Bibliometric analysis of subject trends and knowledge structures of gut microbiota.

BACKGROUND: Gut microbiota is an emerging field of research, with related research having breakthrough development in the past 15 years. Bibliometric analysis can be applied to analyze the evolutionary trends and emerging hotspots in this field. AIM: To study the subject trends and knowledge structures of gut microbiota related research fields from 2004 to 2018. METHODS: The literature data on gut microbiota were identified and downloaded from the PubMed database. Through biclustering analysis, strategic diagrams, and social network analysis diagrams, the main trend and knowledge structure of research fields concerning gut microbiota were analyzed to obtain and compare the research hotspots in each period. RESULTS: According to the strategic coordinates and social relationship network map, Clostridium Infections/microbiology, Clostridium Infections/therapy, RNA, Ribosomal, 16S/genetics, Microbiota/genetics, Microbiota/immunology, Dysbiosis/immunology, Infla-mmation/immunology, Fecal Microbiota Transplantation/methods, Fecal Microbiota Transplantation can be used as an emerging research hotspot in the past 5 years (2014-2018). CONCLUSION: Some subjects were not yet fully studied according to the strategic coordinates; and the emerging hotspots in the social network map can be considered as directions of future research.

Change of heart function and its relationship with AMS during acute high-altitude exposure at 3658 m in Chongqing soldiers / 中国病理生理杂志

AIM: To observe the cardiac function during high-altitude exposure in Chongqing soldiers and to discuss its relationship with acute mountain sickness ( AMS ) by echocardiography .METHODS: The changes of heart function were evaluated during acute high-altitude exposure (3658 m, 3 d) in 42 healthy young male soldiers by echocar-diography.At the same time, the heart rate, blood pressure, blood oxygen saturation, and the incidence of AMS after high-altitude exposure were observed and recorded .RESULTS:Three days after arrival at 3658 m, the left atrial end-systolic dimension (LADs), left ventricular end-diastolic dimension (LVDd) and right atrial end-systolic dimension were signifi-cantly decreased , but the right ventricular outflow tract diameter , pulmonary artery dimension , ejection fraction , cardiac output (CO), pulmonary arterial systolic pressure (PASP) and mean pulmonary arterial pressure were significantly in-creased compared with the baseline levels in all subjects .The mitral peak E velocity was significantly reduced (P<0.05). A total of 42 healthy young men were recruited and divided into AMS group with 15 subjects and non-AMS group with 27 subjects by Lake Louise scoring after high-altitude exposure .The cardiac function in the plain showed that aortic sinus di-ameter and LVDd in AMS group were significantly smaller , and PASP was significantly higher than those in non-AMS group.After high-altitude exposure, the LADs in AMS group was significantly smaller than that in non-AMS group (P<0.05).AMS scores and CO in the plain showed significant negative correlation (r=-0.3814, P<0.05).CONCLU-SION:Upon acute high-altitude exposure , right ventricular functions of the young male soldiers are damaged with the com-pensation of the left ventricular functions .Using echocardiography to observe PASP and CO may be helpful for screening the susceptible people of AMS in the plain .