Selectivity of an Ag/BTO-Based Nanocomposite as a Gas Sensor Between NO2 and SO2 Gases.

The novel Ag/BTO/TiO2 nanocomposite was assessed for its gas-sensing capabilities toward hazardous gases NO2 and SO2. It exhibited p-type behavior with increasing resistance for SO2 with a response and recovery time of ∼5 and ∼2 s, respectively, switching to n-type behavior when exposed to NO2 with a response and recovery time of ∼20 and ∼250 s, respectively. Analyte gas concentrations from 0 to 220 ppm were taken for analysis. Selectivity analysis at room temperature revealed NO2's superior response of ∼20% above 180 ppm, compared to SO2's < 3% response at 180 ppm. NO2(VC) achieved its highest response (∼45%) at 30 ppm and remained constant above 80 ppm, while SO2(VC) peaked at ∼30% at 60 ppm but declined with increasing flow rates. Further, the increasing temperature led to an amplified response for NO2, whereas SO2 showed an increase in response after 180 °C. SO2(VC) exhibited a significant response of ∼70% from 140 °C onward. Additionally, NO2(VC) showed distinct peaks at 160, 250, and 290 °C with responses of 50, 65, and 80%, respectively. The calculated limit of detection values were 236 ppm for NO2, 644.07 ppm for SO2, 401.32 ppm for NO2(VC), and 496.86 ppm for SO2(VC).

Electrochemical biosensors in healthcare services: bibliometric analysis and recent developments.

Biosensors are nowadays being used in various fields including disease diagnosis and clinical analysis. The ability to detect biomolecules associated with disease is vital not only for accurate diagnosis of disease but also for drug discovery and development. Among the different types of biosensors, electrochemical biosensor is most widely used in clinical and health care services especially in multiplex assays due to its high susceptibility, low cost and small in size. This article includes comprehensive review of biosensors in medical field with special emphasis on electrochemical biosensors for multiplex assays and in healthcare services. Also, the publications on electrochemical biosensors are increasing rapidly; therefore, it is crucial to be aware of any latest developments or trends in this field of research. We used bibliometric analyses to summarize the progress of this research area. The study includes global publication counts on electrochemical biosensors for healthcare along with various bibliometric data analyses by VOSviewer software. The study also recognizes the top authors and journals in the related area, and determines proposal for monitoring research.

Methyltransferase as Antibiotics Against Foodborne Pathogens: An In Silico Approach for Exploring Enzyme as Enzymobiotics.

The development of resistance in microbes against antibiotics and limited choice for the use of chemical preservatives in food lead the urgent need to search for an alternative to antibiotics. The enzymes are catalytic proteins that catalyze digestion of bacterial cell walls and protein requirements for the survival of the cell. To study methyltransferase as antibiotics against foodborne pathogen, the methyltransferase enzyme sequence was modeled and its interactions were analyzed against a membrane protein of the gram-positive and gram-negative bacteria through in silico protein-protein interactions. The methyltransferase interaction with cellular protein was found to be maximum, due to the maximum PatchDock Score (15808), which was followed by colicin (12864) and amoxicillin (4122). The modeled protein has found to be interact more significantly to inhibit the indicator bacteria than the tested antibiotics and antimicrobial colicin protein. Thus, model enzyme methyltransferase could be used as enzymobiotics. Moreover, peptide sequences similar to this enzyme sequence need to be designed and evaluated against the microbial pathogen.