict life satisfaction through its influence on community identity. Findings provide suggestions for urban designers and policymakers to focus on creating an urban community equipped with green area, which helps to promote physical activities that are flow-productive, to enhance residents' identification to their residential community and, therefore, increase life satisfaction.

Identification of lncRNAs Associated with Prognosis of Rectal Cancer by Comprehensive Bioinformatics Analysis Based on TCGA.

BACKGROUND: Although many advances have been made in the field of molecular biology, new approaches are still required to reveal the molecular mechanisms underlying the pathogenesis of rectal cancer and identify specific diagnostic and therapeutic targets. METHODS: Here, we determined the expression profiles of lncRNA, mRNA, and microRNA (miRNA) in rectal cancer, and constructed the lncRNA-mRNA-miRNA ceRNA networks to identify the hub lncRNAs, mRNAs, and miRNAs involved in this cancer. Moreover, survival analysis was performed to identify survival-related genes. RESULTS: A total of 69 DElncRNAs, 32 DEmiRNAs, and 84 DEmRNAs were included in the ceRNA network. Based on the ceRNA principle, lncRNA ADAMTS9-AS2 was predicted to regulate the expression of FOXF2 gene through competitive binding to miR-182. The result of log-rank test showed that three lncRNAs, five mRNAs, and one miRNA were associated with survival of rectal adenocarcinoma patients and multivariate Cox regression analysis identified four lncRNA signatures as prognostic factors. CONCLUSIONS: These findings add to our understanding on the molecular mechanisms underlying the pathogenesis of rectal cancer and reveal potential diagnostic and therapeutic targets.

Network analysis based on TCGA reveals hub genes in colon cancer.

Colorectal cancer (CRC) is the third most widespread cancer in the world. Although many advances have been made in molecular biology, novel approaches are still required to reveal molecular mechanisms for the diagnosis and therapy of colon cancer. In this study, we aimed to determine and analyse the hub genes of CRC. First, we explored the mRNA and microRNA (miRNA) expression profiles of colon carcinoma, then we screened target genes of differentially expressed miRNAs and obtained the intersection between differently expressed genes and target genes. Gene Ontology (GO) classification and KEGG pathway analysis of differently expressed genes were performed, and gene-miRNA and TF-gene-miRNA networks were constructed to identify hub genes, miRNAs, and TFs. In total, 3436 significant differentially expressed genes (1709 upregulated and 1727 downregulated) and 216 differentially expressed miRNAs (99 upregulated and 117 downregulated) were identified in colon cancer. These differentially expressed genes were significantly enriched in GO terms and KEGG pathways, such as cell proliferation, cell adhesion, and cytokine-cytokine receptor interaction signalling pathways. GCNT4, EDN2, and so on were located in the central hub of the co-expression network. MYC, WT1, mir-34a, and LEF1 were located in the central hub of the network of TF-gene-miRNA. These findings increase our understanding of the molecular mechanisms of colon cancer and will aid in identifying potential targets for diagnostic and therapeutic usage.

Nontyphoidal Salmonella Gastroenteritis in Baoshan, Shanghai, China, 2010 to 2014: An Etiological Surveillance and Case-Control Study.

Nontyphoidal Salmonella (NTS) gastroenteritis is a widespread global foodborne disease. To identify the epidemiologic characteristics, sources of food contamination, and risk factors of NTS gastroenteritis, epidemiologic data and stool specimens of diarrheal patients were collected from sentinel hospitals in Baoshan, Shanghai, People's Republic of China, between 2010 and 2014. Food products from nearby farmers' markets and animal feces from live poultry markets and livestock farms were sampled to identify the pathogen; a case-control study was conducted to characterize risk factors of NTS gastroenteritis. Of 3,906 diarrheal patients examined, 266 (6.8%) were positive for Salmonella. The positive rates were higher in summer than in the other seasons. Salmonella Typhimurium (36.1%) and Salmonella Enteritidis (30.8%) were the dominant serovars in the patients. Salmonella was detected in 26.2% pork samples, 7.1 to 7.8% poultry meats, and 3.3 to 8.9% poultry feces. Salmonella Typhimurium was the major serovar in contaminated food and animal feces. Multivariate conditional logistic regression analysis indicated that consumption of pork and quickly cooked eggs increased, whereas separating kitchen knives for cooked and raw food decreased the risk of NTS gastroenteritis, independently. We believe that NTS in poultry feces contaminated the meat products in the same markets and then infected humans if these foods were not sufficiently cooked. To prevent NTS gastroenteritis, it is necessary to survey Salmonella in meats and poultry feces, to cook eggs and pork sufficiently, to separate kitchen knives for cooked and raw food, and to prohibit live poultry trade in fresh meat markets.

[Study on risk factors of sporadic hepatitis E virus cases in some districts of Shanghai].

OBJECTIVE: To study the risk factors of acute sporadic hepatitis E virus (HEV) cases and to analyze its partial sequence in some districts of Shanghai. METHODS: 30 blood samples were collected from the acute sporadic HEV cases in 2003-2004 and the RT-nPCR method was applied to obtain the sequence of HEV in these cases. Meanwhile, a 1:2 case-control study was used to identify risk factors in the process of sporadic HEV infection in these regions of Shanghai. RESULTS: Data from the sequential analysis showed that HEV of the sporadic cases belonged to HEV genotype IV. Finding from the case-control study implicated that the housing condition, outside eating history, especially seafoods (OR = 7.048) played an important role in the infection of HEV. Results from multiple logistic regression showed that eating raw seafoods appeared to be one of the risk factors of HEV infection. CONCLUSION: HEV sequences isolated from the sporadic cases of HEV in some districts of Shanghai belonged to HEV genotype IV. Foods, especially seafood, were the risk factors in the infection of HEV.