RESUMO
AIM: To develop a model of assessment of individual risk of dependence on synthetic cannabinoids based on genetic factors and diagnosis of attention deficit hyperactivity disorder (ADHD). MATERIAL AND METHODS: The study included 146 male adolescents using synthetic cannabinoids and 136 healthy people. The genetic study considered the combination of dependence on synthetic cannabinoids and ADHD. Six polymorphisms in the genes of dopaminergic and serotonergic systems were genotyped. RESULTS AND CONCLUSION: In general, the results of this work confirm the important role of the dopaminergic and serotonergic systems in the pathogenesis of substance use disorders, and the significance of changes in the nucleotide sequences of DRD2, SLC6A3, HTR2A genes in the development of dependence on synthetic cannabinoids with ADHD.
Assuntos
Transtorno do Deficit de Atenção com Hiperatividade , Canabinoides , Transtornos Relacionados ao Uso de Substâncias , Adolescente , Proteínas da Membrana Plasmática de Transporte de Dopamina , Genótipo , Humanos , Masculino , Polimorfismo GenéticoRESUMO
AIM: To assess the efficacy of monotherapy of anxiety in alcoholism with alimemazine (teraligen). MATERIAL AND METHODS: Thirty-six patients with alcohol addiction were treated with alimemazine in dose 15 mg during 9 month. In control group (11 patients) teraligen was no used. RESULTS AND CONCLUSION: A significant positive effect of treatment with teraligen was observed. There were the improvement in alcohol addiction course, decrease in scores on the Addiction Severity Index (ASI) from severe to mild level and decrease in trait and state anxiety measured with the Spielberger-Khanin scale from high to low levels. The reduction on symptoms of depression from moderate (at baseline) to subdepressive levels on the Beck Depression Inventory was noted in the end of treatment.